Osteo Final Flashcards
Name the two different type of bone growth.
Interstitial
Appositional
Growth in length is what type of bone growth?
Interstitial
How does appositional growth occur?
Growth in width, thickness or diameter
How is it that the shaft elongates in long bones?
Cartilage grows at the epiphyseal plate and is replaced by bone.
List the four zones of interstitial bone growth
- Zone of resting cartilage
- Zone of proliferating cartilage
- Zone of hypertrophic cartilage
- Zone of calcified cartilage
In what zone is the cartilage getting ready to die?
Zone of hypertrophic cartilage
What zone is nearest the epiphysis?
Zone of resting cartilage
What is the function of the zone of resting cartilage?
To anchor the epiphyseal plate to the bone in epiphysis.
T or F
In the zone of resting cartilage, chondrocytes are large and condensed
False! Small and scattered
What zone is highly mitotic to replace chondrocytes dying at the diaphyseal end?
Zone of Proliferating cartilage
What do the chondrocytes look like in the proliferating zone?
Large, arranged like stacks of coins.
What happens to the chondrocytes in the zone of hypertrophic cartilage?
Get large and burst. This will change the pH in order to trigger osteoblasts.
How are the chondrocytes arranged in the hypertrophic zone?
In columns
List some properties of the Zone of Calcified Cartilage
- few cells thick
- mostly dead chondrocytes from calcifying matrix
- osteoclasts dissolve cartilage
- osteoblasts and capillaries invade and lay down bony matrix
- epiphyseal plate firmly cemented to bone of diaphysis
When does the bone stop growing?
When the multiplying cartilage stops.
T or F
For most of interstitial bone growth, the epiphyseal plate remains constant in size, but bone lengthens
Very true
What is the first bone to start ossification but the last to stop.
Clavicle - aprox 33 yoa
Most bones complete ossification at what age?
14-19 yoa
Cartilage is replaced on what side of the plate?
Diaphyseal
The presence of what structure means growth has stopped?
Epiphyseal line (bony structure)
What is the first step in appositional growth?
Osteoblasts form ridges around periosteal arteries
Secretion of matrix
Differentiation into osteocytes
In the second step of appositional growth what happens to the ridges formed in step one?
The ridges fuse together
What becomes the endosteum of canal around the artery?
periosteum
What do the osteoblasts build more of to form the osteon in step two of appositional growth?
layers of lamellae
What thickens the bone in appositional growth?
Osteoblasts producing circumferential lamellae
Osteoclasts are dissolving bone in the medullary cavity for what purpose?
To enlargen the medullary cavity as the shaft grows outward and to maintain proportions and increase marrow needs.
The law of bone transformation is what law of bone growth?
Wolff’s Law
Describe Wolff’s Law
Bone is laid down where needed to resist compressive and tensile forces and is removed where not needed in order to achieve the greatest economy of tissue
Is Wolff’s law used to explain everyday normal use?
No. Comes into play when the actions of the bones are traumatic ex) training for a marathon.
Heuter Volkmann Principle states that there is a direct relationship between what factor and the rate of growth of the epiphyseal cartilage?
Static compressive forces parallel to the longitudinal axis
What does Volkmann’s principal imply?
That compressive forces may be important factors regulating the growth of epiphyseal cartilage and even long bone lengths.
Vargus is a term describing what characteristic in the human skeleton
Bowleggedness
Knocked knees is also known as?
Valgus
What sex steroids will develop the secondary skeletal sexual characteristics?
Estrogens and androgens
What hormone is especially known to shut down growth plates?
Estrogen
List the three hormonal influences on bone growth
Insulin-like growth factor
Human Growth hormone
Sex steroids
What vitamin is important for the differentiation of osteoblasts into osteocytes?
Vit C
What vitamin will stimulate the activity of osteoblasts?
Vit A
The vitamins responsive for protein synthesis are?
Vit K & B
What happens to the bone when osteoblasts are overactive?
Abnormally thick and heavy bone - arthritic lipping, calcium spurs.
