osteoporosis drugs Flashcards
what is raloxifene?
selective oestrogen receptor modulator (SERM)
what is alendronate?
bisphosphonate
what is the first-line drug class for osteoporosis?
bisphosphonates
which drug causes increased breast cancer and CVS events?
hormonal (oestrogen) replacement therapy
how and how often should bisphosphonates be administered?
orally 1/week or 1/month
which drugs cause osteonecrosis of jaw and atypical fractures
bisphosphonates (alendronate)
monoclonal antibody (denosumab)
which drug should be taken on an empty stomach?
bisphosphonates (alendronate)
which osteoporotic drug causes oesophageal and gastric irritation?
bisphosphonates
which osteoporotic drug causes increased risk of hypocalcaemia and flu-like symptoms
zoledronate (new bisphosphonate)
what is the mechanism of action of denosumab?
inhibits RANKL –> reduce number and function of osteoclasts
how is monoclonal antibody administerd?
s.c. 6 monthly
which drug could cause osteosarcoma and should be restricted to 18 months?
teriparatide (human PTH)
which order of drugs will avoid bone loss?
a) Teriparatide → denosumab
b) Denosumab → teriparatide
a) Teriparatide → denosumab
