Other Drugs For Asthma

Question 1

What are the INTERLUKIN INHIBITORS- used for asthma

Answer 1

Montelukast
Monoclonal antibodies.(BMDO)(BiMDO) - end in “umab”
- dupilumab
-mepolizumab
- omalizumab
Benralizumab

Question 2

What are the MOA and indication for MONO clinal antibodies

Answer 2

Generally bind to interlukin receptors reducing production of Estonphils reducing airway inflammation
Indicated last line for refractory esinophililic asthma as a add on therapy to optimised standard therapy

Question 3

What is montelukast and its MOA, Indication

Answer 3

INdication Montelukast used in maintenance treatment in asthma and exercise induced Asthma
> used on top of SABA+ ICS for asthma management
> used for seasonal allergic rhinitis but not superior over intranasal corticosteroids
MOA- inhibits interleukin reduced inflammation and smooth muscle contraction caused by interleukin

Question 4

What are the adverse effects and dosage for MOntelukast

Answer 4

COmmon a/e- headache , abdominal pain and diarrhoea
Rare- Neuropsychiatric effects - can cause nightmares ,hallucinations, mood or behavioural changes(anxiety, depression, aggression and suicide ideation)

Dosage- 4-5-10 OD
Adult- 10mg once daily
Kids 6+ 5mg ONCE daily
Kids<6yrs-4mg Daily

Question 5

What are the practice points and counselling for MOntelukast

Answer 5

Take it in the evening
Chewable tablets - chew thoroughly before swallowing don’t swallow it whole.