Other beta-lactams Flashcards
1
Q
Name examples of other β-lactam antibiotics
A
Penams (sulbactam and clavulanic acid)
Monobactams (Aztreonam and tigemonam)
2
Q
What organism produces clavulanic acid?
A
Streptomyces clavuligerus
3
Q
Clavulanic acid is the first clinically useful inhibitor. True or false?
A
True
4
Q
How does clavulanic acid inhibit β-lactamase?
A
It binds irreversibly to β-lactamase and is termed the “suicide inhibitor.”
5
Q
Clavulanic acid is an oxapenam. True or false?
A
True
6
Q
What are the characteristics of monobactams?
A
They are monocyclic with an N-sulphonic acid in the β-lactam ring.
7
Q
What is aztreonam synthesised from?
A
3-aminomonobactamic acid
8
Q
Describe the activity of aztreonam.
A
Selective activity against Gram-negative and most β-lactamase bacteria.
*Similar activity to aminoglycosides
