Others Long Flashcards

1
Q

DDx for PUO

A
  • Infection: TB, abscess, endocariditis, pericarditis, OM, cholangitis, pyelonephritis
  • Cancer - Solid, lypmhoma, leukemia
  • CTDs - RA, SLE, rheumatic fever, stills
  • Vasculitis
  • Drug fever
  • IBD
  • Sarcoid/granulomatous disease
  • Thyroiditis
  • Hemolysis
  • Haematoma
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2
Q

Obesity Hx General questions

A
  • Timing of weight gain
  • FHx of obesity
  • MEds that may have contributed
  • Exercise, how often, type, how long
  • Eating patterns
  • Insight into the problem and willingness to address it
  • PRevious attempts to lose weight
  • Mood
  • Diabetes during pregnancy
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3
Q

Obesity Hx Complications

A
  • Arthritis
  • Diabetes
  • CVS risk and risk factors
  • Sleep apnea
  • Fatty liver
  • Mobility issues: balance, bathing
  • Social life and work
  • Mood
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4
Q

Waist circumference

A

> 88 cm for women
105 cm in men

associated with increased risk of diabetes, lipids, HTN, heart disease, independent of BMI

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5
Q

CRC Cancer screening

A
  • FOBT >50YO - every 2 years until age 75YO

- If mod-high risk - straight to sigmoidoscopy/C’scope

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6
Q

Breast Cancer screening

A
  • For asymptomatic/low risk women, mammograms every 2 years from age 50 to 74YO
  • If family history of breast cancer, mammograms every 2 years from age 40YO to 74YO
  • More specifically, if 1st-degree relative <50YO with breast cancer, annual mammograms from 40YO to 74YO.
  • If deemed high risk - refer to Oncologist for genetic screening/BRCA. Regular self-breast exams, annual mammograms/MRI/USS. Consider prophylaxis mastectomy/oophorectomy

If wanting mammogram >40YO - 50YOF, can have it, just not invited.

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7
Q

Cervical Cancer screening

A
  • ‘HPV test’ every 5 years from age 25 to 74YO (newish guideline)
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8
Q

HIV related conditions with severe immunosuppression

A
PJP
Kaposis
Non Hodgkins
Disseminated MAC
CMV
Cerebral toxoplasmosis
Oeseophageal candidiasis
AIDS dementia complex
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9
Q

Ix for all HIV patients

A
CD4 count
Viral load
Hepatitis serology A, B, C
CMV IgG
Syphillis serology
Toxoplasma antibodies
LFTs and UEC
CXR
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10
Q

Extra Ix in HIV if CD4 <200

A

Hepatitis C RNA
Cryptococcal antigen
Stool OCP

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11
Q

Extra Ix in HIV if CD4 <100

A

CMV PCR
Mycobacterial blood cultures
Fundoscopy
ECG

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12
Q

CD4 count 200-500 presentations

A
HSV
Oral candidiasis
Hairy leukoplakia
Kaposi's sarcoma
Pulmonary TB
Lymphoid interstiial pneumonitis
HIV associated indiopathic thrombocytopenia
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13
Q

CD4 count <200

A
PJP
Microsporidium and Cryptosporidium
Esophageal candidiasis
PN
Wasting
Miliary and extrapulmonary TB
HSV
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14
Q

CD4 Count <100

A
Cryptococcal meningitis
Cerebral toxo
CNS lymphoma
Dementia
Non hodkins
Multifocal leukoencephalopathy
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15
Q

NRTIs (Names)

A

nucleoside reverse transcriptase inhibitors (NRTIs)

Tenofovir 
-disoproxil fumarate(TDF)
-alafenamide(TAF)
Abacavir (ABC)
Zidovudine (ZDV/AZT)
Emtricitabine (FTC)
Lamivudine (3TC)
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16
Q

NNRTIs (Names)

