Other disorders linked to dopaminergic pathways

Question 1

How is Huntington’s linked?

Answer 1

Uncontrolled movements due to loss of striatal neurons. Lack of inhibition of dopamine neurons.

Question 2

How can we control Huntington’s?

Answer 2

D2 antagonists - tetrabenzine. However it is very difficult to reduce dyskinesia without causing akinesia.

Question 3

Is tourettes and ticking to do with dopamine?

Answer 3

Unknown origins but respond to dopamine antagonists.

Question 4

Is depression linked to dopamine?

Answer 4

Some evidence suggests role of diminished dopaminergic neurotransmission in major depression.

Could be diminished dopamine release or impaired signal transduction.