Oxidative Phosphorylation Pathway Flashcards
What is the name of the complex, and what are its prosthetic groups?
II
Succinate-CoQ reductase; FAD and Fe-S
What is the name of the complex, and what are its prosthetic groups?
III
CoQH2-cytochrome c reductase; hemes and Fe-S
What is the name of the complex, and what are its prosthetic groups?
cytochrome c
cytochrome c; heme
What is the name of the complex, and what are its prosthetic groups?
IV
cytochrome c oxidase; Hemes and Cu’s
What does Complex I do?
- accepts 2 e- from NADH
- uses their E to pump 4 H+ from matrix to IMS
- passes e-s to Coenz. Q along w/ 2 H+
What does Complex II do?
- accepts 2 e- from succinate
- transfers e-s and 2 H+ to Coenz. Q
- NO H+ pumping activity
What does Coenzyme Q do?
- donates e- to Complex III
2. releases 2 H+ into IMS
What does Complex III do?
- accepts 2 e-s from CoQ
- uses their E to pump 2 H+ into IMS
- donates e- to cytochrome c
What does cytochrome c do?
- accepts e- from Complex III
- transports e- to Complex IV
- exists w/ aqueous IMS
What does Complex IV do?
- accepts 2 e-s from 2 cytochrome c’s
- uses their E to pump 2 H+ into IMS
- donates e- to oxygen
- produces water
How many protons are moved through the NADH path and through what complexes?
How many protons are moved through the FADHH path and through what complexes?
10; I, CoQ, III, and IV
6; CoQ, III, and IV
What is another name for Complex V? What are its subunits? What does each subunit do?
ATP Synthase; F1 and F0; F1 catalyzes ATP synthesis, F0 moves 3 H+ from IMS to matrix
Where do the 4 H+ come from that go into the matrix?
3 from Complex V
1 from H+/inorganic P symporter
What is the name of the complex, and what are its prosthetic groups?
I
NADH-CoQ reductase; FMN and Fe-S
