OSCE Conditions Flashcards
What is Crohn’s Disease?
Inflammation of the GI tract
What is UC?
Inflammation of the colon and rectum
Give some symptoms of IBD
Diarrhoea- blood, mucous, pus Abdo pain Increased frequency of bowel movements Fatigue Weight loss
Explain why patients with IBD feel tired
Inflammation of the bowel leads to blood loss which leads to anaemia which causes tiredness
They may also not be able to absorb nutrients in their gut as well as they used to leading to malnutrition and tiredness.
Give some causes of IBD
Genetics
Western diet and environment
Smoking
Autoimmune destruction of gut flora
How is IBD diagnosed?
Blood tests- inflammation, anaemia, infections Stool sample Colonoscopy Barium enema CT/MRI
Give 3 ways IBD can be treated
Surgery- remove section of inflamed bowel (ileostomy)
Corticosteroids- prednisalone
Immunosuppressants
Biological therapies - infliximab
Give some complications of Crohn’s disease
Fistulas Bowel strictures Anaemia Osteoporosis Colorectal cancer
Give some complications of UC
Osteoporosis Poor growth Toxic megacolon Bowel cancer Primary sclerosing cholangitis
Explain how bowel strictures can occur in IBD
Chronic inflammation results in deposition of scar tissue. This builds up and narrows the bowel lumen causing strictures
Through what structures do fistulas form in Crohn’s disease?
Bowel and vagina, bladder or skin
What is cerebrovascular disease?
Diseases caused by poor blood flow to the brain
What are the 3 most common cerebrovascular diseases
Stroke
TIA
Vascular dementia
What is an ischaemic stroke?
Blockage of blood flow to the brain by a clot causing brain damage due to hypoxia
What is a haemorrhagic stroke?
Leakage of blood into the brain tissue
Give 3 symptoms of a stroke
Slurred speech
Drooping face
Loss of sensations in the arms
What is vascular dementia?
Loss of mental ability due to lack of perfusion to the brain
What is a TIA?
A transient ischaemic attack
Temporary disruption to the blood flow to the brain. Very similar to a stroke but resolves within 24 hours
Give 5 risk factors for cerebrovascular disease
Smoking Obesity Stress Atrial fibrillation Hypertension Poor diet Hypercholesteraemia Diabetes Excess alcohol
What are gallstones?
Aggregations of cholesterol in the gallbladder
When do gallstones become a problem?
When they become lodged in a duct
Give the main symptom of uncomplicated gallstones
Biliary colic- abdo pain which cannot be relieved, usually lasts a few hours
Give 4 symptoms of complicated gallstones
Biliary colic + Tachycardia Fever Diarrhoea Itchy skin Sweating Jaundice
Give the 2 main causes of gallstone formation
Hypercholesteraemia
Hyperbilirubinaemia
Give 4 risk factors for gallstones
Female Over 40 years old Obese IBS Genetics Taking ceftriaxone
What sign on examination would suggest gallstones?
Positive Murphy’s sign
Push on liver and ask patient to take deep breaths
If gallbladder is inflammed it will cause pain
What tests can be done to diagnose gallstones?
USS CT MRI Cholangiography Blood test- CRP, leukocytes
How are gallstones treated?
Painkillers
Control with low fat diet
Cholecystectomy
What can poorly managed gallstones lead to?
Acute pancreatitis Gallbladder cancer Jaundice Acute cholecystitis Acute cholangitis
What is acute kidney injury?
Sudden onset of kidney damage
Give 2 causes for pre-renal AKI
Hypertension
Liver failure
Give 2 causes for ATN
Infection
Ischaemia
Iatrogenic
Give 2 causes for post-renal AKI
Urinary stones
Enlarged prostate
Tumour
Give 3 medications which may precede AKI
ACE inhibitors
NSAIDs
Diuretics
Give 4 symptoms of AKI
Nausea Vomiting Abdo. pain Dehydration Confusion Increased blood pressure
Explain how an AKI can lead to increased blood pressure
An AKI will result in the kidney not functioning properly and therefore retaining electrolytes and water. This will increase the blood volume and therefore the blood pressure
How can an AKI be diagnosed?
eGFR
U+Es
Urine output
Blood creatinine
How can AKIs be treated?
Prevent dehydration
Find the underlying cause
Stop medications which may be causing kidney damage
What acid base balance change is likely to occur in AKI and why?
Metabolic acidosis- the kidney cannot excrete a range of acidic anions due to the lack of function leading to a decrease in pH in the blood
Why can AKI lead to pulmonary oedema?
Lack of water excretion by the kidney leads to an increased blood volume and blood pressure. The increased blood pressure from the body can put pressure on the left atrium. The blood backs up and it pushed out into the lungs to causes pulmonary oedema.
What is alcoholic liver disease?