Weakened bone tissue is the result of…
hypoactive osteoblasts
What is a major cause of osteoporosis
Hyper activity of osteoclasts = weakened bone tissue
The condition resulting from the bone matrix calcification being incomplete or absent is known as?
Rickets
What is a telltale sign in young children with Rickets?
Bowing of femur
What are the two varieties of Rickets discussed in class?
Vit D deficiency - responds to supplementation
Vit D resistant - caused by errors in metabolic pathways of calcification. Does NOT respond to supplementation
What is often called the adult form of Rickets?
Osteomalacia
What is the etiology of Osteomalacia?
Osteoid not adequately mineralized
What are some causes of Osteomalacia?
Inadequate dietary calcium
Vitamin imbalances
Hormonal imbalances
Pregnancy and lactation
The condition in which the amount of actual bone matrix per volume is reduced is known as?
Osteoporosis
What is cortical involution?
Compact bone becomes thinner
Is Osteoporosis a single disease?
No!
- postemenopausal: loss of anabolic hormones
- senile: due to old age
- disuse: due to lack of mechanical loads
- idiopathic: no readily observed cause, can affect anyone at any age.
What is the “Marble bone disease”
Osteopetrosis
Describe Osteopetrosis
- Abnormally large amounts of bone matrix and highly mineralized bone matrix
- Very thick cortical bone
- Dense network of cancellous bone
- Large amounts of calcified cartilage
- Bone is very brittle and easily fractured (high bone mineral to collagen fibre ratio)
- Systemic
What disease is similar to osteoporosis but more localized?
Paget’s
What disease is characterized by soft brittle bones and is an inherited autosomal dominant trait?
Osteogenesis Imperfecta
Giantism is the result of what metabolic influence?
High hGH usually the result of pituitary disorders
Another name for open fracture is…
Compound
A simple fracture can also be called…
Closed fracture
What type of fracture is when the bone is shattered?
Comminuted
What type of fractures do we see in growing bones?
Greenstick
The fracture of the tib and fib is called…
Pott’s
Where does Colle’s fracture happen in the body?
Wrist
The type of fracture more commonly found on flat bones is called?
Depressed
The first step in healing fractures involves the formation of?
A fracture hematoma aka blood bandaid
What happens to the capillaries in the area of the fracture in the first step of healing?
Capillaries grow - bringing osteoclasts and phagocytes
T or F
In step one of fracture healing circulation continues to the site of injury keeping nearby bone alive.
False - circulation stops at site of injury and nearby bone cells die.
After the blood bandaid forms what forms next?
Fibrocartilagenous callus - turns blood bandaid into cartilage.
What is a pro callus?
Actively growing connective tissue
What cell will produce collagen to “glue” the fracture together?
Fibroblasts
The procallus will become what type of callus?
Fibrocartilaginous
After the fibrocartilaginous callus is formed the next step is to form?
Bony callus
In fracture healing the trabeculae production will be important to join what tissues together?
Living to dead
Initially what type of bone is formed in the bony callus
Woven bone - embryonic bone
What is the final stage in healing a fracture?
Bone remodelling: dead portions of bone resorbed, compact bone replaces spongy bone, callus smoothed out and often barely detectable.
In the bone remodelling stage of fracture healing, compact bone replaces spongy bone where?
At periphery and where previously found callus.
In the fracture healing process, the hematoma lasts approx. how many days?
7 Days
What are the 2 main categories of joint classification?
Physiological
Anatomical
Structural or composition is a description of what classification?
Anatomical
What are the three types of anatomical classifications?
Fibrous, Cartilaginous, Synovial
Physiological classification of joints categorizes into two more properties what are they?
Function and degree of movement
Name the the sub types of the physiological category of joints.
Synarthrosis
Amphiarthrosis
Diarthrosis
A joint cavity filled with fluid would have what physiological and anatomical classification?
Diarthrosis and Synovial
What does amphiarthrosis mean? Give examples
A joint joined by either cartilage or cartilage and fibrous tissue. Ex: Primary epiphyseal plates of growing bones and secondary types like the intervertebral discs.