OSSIFICATION RORS Flashcards
FACTORS THAT AFFECT OSSIFICATION
GENES
VITAMINS
HORMONES
NUTRITION
THE BASIC FACTOR IN OSTEOGENESIS AND MORPHOGENESIS
GENES
WHAT DOES GENE DETERMINES?
- site of osteogenesis and presence and absence of cartilage model
- normal timing and order in which ossification happen
- time of cessation of growth
DEFECTIVE CALCIFICATION OF CARTILAGE AND OSTEOID TISSUE
VITAMIN D
CARTILAGE CELLS HYPERTROPHY AND PERSIST
EPIPHYSIAL DISK BECOME THICK AND IRREGULAR
IF THERES MORE OSTEOID TISSUE
APPEAR KNOBBY “RACHITIC ROSARY”
RATE OF OSSIFICATION IS REDUCED
VITAMIN A
DEFECTIVE PRODUCTION OF FIBERS AND GROUND SUBSTANCE AND OF PHOSPHTAE IN BONE
VITAMIN C
OSTEOBLASTIC INTERFERENCE
VIT C
SOMATOTROPHIC
GROWTH HORMONE
DELAYS THE CLOSUR OF THE EPIPHYSIS BY PROLIFERATION OF CARTILAGE CELLS AT THE EPIPHYSEAL DISK
SOMATOTROPHIC
GIGANTISM
HYPERSECRETION OF STH
DWARFISM
HYPOSECRETION OF STH
HYPERSECRETION AFTER CLOSURE OF THE EPIPYSEAL PLATE
ACROMEGALY
MATURATION OF BONE
THYROID HORMONE