Chronic liver damage due to excessive alcohol intake
What are the 3 severities of alcoholic liver disease?
Alcoholic fatty liver disease
Alcoholic hepatitis
Cirrhosis
Of the 3 stages of alcoholic liver disease, which are reversible?
Alcoholic fatty liver disease
Alcoholic hepatitis
Give 4 early symptoms of alcoholic liver disease
Nausea Vomiting Fatigue Abdo pain Loss of appetite Diarrhoea
Give 4 advanced symptoms of alcoholic liver disease
Ascites Fever Hair loss Weight loss Nosebleeds Clubbing Jaundice Vomiting blood
Give the 2 causes of alcoholic liver disease
Frequent binge drinking
Long term excessive drinking
Give 3 factors which as well as excessive alcohol intake, put patients at a greater risk of alcoholic liver disease
Obesity
Female
Pre-existing liver disease
Family history
How is alcoholic liver disease diagnosed?
LFTs MRI CT X-ray Liver biopsy Endoscopy
What is the main treatment of alcoholic liver disease?
Stop drinking alcohol
Give an intervention questionnaire which can be used to assess alcohol intake
CAGE
Cut down?
Annoyed by people commenting on your drinking?
Guilty about volume of alcohol?
Eye-opener? (Do you need alcohol in the morning?)
Give a pharmacological treatment of alcoholic liver disease
Corticosteroids
Give 4 complications of alcoholic liver disease
Liver cancer
Ascites leading to peritonitis
Portal hypertension
Oesophageal varices –> bleeding –> anaemia
What is the definition of anaemia?
Lack of haemoglobin in the blood causing poor oxygen transport and therefore hypoxia
Give 5 symptoms of anaemia
Pale Fatigue Feeling cold Lightheadedness Short of breath Palpatations
Give 3 causes of microcytic anaemia
Iron deficiency
Thalassaemias
Anaemia of chronic disease
Give 3 causes of normocytic anaemia
Sickle cell anaemia
Blood loss
Anaemia of chronic disease
Give 3 causes of macrocytic anaemia
Haemolytic anaemia
B12/folate deficiency
Bone marrow failure
Give 3 sources of iron in the diet
Spinach- green, leafy vegetables Fish Meat Lentils Eggs Nuts
How can anaemia be diagnosed?
Full blood count
Blood microscopy
Identify area of blood loss
Give 3 signs on examination of anaemia
Pale palmar creases
Pale conjunctiva
Angular stomatitis
Glossitis
How can anaemia be treated?
Treat underlying cause:
Eg. Prevent blood loss, Iron/B12 supplements
What is asthma?
Narrowing of the airways due to inflammation and excessive production of mucous
Give 4 triggers of an exacerbation of asthma
Cold air Chest infections Exercise Stress Allergies Night time
Why do asthmatics have worse symptoms at night?
Less cortisol (due to circadian rhythm) which is an anti-inflammatory Exposure to dust mites in bed clothes Lying flat- mucous drains along respiratory tract
Give 4 symptoms of asthma
Wheeze
Breathlessness
Tight chest
Coughing
What is the difference between a stridor and a wheeze?
A wheeze is heard on inspiration and a stridor is heard on expiration
What is an asthma attack?
A severe exacerbation of all the asthma symptoms plus tachycardia, confusion, drowsiness, central cyanosis, severe tight chest
Give 2 causes of asthma
Family history
Passive smoking as a child
Premature birth
How is asthma diagnosed?
Spirometry
Peak flow test
Allergy test
Which 2 conditions are strongly associated with asthma
Eczema
Hayfever
How can asthma be treated?
Step 1: Short-acting Beta-2 antagonist - Salbutamol
Step 2: Inhaled Corticosteroid
Step 3: Long-acting beta-2 antagonist- Salmeterol
Step 4: Inhaled corticosteroid and a long acting beta-2 antagonist
Step 5: Increase doses
Step 6: Add an oral corticosteroid
How do beta-2- antagonists work to treat asthma?
Bind to beta-2 adrenergic receptors in the airway to cause blocking of adrenaline which results in bronchodilation
What is atrial fibrillation?
The atria do not beat in a regular rhythm as they become independent of the pacemaker. The atria do not go into systole for long enough and therefore the heart fills less. The heart beats faster to compensate.
Give 3 cardiac causes of atrial fibrillation
Hypertension Atherosclerosis Mitral stenosis Congenital HF Pericarditis
Give 3 respiratory causes of atrial fibrillation
COPD Asthma CO poisoning Pneumonia PE
GIve 3 triggers for an exacerbation of atrial fibrillation
Excess of alcohol Obesity Caffeine excess Smoking Drugs
How is atrial fibrillation diagnosed?
ECG
Echocardiogram
Pulse rate
Blood test- anaemia/thyroid levels