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IMS: Histology > Ossification > Flashcards

Ossification Flashcards

1
Q

What are the 2 types of ossification?

A
  • intramembranous

- endochondral

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2
Q

What bones are formed by intramembranous ossification?

A
  • clavicle

- most cranial bones

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3
Q

What is the 1st type of bone cell in IO?

A

Mesenchymal cells

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4
Q

In the 1st step of IO, what do mesenchymal cells do?

A

Cluster together

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5
Q

1st Step of IO: What do mesenchymal cells differentiate into?

A

Osteoblasts

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6
Q

1st Step of IO: What is the term for the site of cluster?

A

Ossification centre

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7
Q

1st Step of IO: What do osteoblasts secrete?

A

Extracellular matrix

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8
Q

2nd Step of IO: What do osteoblasts differentiate into?

A

Osteocytes

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9
Q

2nd Step of IO: What process occurs which involves the hardening of the extracellular matrix?

A

Calcification

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10
Q

2nd Step of IO: What mineral is deposited?

A

Calcium

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11
Q

3rd Step of IO: What T is formed?

A

Trabeculae

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12
Q

3rd Step of IO: Trabeculae fuse together to form what type of bone?

A

Spongy/cancellous bone

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13
Q

3rd Step of IO: Connective tissue associated with blood vessels in the trabeculae differentiates into ?

A

Red bone marrow

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14
Q

4th Step of IO: What is formed at the edge of the bone from mesenchyme?

A

Periosteum

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15
Q

What types of bone are formed using intramembranous ossification?

A

Flat

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16
Q

4th Step of IO: What type of bone tissue replaces the spongy bone, only at the surface?

A

Compact bone

17
Q

4th Step of IO: What type of bone tissue remains in the middle of the bone?

A

Spongy bone

18
Q

4th Step of IO: What type of bone cell is used to destroy and reform the bone?

A

Osteoclasts

19
Q

Which types of bones are formed by Endochondral Ossification?

A

Long bones

20
Q

1st Step of EO: What do mesenchymal cells differentiate into?

A

Chondroblasts

21
Q

1st Step of EO: what do chondroblasts secrete?

A

cartilage extracellular matrix

22
Q

1st Step of EO: What does the cartilage model mostly consist of?

A

Hyaline cartilage

23
Q

2nd Step of EO: Once chondroblasts are deeply buried in the matrix, what are they called?

A

Chondrocytes

24
Q

2nd Step of EO: How does growth of the cartilage model occur?

A

Cell division of chondrocytes

25
Q

2nd Step of EO: What process occurs?

A

Calcification

26
Q

2nd Step of EO: Why do some chondrocytes begin to die?

A

Nutrients cannot diffuse through the matrix

27
Q

2nd Step of EO: What are the spaces called which are left due to the dead chondrocytes?

28
Q

3rd Step of EO: What develops in the diaphysis of the bone?

A

Primary ossification centre

29
Q

3rd Step of EO: What replaces most of the cartilage?

A

Bone tissue

30
Q

4th Step of EO: What bone cells break down the bone to form the medullary cavity?

A

Osteoclasts

31
Q

4th Step of EO: What is most of the wall of the diaphysis replaced with?

A

Compact bone

32
Q

5th Step of EO: What develops in the epiphysis of the bone?

A

Secondary Ossification centre

33
Q

6th Step of EO: What 2 things are formed:

A
  • Epiphyseal plate

- Articular cartilage

34
Q

6th Step of EO: What do the epiphyseal plate and articular cartilage both consist of?

A

Hyaline cartilage

IMS: Histology (3 decks)

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