Other Random Psych Flashcards
Lifetime prevalence of MDD in men? Women?
12% in men
20% in women
What is the RR of MDD in first degree relatives of probands?
2-3
41%:13% (monozygotic:dizygotic) condordance
SIG E CAPS?
Sleep, Interest, Guilt
Energy
Concentration, Appetite, Psychomotor, Suicide
Is bereavement an exclusion for MDD?
No because 2-month rule didn’t reflect reality, responds to same tx, same natural course
MDD + 2 or more of the following: keyed-up/tense, unusually restless, can’t concentrate b/c of worry, fear something awful will happen, might lose control
MDD with anxious distress
MDD + 3 or more manic/hypomanic sxs (minus distractibility)
MDD with mixed features
MDD + absolute anhedonia OR mood non-reactivity + 3 or more of the following: distinct quality of mood, worse in AM, early AM awakening, marked PMA or PMR, significant appetite or wt loss, excessive guilt
MDD with melancholic features
MDD + mood reactivity + 2 or more of the following: significant appetie or wt increase, hypersomnia, leaden paralysis, long-standing interpersonal rejection sensitivity leading to social/work problems
MDD with atypical features
What med works well for MDD with atypical features? What is first line?
SSRIs 1st line
MAOIs work well
MDD + delusions and/or hallucinations (congruent: personal inadequacy, guilt, death, nihilism, deserved punishment)
MDD with psychotic features (congruent or incongruent)
MDD + during MOST of the episode, 3 or more of the following: stupor, catalepsy, waxy flex, mutism, stereotypy, grimacing, echolalia, mannerisms, negativism
MDD with catatonia
MDD during pregnancy or in the 4 weeks after delivery
MDD with peripartum onset
MDD with relapses/remissions at characteristics times year (at least 2 MDE in last 2 yrs with no non-seasonal MDE)
MDD with seasonal pattern
If patients always gets depressed with seasonal unemployment (or beginning of school year), is that MDD with seasonal pattern?
NO!
Do antidepressants have additional actions besides inhibition of reuptake transporters?
Ys, increase neurogenesis in hippoccampus
What is the response rate to SSRIs in MDD?
47%
What is the remission rate with SSRIs in MDD?
33%