Other Anxiolytic Agents Flashcards
Which SSRIs are used to treat long-term anxiety?
Escitalopram.
Paroxetine.
Which SNRIs are used to treat long-term anxiety?
Venlafaxine.
Duloxetine.
Which medications should be considered a first-line treatment for patients with risk of addiction or dependence?
Selective serotonin reuptake inhibitors.
Selective serotonin and norepinephrine reuptake inhibitors.
What is the mechanism of action of buspirone?
Activation of serotonin 5-HT1A receptor with some affinity to dopamine DA2 receptor.
What is buspirone mainly used for?
Used for chronic treatment of generalized anxiety disorder.
How effective is buspirone compared to benzodiazepines for treating anxiety?
Similar efficacy, but with a different mechanism of action.
Why is buspirone not recommended for short-term or “as-needed” treatment of acute anxiety episodes?
It has a slow onset of action.
What are the advantages of buspirone use over benzodiazepines?
Sedation, psychomotor, and cognitive dysfunction are minimal.
Dependence is unlikely.
Minimal tolerance.
Doesn’t enhance alcohol’s sedative effects.
What are the disadvantages of buspirone use over benzodiazepines?
Slow onset of action (incompatible for acute anxiety).
No anticonvulsant or muscle-relaxant properties.
