Overview of Hypersensitivity Flashcards
described as defense mechanism by which the body rids itself of potentially harmful antigens
immune response
if antigen persists, the immune response can damage the _
host
defined as an exaggerated response to a typically harmless antigen that results in injury to the tissue, disease, or even death
hypersensitivity
Type I hypersensitivity reactions are also known as
anaphylactic hypersensitivity
exposure to an antigen induces production of specific immunoglobulin E (IgE) antibody, which binds to receptors on mast cells and basophils
type 1 (anaphylactic)
what specific immunoglobulin produced in type 1 hypersensitivity
IgE
type 1, produces IgE which binds to receptors on _ and _ that results in _
mast cells and basophils; degradation
type II hypersensitivity, also known as
antibody-mediated cytotoxic hypersensitivity
Immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies react with antigens on the surface of host cells.
type 2 (antibody-mediated cytotoxic)
type 2. _ and _ antibodies that reacts on the _ of host cells.
IgG and IgM; surface
This can lead to cell damage by complement-mediated lysis or other mechanisms, dysfunction of the cell by blocking the binding of a ligand to a surface receptor, or overstimulation of a cell’s function.
type 2 (antibody-mediated cytotoxic)
Type III hypersensitivity is also referred to as _
complex-mediated hypersensitivity
IgG or IgM antibodies react with soluble antigens to form small complexes that precipitate in the tissues and activate complement.
type 3 (complex-mediated)
type 3. _ or _ antibodies react with _ antigens to form small complexes that precipitate in the tissues and activate complement
IgG or IgM; soluble
type 3. Recruitment of _ to the site results in an inflammatory response that causes injury to the tissues.
neutrophils
