Oxytocin (Pitocin, Syntocinon)

Question 1

Classification

Answer 1

Synthetic Hormone

Question 2

Mechanism of Action

Answer 2

• Causes rythmic contractions of uterine smooth muscles
• Decreases bleeding from uterine vessels

Question 3

Indications

Answer 3

• Postpartum hemorrhage after expulsion of the placenta

Question 4

Contraindications

Answer 4

• Hypersensitivity

Question 5

Adverse Effects

Answer 5

• Hyper/hypotension, water retention, dysrythmias
• Seizures, coma, subarachnoid bleeding
• Uterine spasm, uterine rupture

Question 6

Administration

Answer 6

• IVPB: 10-20 U in 500-1000 cc of NSS, run at 1-2 cc/min, titrate to severity of bleeding & uterine response.
• IM: 3-10 Units

Question 7

Special Considerations

Answer 7

• Should be used in conjuction with fundal massage
• Evaluate the uterine fundus every 5 minutes before & during administration.
• After delivery of the neonate & placenta & before administration, make sure another fetus is not expected.