Other Flashcards
What is gold standard treatment for GBM?
Surgical resection + adjuvant RTx and temozolomide (alkylating agent)
When is BRCA testing indicated in ovarian cancer?
All individuals with high grade ovarian cancer
What is the mainstay of treatment for epithelial ovarian cancer?
Surgery - TAH-BSO and debulking
Adjuvant chemotherapy - platinum & taxane (unless early stage)
What is the most common kind of ovarian cancer?
Surface epithelial cancer
When are PARP inhibitors indicated in ovarian cancer?
For patient carrying BRCA1/2 mutation
What is the most common subtype of endometrial cancer?
- Endometrioid
- Serous
- Clear cell
Answer: endometrioid
What is the most common cancer after bowel cancer in Lynch syndrome?
Endometrial ca
Why is Ca125 not useful for screening women for ovarian cancer?
Elevated in <50% of women with early disease
Not specific - elevated in many other conditions (other ca, gynae conditions, menstruation)
What is usual chemo regime used for both ovarian and endometrial ca?
Carboplatin and paclitaxel
What is the most common form of RCC?
Clear cell RCC
What is the common genetic mutation found in 80% of clear cell RCCs?
Deletion on chromosome 3p > inactivation of VHL gene (TSG)
What is the common genetic mutation found in 80% of clear cell RCCs?
Deletion on chromosome 3p > inactivation of VHL gene (TSG)
Which class of chemotherapeutic agents is most likely to cause infertility?
Alkylating agents, mostly cyclophosphamide
Which class of chemotherapeutics is most likely to cause tissue damage if it extravasates?
Anthracyclines e.g. doxorubicine
Which chemotherapeutic agent classically causes cold dysaesthesias?
Oxaliplatin, used for CRC
