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36 Calcium and bone > Other bone protecting drugs > Flashcards

Other bone protecting drugs Flashcards

1
Q

What drugs may protect bones (apart from supplements and bisphosphonates)? (6 drugs)

A 
Raloxifene (SERM)
Calcitonin
Denosumab
Teriparatide
Strontium ranelate
Sodium fluoride
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2
Q

SERM used for bone protection (1 drug)

A

Raloxifene

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3
Q

Raloxifene - MOA

A

Activates estrogen receptors in bone while having antiestrogen effects in breast and uterine tissues

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4
Q

Raloxifene - adverse effects

A

Intensify postmenopausal symptoms
DVT
Stroke, pulmonary embolism

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5
Q

Raloxifene - indications

A

Postmenopausal osteoporosis

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6
Q

Calcitonin - indications

A

Osteoporosis if other drugs are not tolerated
Paget disease of the bone
Hypercalcemia

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7
Q

Denosumab - MOA

A

Inactivation of osteoclastic gene transcription by inhibition of RANKL (transmembrane protein).

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8
Q

Denosumab - indications

A

Osteoporosis

Prevention of skeletal events in cancers

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9
Q

Denosumab - adverse effects

A

Musculoskeletal pain
Hypercholesterolemia
Cystitis
Hypocalcemia

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10
Q

Which drug has opposite effects on bone with short-term and long-term treatment. (and which effects?)

A

Teriparatide
Short-term: Increase bone formation.
Long-term: stimulate bone resorption

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11
Q

Teriparatide - contraindications

A

Rapid cessation of the drug.

Risk of osteosarcoma (Paget disease of the bone)

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12
Q

Which drug increases the risk of osteosarcoma?

A

Teriparatide

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13
Q

Calcium and vit D supplements are important in treatment with which drugs? (2 drugs)

A

Calcitonin

Denosumab

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14
Q

Strontium ranelate - MOA

A

Decreases osteoclastic activity and bone resorption in newly formed bone. Induces proliferation of osteoblasts

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15
Q

Strontium ranelate - Indications

A

Prevention of osteoporosis

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16
Q

Sodium fluoride - MOA

A

Stored in bone and teeth. Replaces the hydroxyl group in calcium phosphate salts and form fluorapatite (more resistant to erosion)

17
Q

Why is sodium fluoride only used for dental health?

A

Excessive hardening of the bone (osteosclerosis), formation of demineralized bone

36 Calcium and bone (3 decks)

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