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Sem 4 Mini 3 > Ovarian Tumors of Non-Epithelial Origin and other Disorders > Flashcards

Ovarian Tumors of Non-Epithelial Origin and other Disorders Flashcards

1
Q

Histiogenesis of Germ Cell tumors

A
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2
Q

Dysgerminoma

Age?

Male Equivalent?

A

Young women and girls

Male equivalent is seminoma

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3
Q

Pathogenesis of Dysgerminoma

A

c-kit upregulated (diagnostic and theraputic target)

Transcription factors oct3,4, and Nanog maintain pleuripotency

Good prognosis

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4
Q

Gross Appearance of Dysgerminoma

A
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5
Q

Dysgerminoma Histopathology

A
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6
Q

Yolk Sac Tumor

Age?

Prognosis?

A

Young women <30 years of age

Good prognosis with chemotherapy

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7
Q

Gross appearance of Yolk sac tumor

A

Multiple cysts, hemorrhages

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8
Q

Diagnostic feature of yolk sac tumor

A

Increase in serum level of AFP

RICH in AFP

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9
Q

Yolk Sac tumor histopathology

A
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10
Q

Choriocarcinoma is identical to what?

A

Placental tumor

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11
Q

Choriocarcinoma course/timeline

A

Primary tumor may regress, leaving only metastasis sites

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12
Q

Types of epithelium involved in Choriocarcinoma

A

Syncytiotrophoblast

Cytotrophoblast

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13
Q

Choriocarcinoma gross appearance

A

Small hemorrhagic nidus/focus

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14
Q

Types of Ovarian teratomas?

A

Mature (benign, cystic (dermoid cyst))

Immature Teratoma

Monodermal (specialized)

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15
Q

Mature Teratoma

A

all three germ ayers

commonest germ cell tumor

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16
Q

Immature Teratoma

A

potentially malignant

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17
Q

Monodermal Teratoma

A

Struma ovarii

ovarian carcinoid

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18
Q

Mature Cystic Teratoma

Age?

A

Any age, usually younger patients

In elderly women–> might see malignant transformation (squamous cell carcinoma)

19
Q

Mature Cystic Teratoma gross appearance

A

Mature tissues haphazardly arranged

Hair, teeth, and sebaceous glad

Mature NORMAL tissue, haphazardly arranged. Mostly, Hair, teeth and csebaceous glands. But cartilage and intestinal epithelium may also be seen.

20
Q

Immature Teratoma

Age?

A

Prepubertal adolescents and young women

21
Q

Complication of immature ovarian teratoma

A

Potentially malignant

22
Q

Derivation of immature teratoma

A

immature neural tissue

23
Q

Two types of monodermal (specialized) teratoma

A

Struma Ovarii

Ovarian Carcinoid

24
Q

Complication of Struma Ovarii

A

thyrotoxicosis

25
Q

Complication of ovarian carcinoid

A

carcinoid syndrome

26
Q

Types of Sex chord stromal tumors

A

Granulosa cell tumor

thecoma

fibroma

sertoli-leydig cell tumor

gonadoblastoma

27
Q

Granulosa cell tumor Gross

A

Solid, yellow, small cysts

28
Q

Granulosa cell tumor Histopathology

A
29
Q

Fibromas, thecomas, and fibrothecomas

Benign or Malignant?

A

BENIGN

30
Q

Thecoma Histology and Marker

A

Histo= theca cells

Marker= estrogen

31
Q

Thecoma estrogen excess complication?

A

Dysfunctional uterine bleeding
Endometrial hyperplasia and carcinoma

32
Q

Thecoma Gross appearance?

Thecoma histological appearance?

A

Gross: Pale fleshy cut surface, yellowish fatty areas
Histopathology: Spindle cells with abundant lipid

33
Q

Fibroma?

A

Histologically, MEIGS Syndrome may be seen with the benign ovarian tumor may be a fibroma, thecoma, cystadenoma, or granulosa cell tumor. Fibromas are also associated with Benign Nevus syndrome.

34
Q

Sertoli-Leydig cell tumor

malignant or benign?

A

malignant

35
Q

Sertoli Leydig cell tumors secrete what?

A

May secrete Androgens

(Virilization or defeminizing symptoms)

36
Q

Sertoli Leydig cell tumor

Gross?

Histo?

A
37
Q

Granulosa Cell tumor marker?

A

INHIBIN

38
Q

Gonadoblastoma characteristic feature?

A

Dysgenic streak ovaries

(Germ cell component may undergo malignant change to form Dysgerminoma AND Granulosa cells)

39
Q

Primary sites for metastatic tumors?

A

Primary sites: breast > colon > endometrium > stomach

40
Q

Metastatic tumor characteristics?

A

B/L, solid

Histologically- adenocarcinoma

41
Q

What is a Krukenberg tumor?

A

Bilateral metastases of mucin-producing signet-ring cell carcinoma within the ovarian stroma

Bilateral fleshy cerebriform masses

42
Q

Krukenberg Tumor histo?

A

Clusters of Signet Ring Cells

43
Q

Where does Krukenberg tumor originiate from (What metastasizes)?

A

Metastasis from Gastric carcinoma

44
Q

Pathological Basis of signs and symptoms in the reproductive age female?

A

Sem 4 Mini 3 (7 decks)

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