Osteoporosis Flashcards
Risk Factors 1
- > 65 y/o
- female gender
- low body weight
- cigarette smoking
- nontraumatic fracture
- inactive lifestyle
- family hx of osteoporosis
Risk factors 2
- diet low in calcium or vit. D
- excessive alcohol ( >2 drinks a day)
- postmenopausal
- White and Asian American descent
- low testosterone in men
Risk Factors 3
many drugs can interfere w/ bone metabolism
- Corticosteroids: increases bone loss and stimulates breakdown
- Antiseizure drugs (valproate [Depakote], phenytoin [Dilantin])
- aluminum- containing antacids
- certain cancer tx
-
Corticosteroids
long-term use is a major contributor to osteoporosis
Antiseizure drugs
can affect bone marrow
celebrex (phosphenytoin)
When should a DEXA scan be performed
65 or older for women
not much benefit for men
DEXA Scan
Osteoporosis vs Osteopenia
Osteoporosis = BMD > or equal to -2.5 standard deviations below a young adult BMD.
Osteopenia = BMD > / equal to -1.0 but less than -2.5 standard deviations below a young adult BMD
bone biopsy
can be done to differentiate between osteoporosis and osteomalacia
Bone Mineral Density (BMD)
- normal = >1.0
- osteopenia = -1.0 to < -2.5
- osteoporosis = < -2.5
Osteopenia
more than normal bone loss but not yet osteoporosis
Appropriate Diagnostics
H&P: -hip, vertebra, or wrist fracture
- back pain
- loss of height
- spinal deformities (kyphosis/ stooped posture)
Quantitative US: -sound waves to evaluate bone mass
-may see increased use due to cost effectiveness
Diagnostics cont.
Serum calcium, phosphorus, and alkaline phosphatase may be normal.
alkaline phosphatase may be elevated after fracture
Blood Tests
many used to screen for disease processes that may contribute to osteoporosis
- calcium
- liver function (ALT, AST)
- high TSH (hypothyroidism)
Gold Standard
DEXA scan
CBC
anemia, sickle cell disease, alcohol abuse (with liver function tests)
Serum chemistry levels
- Ca: underlying disease states. Hypercalcemia may reflect underlying malignancy or hyperparathyroidism. Hypocalcemia can contribute to osteoporosis
- creatinine levels may decrease w/ increasing PTH levels or may be elevated in patients with myeloma
- Mg important in calcium homeostasis. Decrease in Mg may affect absorption and metabolism
Calcium Homeostasis
calcium level in blood balanced by:
1. PTH- secreted by the parathyroid gland.
If calcium level is low PTH raises calcium level by stimulating osteoclasts to breakdown bone.
Increases calcium resorption from kidneys.
- calcitonin
secreted by thyroid gland.
If serum calcium too high, calcitonin moves calcium into bones.
Decreases calcium reabsorption.
Two major hormones involved with Calcium
Two antagonistic hormones;
- PTH
- Calcitonin
Calcium- Phosphorus
Relationship
When Calcium is high(> 11.0), phosphorus is low (<3.0)
When phosphorus is high ( > 4.5), calcium is low (< 9.0)
Ca and Phosphorus levels
Calcium= 9.0 - 11.0 Phosphorus= 3.0 - 4.5
Phosphates
used to treat;
- hypophosphatemia
- hypercalcemia
require doctor care
Osteoporosis
“silent thief”
chronic, progressive metabolic bone disease -porous bone -low bone mass -structural deterioration of bone tissue -increased bone fragility -
Etiology and Pathophysiology
bone resorption exceeds bone deposition
most commonly in spine, hips, and wrists
Resorption
loss of bone