OSCE Study Book Questions

Question 1

Which of the following is a RF for rapid cycling mania?

1. Hyperthyroidism 2. Bipolar II Disorder 3. Male gender 4. Depressive episode at onset 5. Shorter duration of illness

Answer 1

Bipolar II Disorder. Rapid cycling is a specifier of the longitudinal course of bipolar I or II Disorders.

Question 2

What is defined as 4 mood episodes within 12 months that meet the criteria for a manic, Hypomania, or major depressive episode. Episodes are demarcated by partial or full remission for at least 2 month or by a switch to an episode of opposite polarity. RF include; female gender, bipolar II subtype, longer duration of illness, family Hx of mood disorders, clinical or sub clinical hypothyroidism, poor response to lithium, use of antidepressants

Answer 2

Rapid cycling mania specifier

Question 3

Which of the following statements is true about buspirone?
1. It is a partial 5HT antagonist 2. It brings with high affinity to benzodiazepine receptors 3. It has anticonvulsant properties 3. It does not cause sedation in the elderly

Answer 3

Does not cause sedation in the elderly.

Question 4

Buspirone hydrochloride is an anxiolytics. What receptors does it act on and what receptor does it not bind to?

Answer 4

Binds to 5HT and does not bind to GABA.

Question 5

What are the major SE of Buspirone?

Answer 5

HA, nausea, dizziness, and tension.

Question 6

What are the rare SE of buspirone?

Answer 6

Tachycardia, palpitations, CP, drowsiness, confusion, and seizures

Question 7

Which of the following is not associated with ECT?

Answer 7

1. Arrhythmia 2. BP changes 3. ECG changes 4. Permanent neuro deficits 5. Prolonged seizures

Question 8

Which of the following is true about mono amine oxidase inhibitors (MAOIs)? 1. The antidepressant activity of MAOIs is directed toward mono amine oxidase B inhibition 2. Mono amine oxidase A specifically binds to serotonin

Answer 8

Mono amine oxidase A specifically binds to serotonin.
MAOIs differ from each other in enzyme activity. There are 2 subtypes of MAO enzymes; A and B. MAOa binds to 5HT/NE and MAOb binds to phenylethylamine.

Question 9

Which of the following statements is true about GABA receptors? 1. They are predominant excitatory receptors in the CNS 2. GABAb receptors are G protein - coupled receptors.

Answer 9

GABAb receptors are G protein coupled receptors

Question 10

GABA is the major ______ (inhibitory/excitatory) NT in the CNS

Answer 10

Inhibitory

Question 11

BZDs exert their action by potentiating the activity of _______ receptors

Answer 11

GABAa

Question 12

BZD binding increases the frequency of opening of the ______ ______ complexed with the _____ receptor.

Answer 12

Chloride Channel. GABAa.

BZD increases the frequency of opening of the chloride channel complexed with the GABAa receptor.

Question 13

GABAb receptors increase ______ levels via G protein coupling

Answer 13

potassium

GABAb receptors increase potassium levels via G protein coupling

Question 14

GABAc receptors are direct coupled receptors with ligand gated ______ ____ channels

Answer 14

Chloride ion

GABAc receptors are direct coupled receptors with ligand gated chloride ion channels.

Question 15

Methadone is a ______ (full/partial) opiate agonist

Answer 15

FULL

Methadone is a full opiate agonist

Question 16

Buprenorphine is a _______ (full/partial) opiate agonist

Answer 16

Partial

Buprenorphine is a partial opiate agonist.

Question 17

Does naloxone or naltrexone have a longer duration of action?

Answer 17

Naltrexone

Question 18

Which of the following is not a temperamental variable as define by Alexander Thomas? 1. Activity level 2. Distract ability 3. Low adaptability 4. Intensity of reaction 5. Regularity

Answer 18

Low adaptability is not a temperamental variable

Question 19

What are the nine temperamental variables?

Answer 19

Activity level, persistence, distractibility, initial reaction, adaptability, mood, intensity of reaction, sensitivity or sensory threshold, regularity or rhythmicity

Question 20

Is absent tendon reflexes a feature of normal sleep?

Answer 20

Yes

Question 21

What are the features of normal sleep (6)

Answer 21

Absent tendon reflexes, increased BP, gastric motility, cerebral BF, irregular resp, penile erection