Other anti-inflammatory drugs

Question 1

Montelukast indications

Answer 1

asthma (second line agent)

Question 2

US box warning montelukast (singulair)

Answer 2

serious NEUROPSYCHIATRIC EVENTS
- highly variable = agitation, aggression, depression, SI

• lukast think LOKO –> crazy –> neuropsychiatric effects

Question 3

MOA of montelukast

Answer 3

selective leukotriene receptor antagonist- inhibits receptors known with the pathophysiology of asthma

Question 4

Zafirlukast indications

Answer 4

asthma

Question 5

MOA of zafirlukast

Answer 5

selective leukotriene receptor antagonist- inhibits receptors known with the pathophysiology of asthma

Question 6

contraindications of zafirlukast

Answer 6

hepatic impairment

Question 7

Zileuton indications

Answer 7

asthma

Question 8

Contraindications of zileuton

Answer 8

active liver dz or liver enzymes > 3 time ULN

Question 9

ADR of zileuton

Answer 9

HA- 25% INCIDENCE

Question 10

Roflumilast indications

Answer 10

COPD (unique!)

Question 11

MOA of Roflumilast

Answer 11

phosphodiesterase-4 enzyme inhibitor (PDE-4 inhibitor) –> leads to accumulation of cyclic amp (cAMP)= suppresses cytokine release and inhibits lung infiltration by PMN and other leukocytes

Question 12

roflumilast contraindications

Answer 12

moderate to severe liver impairment

Question 13

omalizumab indications

Answer 13

asthma

Question 14

US box warnings - omalizumab

Answer 14

anaphylaxis- monitor closely

Question 15

MOA of omalizumab

Answer 15

igG monoclonal Ab that inhibits igE binding to igE receptor on most mast cells and basophils
= decreased igE binding reduces release of mediators in the allergic response

Question 16

ADR of omalizumab

Answer 16

1) injection site rxn –> subq injection