Overview Summary Flashcards
Linear, Non-threshold
Diagnostic and leukemia are plotted on this curve
ACUTE RADIATION SYNDROME
Whole body irradiation. Three divisions. Accidental exposure
Hematologic Syndrome
Longest latency period.
1-10 Gy (100-1000 Rads)
Death due to infection from body’s own flora; prone to hemorrhage=bone marrow destruction
GI SYNDROME
10-50 Gy (1000-5000 Rads)
Death within three days due to damage to bowel and bone marrow
CNS SYNDROME
SHORTEST LATENCY PERIOD
Death within seconds to minutes
+50 Gy (+5000 Rads)
Excessive fluid in brain
INCREASED DOSE=
Decreased latency period (symptom free period)
PRODOMINAL PERIOD
Appears first
Long-Term somatic effects
Cancer
Leukemia
Cataracts
Somatic effects
Occurs in the exposed individual
LD 50/60
Dose of radiation that would kill 50% of an exposed population in sixty days. (Approx 300-400 Rad)
Organogenesis
First trimester is the most dangerous time of exposure due to this
Indirect effects
95% of time
5%
Direct effect
Occupational dose
5 Rem/50 mSv per year
.5 Rem/5 mSv per year
General population annual dose
17 year old student
.1 Rem/1 mSv per year
50 Rem/500 mSv per year
Skin, thyroid, and extremities yearly dose
Lens of eye
15Rems/150 mSv annually
Age in years x 1 Rem/mSv
Calculation of cumulative occupational dose limit
Most radiosensitive/least radioresistant
Lymphocytes
Most radioresitant/least radiosensitive
Adult nerve cell
Increased O2 in cell»increased radiosensitivity
O2 enhancement ration (OER)
Cells radiosensitivity is DIRECTLY proportional to its reproductive activity and is INVERSELY proportional to its degree of specialization; AKA “precursor, immature, stem, undifferentiated”
Laws of Bergonie and Tribondeau
Linear energy transfer (LET) is _____________ to relative biological effect
Directly proportional
THRESHOLD
A minimum amount must be received before a response is seen