A

non-nucleoside reverse transcriptase inhibitor

Efavirenz (EFV)
Nevirapine (NVP)
Rilpivirine
Etravirine

17
Q

PIs (Names)

A

Protease Inhibitors (PIs): “Navirs”

Atazanavir (ATV)
Darunavir
Lopinavir (LPV)
Ritonavir (RTV)

18
Q

ISTIs (Names)

A

Integrase Strand Transfer Inhibitors (ISTIs): “Gravirs”

Raltegravir
Elvitegravir
Dolutegravir
*Bictegravir- licenced 2018

19
Q

TDF Side effects

A

Renal failure: Characterised by raised creatinine, proteinuria, glycosuria, hypophosphatemia, and acute tubular necrosis – FANCONI syndrome – proximal renal tubular acidosis. Caution if eGFR <60
Bone loss - decreased bone mineral density - usually stabilizes with continued use

TAF – less toxicity than TDF

20
Q

Abacavir SEs

A

Hypersensitivity reaction

May worsen CAD

21
Q

Lamivudine SE

A

Pancreatitis

22
Q

Emtricitabine SE

A

skin discolouration usually as hyperpigmentation on palms and/or soles

23
Q

Efavirenz SE

A

Potent inducer of hepatic cytochrome P450
CNS toxicity, psychiatric – vivid dreams, confusion, dizziness
QTc prolongation
Elevated hepatic transaminases

24
Q

PI SEs

A

Nausea, diarrhoea!

Insulin resistance, hyperglycemia, diabetes, hyperlipidemia, lipodystrophy, hepatotoxicity

Interactions: Rifampicin!

25
Q

Alkylating agents

Chlorambucil,
Cyclophosphamide
Melphalan
Temozolomide

A

Pulmonary Fibrosis – Chlorambucil, Busulfan
Haemorrhagic cystitis – Ifosfamide, Cyclophosphamide
Bone marrow suppression, gonadal (cumulative effect), nausea – all agents

26
Q

Platinum agents:
Cisplatin
Carboplatin
Oxaplatin

A

Renal
Neuropathy
Ototoxicity
Nausea

27
Q

Antimetabolites:
MTX
Mercaptopurine
5-FU, Capecitabine, Cytarabine

A

Bone marrow suppression
Mucositis
GIT

28
Q

Anthracyclines:

Doxorubicin, Idarubicin

A

Cumulative cardiotoxicity
Mucositis
Alopecia
Bone marrow suppression

29
Q

Taxanes
Paclitaxel
Docetaxel

A

Neuropathy
Anaphylaxis
Myalgias

30
Q

Vinca Alkaloids

Vincristine

A

Neuropathy
Ileus
Bone marrow suppression

31
Q

Topoisomerase inhibitors

Etoposide

A
Bone marrow suppression
N+V
Alopecia
Regarding other CNS side effects:
Neurotoxicity + PN
32
Q

Depression Sx

A
S: sleep
A: appetite
D: dysphoria and anhedonia
F: fatigue
A: agitation/retardation
C: concentration
E: esteem
S: suicide
33
Q

Ix for urinary incontinence

A
  1. Rule out infection/ poorly controlled diabetes
    1. Check for haematuria - concern for malignancy
    2. Post void residual on USS + other anatomical issues
    3. Urodynamics may be required
      If concerns about neurological pathology: MRI Brain/Spine, referral to neurologist
34
Q

Acamprosate

A

(PBS): GABA agonist. Contraindicated in severe renal impairment. Can use in cirrhosis (Child’s Pugh A/B only). SE: Diarrhoea

35
Q

Naltrexone

A

Naltrexone (PBS): Opiate antagonist. Contraindicated: Opioid dependence, acute hepatitis, liver failure

36
Q

Dilsulfiram

A

Dilsulfiram (Not PBS - expensive): Alcohol deterrent. Interferes with alcohol breakdown and results in severe headaches, palpitations and vomiting due to acetaldehyde build up