Osteo Final Flashcards
Name the two different type of bone growth.
Interstitial
Appositional
Growth in length is what type of bone growth?
Interstitial
How does appositional growth occur?
Growth in width, thickness or diameter
How is it that the shaft elongates in long bones?
Cartilage grows at the epiphyseal plate and is replaced by bone.
List the four zones of interstitial bone growth
- Zone of resting cartilage
- Zone of proliferating cartilage
- Zone of hypertrophic cartilage
- Zone of calcified cartilage
In what zone is the cartilage getting ready to die?
Zone of hypertrophic cartilage
What zone is nearest the epiphysis?
Zone of resting cartilage
What is the function of the zone of resting cartilage?
To anchor the epiphyseal plate to the bone in epiphysis.
T or F
In the zone of resting cartilage, chondrocytes are large and condensed
False! Small and scattered
What zone is highly mitotic to replace chondrocytes dying at the diaphyseal end?
Zone of Proliferating cartilage
What do the chondrocytes look like in the proliferating zone?
Large, arranged like stacks of coins.
What happens to the chondrocytes in the zone of hypertrophic cartilage?
Get large and burst. This will change the pH in order to trigger osteoblasts.
How are the chondrocytes arranged in the hypertrophic zone?
In columns
List some properties of the Zone of Calcified Cartilage
- few cells thick
- mostly dead chondrocytes from calcifying matrix
- osteoclasts dissolve cartilage
- osteoblasts and capillaries invade and lay down bony matrix
- epiphyseal plate firmly cemented to bone of diaphysis
When does the bone stop growing?
When the multiplying cartilage stops.
T or F
For most of interstitial bone growth, the epiphyseal plate remains constant in size, but bone lengthens
Very true
What is the first bone to start ossification but the last to stop.
Clavicle - aprox 33 yoa
Most bones complete ossification at what age?
14-19 yoa
Cartilage is replaced on what side of the plate?
Diaphyseal
The presence of what structure means growth has stopped?
Epiphyseal line (bony structure)
What is the first step in appositional growth?
Osteoblasts form ridges around periosteal arteries
Secretion of matrix
Differentiation into osteocytes
In the second step of appositional growth what happens to the ridges formed in step one?
The ridges fuse together
What becomes the endosteum of canal around the artery?
periosteum
What do the osteoblasts build more of to form the osteon in step two of appositional growth?
layers of lamellae