Osteoporosis

Question 1

What is bone remodeling

Answer 1

Requires a balance between bone formation by osteoblasts and bone resorption by osteoclasts

Question 2

what is osteoporosis

Answer 2

condition characterized by loss of bone density & subsequent fractures

Question 3

osteoporosis is sometimes termed…?

Answer 3

silent disease

Question 4

what is most affected in osteoporosis

Answer 4

wrist

hip

vertebral column

Question 5

In osteoporosis is the bone more dense or porous

Answer 5

Porous

Question 6

who is more likely to have osteoporsis….women or me

Answer 6

Women

Question 7

why are women more likey to have osteoporosis

Answer 7

lower calcium intake

less bone mass/smaller frame

bone resorption begins earlier and accelerates at menopause

Increased longevity

Question 8

Risk Factors of osteoporosis

Answer 8

Family Hx

Low body weight <128lbs

corticosteroid use >3months

advanced age

low calcium diet

Lack of weight bearing activity

Smoking

excessive alcohol

Question 9

Clinical manifestations of Osteoporosis

Answer 9

Compression fracture - break in vertebral body of bone due to loss of bone mass. May cause back pain

AND

Progressive Vertebral Deformities

Question 10

number of vertebrae:
Cervical
Thoracic
Lumbar
Sacral
Coccyx

Answer 10

7
12
5
5
4

Question 11

T/F Osteoporosis is preventable

Answer 11

TRUE

Question 12

Adequate calcium intake for osteoporosis

Answer 12

1000mg pre menopausal and post menopauseal taking estrogen

1500 mg for post menopause W/O taking estrogen

Question 13

2 most common calcium supplements

Answer 13

carbonate and citrate

Question 14

What is the preferred method of taking calcium supplements

Answer 14

chewable supplements; take with food

Question 15

How does the body tolerate large doses of calcium

Answer 15

difficult to absorb in single doses > 500 mg

Question 16

What should also be taken with calcium

Answer 16

Vitamin D (800-1000 UI daily)

Question 17

What 3 things do we want to promote in the management of osteoporosis

Answer 17

Load- bearing exercise
-30 min, 3 x week

Avoid tobacco and excessive alcohol

Corset to prevent vertebral collapse

Question 18

Class of Drugs for osteoporosis

Answer 18

Bisphosphonates

Selective estrogen receptor modulator (SERM)

Question 19

MOA of biphosphonates

Answer 19

inhibit osteoclast resorption

Question 20

Bisphosphonate drugs

Answer 20

alendronate (Fosamax)

ibandronate (Boniva)

Question 21

Nursing considerations when taking biphosphonates

Answer 21

take on empty stomach with full glass of water

take 30 min before food/meds

Remain upright x 30 min to prevent esophagitis

Question 22

MOA of SERMs

Answer 22

mimic estrogen effects on bone by reducing bone resorption w/o stimulating breast/uterus

Question 23

SERM drug

Answer 23

raloxifene (Evista)