Oxytocin

Question 0

Mechanism of action

Answer 0

Binders to oxytocin receptors in uterine SMC,initiates activity of second messenger results in intercellular calcium which promotes contraction of uterine muscle.

Question 1

Trade name

Answer 1

Pitocin

Question 2

Pharmacokinetics

Answer 2

O immediate iv 3-7 I’m
P varies
D 1 hour iv 2-3 hours I’m
H 3-5 minuets

Question 3

Onset

Answer 3

Immediate iv

3-7 m I’m

Question 4

Peak effects

Answer 4

Varies

Question 5

Duration of effects

Answer 5

1 hour iv

2-3 hour I’m

Question 6

Half-life

Answer 6

3-5 m

Question 7

Indications/field use

Answer 7

Post-partum hemorrhage

Question 8

Contraindications

Answer 8

Baby and placenta not delivered

Additional fetus present

If given before delivery fetal hypoxia fetal asphyxia
Fetal intracranial bleeding

Question 9

Side effects

Answer 9

Hypotension tachycardia dysrhythmias seizures coma N+V

Question 10

Dose

Answer 10

3-30 units IM

10-20 units in 500 ml or 1000 ml D5W, bs, or LR SLOW IV IO INFUSION

Question 11

Precautions

Answer 11

Can cause over stimulation of uterus possible uterine rupture monitor uterine tone

Question 12

D to d

Answer 12

HTV WITH VASOCONSTRICTORS LIKE NE