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MSK Exam 2 Spring 2015 > Osteoarthritis - Told > Flashcards

Osteoarthritis - Told Flashcards

1
Q

ostearthritis

A

not inflammation

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2
Q

most common arthropathy

A

osteoarthritis

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3
Q

enzyme degradation

A

osteoarthritis

multi-factorial etiology

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4
Q

nodal osteoarthritis

A

genetic

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5
Q

secondary OA

A

due to disorders damaging joint surface

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6
Q

progressive deterioration and loss of articular cartilage - leading to loss of normal joint structure and function

A

osteoarthritis

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7
Q

mechanisms of path in OA

A

1 - damage to normal articular cartilage - physical forces - macro and microtrauma

  • chrondrocytes react - release degradative enzymes
  • inadequate repair

2 - fundamental defective cartilage fails under normal loading - type II collage gene defect - ochronosis

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8
Q

ochronosis

A

type II collagen gene defect
-cannot handle normal loading

get osteoarthritis

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9
Q

pigmented and defective cartilage

A

ochronotic cartilage

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10
Q

sclerosis

A

subchondral bone thickening

-in osteoarthritis

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11
Q

risk fx for osteoarthritis

A 
age
obesity
genetics
gender
menopause - possible hormone issues
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12
Q

common cause of back pain

A

osteoarthritis

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13
Q

DIP osteoarthritis

A

heberdens

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14
Q

PIP osteoarthritis

A

bouchards

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15
Q

1st CMC joint

A

base of thumb

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16
Q

compartments of knee

A

medial, lateral, patellar/femoral

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17
Q

pain in osteoarthritis

A

cartilage - no pain

but get synovitis
capsule/ligament stretching
trabecular microfractures
muscle spasm
intraosseous HTN
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18
Q

stiffness at rest

A

with RA

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19
Q

acute flares of pain

A

crystal disease

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20
Q

systemic sx of OA

A

no

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21
Q

joint pain with movement, slow onset, limited motion and decreased function

A

osteoarthritis

22
Q

cool effusion

A

in osteoarthritis

clear fluid - on aspiration

class I

23
Q

class I synovial fluid

A 
non-inflammatory
clear
high viscosity
form mucin clot
low WBC count
culture negative
24
Q

ESR and RF in OA

A

negative

25
Q

arthroscoped of OA

A

shredded artcilage

26
Q

spondylolysis

A

defect of pars interarticularis

27
Q

spondylolisthesis

A

translated vertebra

28
Q

knee bow out

A

genu varus

29
Q

knock kneed

A

genu valgus

30
Q

coxarthrosis

A

degeneration of hip joint due to OA

31
Q

bunion

A

foot with OA

32
Q

osteophyte

A

bone spur

33
Q

spondylosis

A

degenerative OA of joints between spinal vertebra

34
Q

spondylitis

A

inflammation of vertebra

35
Q

syndesmophytes

A

ligament ossify around vertebra

bamboo spine

36
Q

DISH

A

diffuse idiopathic skeletal hyperostosis

37
Q

exuberant osteophytosis of spine/spans >3-4 vertebral segments

A

DISH

preservation of disc spaces
ligament calcification

associated with diabetes mellitus

more in men

38
Q

anterior cervical osteophytes

A

dysphagia

39
Q

up flowing osteophytes

A

DISH

40
Q

ossification to the tendons

A

causes DISH

41
Q

point of origin for osteophyte

A

enthesis

42
Q

most common spinal ossification

A

right sided

43
Q

dextrocardia

A

left sided ossification

don’t know cause

44
Q

environmental factors with DISH

A

fluoride
synthetic retinoids - acutane
obesity
IGF-1

45
Q

best place to look for DISh

A

thoracic spin

46
Q

upward pointing osteophytes, ligamentous calcification at enthesis, foot and ankle heel spur

A

all characteristic of DISH

47
Q

chrondromalacia of patella

A

with wide Q - angle

wear of medial patella

48
Q

tx goals for OA

A

pain control
improve function
enhance QOL
avoid drug related side effects

49
Q

SMOADs

A

structure modifying osteoarthritis drugs

matrix metalloprotease inhibitiors
residronate
doxycycline
glucosamine
chrondroitin
50
Q

inflammatory osteoarthritis fails to respond to tx

A

think calcium pyrophosphate joint crystals

positive birefringence**

MSK Exam 2 Spring 2015 (10 decks)

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