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PHARM II, QUIZ 2 > Overractive Bladder > Flashcards

Overractive Bladder Flashcards

1
Q

Anticholinergics MOA for OAB

A

First line for urge incontinence

MOA:
Relaxes bladder smooth muscle (detrusor)

Decrease urgency symptoms by increasing bladder capacity

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2
Q

Anticholinergics CI & Warnings

A

CI:
Narrow Angle Glaucoma
Urinary / Gastric Obstructive Disorders

Warnings:
Hepatic / renal impairment
Myasthenia Gravis

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3
Q

Anticholinergics Drug Interactions

A

Other cholinergics

P450 3A4 metabolism!

examples???!

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4
Q

Anticholinergics for OAB

A

Oxybutynin (Ditropan)

Trospium (Sanctura) not for patients >75 +ADRs

Tolterodine (Detrol) ** 3A4 or cirrhosis, reduce dose **

Fesoterodin (Toviaz)

Solifenacin (Vesicare) Selective Muscarinic Antagonist

Darifenacin (Enablex) Muscarinic M3 receptor

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5
Q

Anticholinergics ADRs

A

Dry eyes, Dry mouth
Tachycardia
Headache
Constipation

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6
Q

Alternative Tx for OAB

A

Beta 3 Agonist - Mirabegron

Relaxes detrusor muscles, increases bladder capacity

ADRs
Headache
Nausea
Dizziness
Hypertension
Tachycardia
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7
Q

OAB Tx Guidelines

A

1st Line: Behavioral Therapy

2nd Line: Anticholinergic or Beta 3 Agonist
Caution with narrow angle glaucoma, impaired gastric emptying or urinary retention

3rd Line: BoTox Detrusor Injections

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PHARM II, QUIZ 2 (3 decks)

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