Other heart disease Flashcards
rheumatic heart disease
-systemic immune process that is a sequelae of Group A Beta Hemolytic Streptococcal infection of pharynx
-autoimmune type of reaction that is complication of strep -> NOT AN INFECTION OF VALVE
-Perivascular granulomatous reaction with vasculitis*
-75-80% Mitral valve, 30% Aortic valve, Tricuspid, and Pulmonic 5%.
-2-3 weeks post infection typical
-Become quite uncommon in US, seen in immigrant population
-Peak incidence 5- 15 yo
-Jones Criteria!*
jones criteria
-Must meet either:
-2 major criteria (2M)
-1 major and 2 minor (1M & 2m)
-Subclinical on echocardiogram
-Lower threshold in high-risk populations
MAJOR
-carditis
-erythema marginatum
-chorea
-subcutaneous nodules
-polyarthritis only (monoarthritis or polyarthritis- high risk)
MINOR
-polyarthralgia (monoarthralgia high risk)
-fever
-ESR >60 (30 for high risk) and/or CRP >3
-prolonged PR interval (first degree AV block)
Chronic RHD
-has rigidity and deformity of the valve cusps, fusion of the commissures or shortening and fusion of the chordae tendinea
-subsequent scarring after
-Valvular stenosis or regurgitation results.
-60% of pts with RHD report a history of RHD
rheumatic heart disease tx
-Bedrest until afebrile, normal SED rate, normal heart rate and EKG at baseline.
-Salicylates
-Fever reduction
-Joint pain reduction
-Penicillin
-Benzathine PCN once or Procaine PCN daily for 7 days
-Corticosteroids
-Prednisone daily taper over two weeks
-Joint symptom relief
rheumatic heart disease: prevention/prognosis
-Early treatment of strep throat with PCN.
-Prevent reoccurrence (50%)
-Initial episode can last weeks to months
-Mortality 1-2%
-30% of children affected die within 10 years
-After 10 years, 2/3 will have detectable valvular abnormalities
bacterial endocarditis
-Bacterial or fungal infection of the valvular or endocardial surface of heart
-Bacteria in the blood stream colonize a valve surface
-vegetations (pus, growing clumps of bacteria)
-Clinical presentation depends on organism and valve infected
-Staph Aureus more rapidly progressive and destructive infection -> drugs, IVs -> Leading cause
-Virulent organisms give an acute febrile illness complicated by early embolization
-Subacute picture with viridans strains or strep and enterococci, yeast and fungi
-Underlying valvular disease alters blood flow producing a jet, this disrupts endothelial surface… nidus for attachment!
-> Rheumatic valves, bicuspid aortic valve, sclerotic valves, hypertrophic subaortic stenosis, mitral valve prolapse (with regurgitation), congenital disorders. (Regurgitation valves more likely then stenotic) -> MONITOR
-bacteria can attach to these valves easily -> sepsis
endocarditis organisms
-Acute endocarditis: -> septic type sx
-Streptococcus pneumoniae
-Streptococcus pyogenes
-Neisseria gonorrhea
-Staphylococcus aureus- IV drug usersand large vegetations seen on valves
-Subacute bacterial endocarditisis characterized by slower onset and less severe symptoms:
-Streptococcus bovis (with a GI bacterai)- in the setting ofcolon cancer
-Enterococcus- in the setting ofgastrointestinal/genitourinary procedures
-Streptococcus viridans- often a complication ofdental procedures -> makes dextrans, which binds to fibrin-platelet aggregates on the heart valves
-Staphylococcus epidermidis- often in the setting ofprosthetic valves
-Candida albicans- IV drug users
-non-infectious endocarditis:
-Libman-Sacks endocarditis- (granulomatis) from systemic lupus erythematosus -> mitral or aortic valve involvement
-marantic endocarditis- from metastatic cancer seeding to the valves -> very poor prognosis
bacterial endocarditis: S&S
-Febrile
-Murmur
-Embolization (stroke, systemic, kidney)
-Metastatic infections
-Cough
-Dyspnea
-Arthralgias
-Arthritis
-Diarrhea
-Abdominal or Flank Pain (emboli to kidney)
-Peripheral lesions:
-Petechiae
-Subungual hemorrhages - splinter hemorrhages
-Osler nodes
-Janeway lesions
-Roth Spots- red in eyes
-conjunctival petechiae
duke criteria
-def dx with 2 major, 1 major, with 3 minor , or 5 minor
-possible dx with 1 major with 1 minor or 3 minor
MAJOR
-2 separate blood cultures at diff sites +
-echo evidence- vegetation, abscess
-new valve regurgitation- auscultate
MINOR
-heart condition or IV drug use
-temperature >38c
-vascular- emboli, septic pulmonary infarct, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, janeway
-immune process- glomerulonephritis, osler, roth, rheumatoid factor
-microbiological evidence- +blood culture (only 1), serologic evidence of active infection with organisms consistent with infective endocarditis
endocarditis work up
-Most common order:
-Mitral
-Aortic
-Tricuspid
-Pulmonic
-Imaging
-Transesophageal echocardiogram
-Labs
-Blood Cultures:
-3 sets at least 1 hour apart before starting antibiotics
endocarditis: complications
-perivalvular abscess
-Arrhythmias
-aneurysms
-heart failure
-Myocardial infarction
-Stroke
-Embolism to spleen or kidneys
-Septic pulmonary embolism/ lung abscesses
endocarditis work up: prevention
AHA recommends antibiotic prophylaxis with predisposing congenital or valvular anomalies having dental procedures, respiratory operations, operations of infected skin or musculoskeletal tissue
endocarditis tx
-Management approach:
-choice of antibiotics ultimatelydepend on causative agent and susceptibilityas well as the presence of prosthetic material in the heart
-all antibiotics should be given IV
-dual broad spectrum
-Medical:
-Treat infectious cause.
-IV antibiotics, anti-fungal, anticoagulation
-for pts with no prosthetic valve
-empiric antibiotic therapy
-operative:
-surgical valve replacement
indications*
-anyone with prosthetic valve
-heart failure
-patients who are refractory to medical therapy
-abscess formation
-conduction disturbance
myocarditis
-Primary: acute viral infection or post viral immune response (including COVID)
-Secondary: non-viral, medications, chemicals, inflammatory diseases, radiation, cocaine, chemotherapy (HER 2 positive Breast CA regime 28%)
myocarditis: S&S
-Heart failure
-Shock
-Pericardial friction rub
-Dyspnea
-Chest pain
-Tachycardia
-Gallop
-ST changes on EKG- broad inflammation changes
