Oxidative Phosphorylation Flashcards
Stages of fuel oxidation
- Fuel
- release CO2 - Reduced coenzymes (NADH, FADH2)
- release H20 - ATP
Fuel oxidation provides energy for processes through generation of what?
Reduced coenzymes, NADH and FADH2
Anaerobic glycolysis (3)
- carbohydrates may be used to generate ATP through a non- oxidative pathway
- fast
- glucose –> lactate
Oxidative phosphorylation
-definiton
The process by which the oxidation of reduced nucleotide coenzymes is coupled to the synthesis of ATP
Oxidative phosphorylation is based on:
Chemiosmosis: energy for ATP synthesis is provided by an electrochemical gradient across the INNER MITOCHONDRIAL MEMBRANE
Electrochemical gradient is generated by components of the…
Electron transport chain, which pump protons across the inner mitochondrial membrane as they accept and donate electrons
In fuel metabolism
- what is oxidized
- what is reduced
- fuel donates electrons, it is oxidized
- NAD+ and FAD accept electrons, it is reduced
3 ways in which compounds can e oxidized in the body:
- the transfer of electrons from the compound as a hydrogen atom or a hydride ion
- the direct addition of oxygen from O2
- the direct donation of electrons (ex: Fe2+ –> Fe3+)
Reduction potential
- definition
- meaning of E’
- is a measure of the energy change when that compound accepts electrons, E’o (in volts)
- willingness of the compound to accept electrons
Reduction potential
-characteristics
-the more negative the reduction potential of a compound, the greater is the energy available for ATP generation
Oxidative phosphorylation
-generation of ATP requires: (5)
- an electron donor (NADH or FADH2)
- an electron acceptor (O2)
- ATP synthase
- an inner mitochondrial membrane impermeable to protons
- all components of the electron transport chain
Electron transport chain
-order of complexes (7)
- Complex I
- Complex 2
- Coenzyme Q
- Complex 3
- Cytochrome C
- Complex 4
- ATP synthase
Name of complex I, II, III, IV
I: NADH dehydrogenase
II: Succinate dehydrogenase
III: Cytochrome b-c 1 complex
IV: Cytochrome c oxidase
Complex I, III, IV
-definition
-multi- sub-unit protein complexes spanning the inner mitochondrial membrane
Name of the final electron acceptor in the electron transport chain
O2