Oxazolidinones

Question 1

MoA

Spectrum of Activity

Answer 1

-binds 50S ribosome, preventing the initiation comple –> inhibits protein synthesis initiation

-Resistant G+ organisms:
MSSA/MRSA/S. epidermidis
-Penicillin/cefotaxime resistant pneumococci
-Enterococci, including VRE

Question 2

Adverse effects

What is the number 1 reason for d/c linezolid?

Answer 2

N/D, h/a
Tongue, tooth discolouration
Taste perversion, thrush
Optic neuropathy (peripheral neuropathy with vision loss)**
Blood dyscrasias: Thrombocytopenia, leukopenia, PRCA
Lactic Acidosis

Due to THROMBOCYTOPENIA

Question 3

When is linezolid preferred over vanco in MRSA Necrotizing Pneumonia?

Answer 3

• MRSA vanco has high MIC
• Concurrent nephrotoxic agents
• Pre-existing renal dysfunction