Osteoporosis Flashcards
what is osteoporosis?
a condition where there is a reduction in the density of the bones
what is osteopenia?
refers to a less severe reduction in bone density than osteoporosis. Reduced bone density makes bone less strong and more prone to fractures.
Risk factors for osteoporosis?
Older age
Female
Reduced mobility and activity
Low BMI (<18.5 kg/m2)
Rheumatoid arthritis
Alcohol and smoking
Long term corticosteroids. NICE suggest the risk increases significantly with the equivalent of more than 7.5mg of prednisolone per day for more than 3 months)
Other medications such as SSRIs, PPIs, anti-epileptics and anti-oestrogens
Key group where osteoporosis should be considered?
post-menopausal women
Oestrogen is protective against osteoporosis. unless they are on HRT postmenopausal women have less oestrogen. They also tend to be older and often have other risk factors for osteoporosis?
What tool gives a prediction of a fragility fracture over the next 10 years?
FRAX tool - usually the first step in assessing someone’s risk of osteoporosis
It involves inputting information such as their age, BMI, co-morbidities, smoking, alcohol and family history. You can enter a result for bone mineral density (from a DEXA scan) for a more accurate result but it can also be performed without the bone mineral density.
It gives results as a percentage 10-year probability of a:
Major osteoporotic fracture
Hip fracture
How is bone mineral density (BMD) measured?
using a DEXA scan, which stands for dual-energy xray absorptiometry
About DEXA scans?
DEXA scans are brief xray scans that measure how much radiation is absorbed by the bones, indicating how dense the bone is. The bone mineral density (BMD) can be measured at any location on the skeleton, but the reading at the hip is key for the classification and management of osteoporosis.
Bone density can be represented as a Z score or T score. Z scores represent the number of standard deviations the patients bone density falls below the mean for their age. T scores represent the number of standard deviations below the mean for a healthy young adult their bone density is.
The most clinically important outcome is the T score at the persons hip. This forms the basis for the WHO classification of their level of osteoporosis. DEXA scans can be used to confirm osteoporosis and monitor treatment.
Normal bone mineral density score: T score at the hip
More than -1
Osteopenia bone mineral density score: T score at the hip
-1 to -2.5
Osteoporosis bone mineral density score: T score at the hip
Less than -2.5
Severe osteoporosis bone mineral density score: T score at the hip
Less than -2.5 plus a fracture
First step for assessing for osteoporosis?
The first step is to perform a FRAX assessment on patients at risk of osteoporosis:
- Women aged > 65
- Men > 75
- Younger patients with risk factors such as a previous fragility fracture, history of falls, low BMI, long term steroids, endocrine disorders and rheumatoid arthritis.
FRAX outcome without a BMD result will suggest one of three outcomes:
Low risk – reassure
Intermediate risk – offer DEXA scan and recalculate the risk with the results
High risk – offer treatment
FRAX outcome with a BMD result will suggest one of two outcomes:
Treat
Lifestyle advice and reassure
Lifestyle Changes:
Activity and exercise
Maintain a healthy weight
Adequate calcium intake
Adequate vitamin D
Avoiding falls
Stop smoking
Reduce alcohol consumption