Osteoporosis Flashcards
Osteoporosis: chronic or acute?
CHRONIC, PROGRESSIVE DISEASE
Osteoporosis characteristics
- low bone mass
- impaired bone quality
- decreased bone strength
- enhanced risk of fractures
Osteomalasia
soft bone
osteopenia
low bone mass
What does osteoporosis translate to?
“porous bone”
Incidence of osteoporotic fracture increases with?
AGE
Osteoporosis and women
- more common
- estrogen deficient women
- postmenopausal women have higher risk
Osteoporosis and men
- less common
- under diagnosed
- under treated
- underreported
- higher morbidity and mortality than women
- major public health problem
What is bone composed of?
- mostly collagen
- collagen = protein
- calcium phosphate
Two types of bone
- Compact cortical bone – outer shell, shaft, 80%
2. Cancellous/ spongy– inner parts of bone, 20%
Bone remodeling
resorption and formation of bone
occurs from the interaction of:
- osteocytes
- osteoclasts
- osteroblasts
Osteoclasts
cells that break down bone
life span of about 3 weeks
Osteoblasts
cells that form new bone
life span of about 3 months
Osteocytes
cells buried in bone, comprise 95% of bone cells
sense mechanical strain by sending signals to osteoblasts to increase bone formation or osteoclast to remove existing bone
Normal bone remodeling
Activation of osteoclasts Bone breakdown by osteoclasts Transition phase Bone formation by osteoblasts New bone matches amount broken down, hardens via MINERALIZATION PROCESS
How does osteoporosis occur?
mismatch between osteoclast and osteoblast activity
commonly a result of:
- aging
- change in hormones post menopause
- diets low in calcium and vitamin D