Orthopaedics Flashcards
Give 5 risk factors for development of osteoporosis?
Increasing age Family history Steroid use long term Hyperthyroidism Hyperparathyroidism Hypercalcuria Alcohol use Smoking BMI <22 Reduced testosterone Early menopause Renal failure Liver failure Erosive or inflammatory bone disease Low dietary calcium Malabsorption Immobility Previous fragility fracture Type 1 diabetes
What is the DXA cut off for diagnosing osteoporosis?
T score of -2.5 or less
What are the indications for performing a DXA scan?
Over 50 years old and a history of fragility fractures
Less than 40 years old with a major risk factor for fragility fracture
10 year fracture risk of 10% or more
How is osteoporosis managed?
Lifestyle advice eg stop smoking, do more exercise, reduce alcohol intake, do balance exercises
Bisphosphonate treatment
Calcium and vitamin D supplements if appropriate
HRT if premature menopause to reduce fracture risk
What are the main features of joint hypermobility syndrome?
Joint hypermobility with chronic pain related to exercise
What is the pathology involved in Paget’s bone disease?
Abnormal, increased, osteoclast activity with increast bone resorption
Followed by abnormal osteoblast activity with excess bone formation with bone that is less organised, less compact, more vascular and weaker with increased risk of fractures
Which bones are most affected by Paget’s disease?
Axial skeleton inc. pelvis
Long bones
Skull
Give three common complications of Paget’s disease?
Bone pain Bone deformity Pathological fractures Increased bleeding from fractures Osteoarthritis Deafness and tinnitus
Give three uncommon complications of Paget’s disease
Paraplegia Spinal stenosis Nerve compression Hypercalcaemia Hydrocephalus High output cardiac failure Osteosarcoma
What are the features of a bone profile blood test in Paget’s disease?
Normal calcium, phosphate and PTH
Increased Alkaline Phosphatase
What are the features of Paget’s disease on X ray?
Multiple multifocal sclerotic patches giving a cotton wool appearance
Osteolysis
Excess bone formation
Patchy cortical thickening
V shape at boundary of healthy and abnormal bone
How is Paget’s disease managed?
Analgesia
mobility aids
Bisphosphonates with vit D and calcium deficiency correction
Surgery if deformity, nerve compression or fractures
How does renal failure cause bone disease?
Reduced production of 1,25-vitamin D Reduced resorption of calcium and reduced absorption of dietary calcium Reduced phosphate excretion Raised PTH due to hypocalcaemia These act to increase bone reabsorption
What biochemical abnormalities are present in osteomalacia?
Reduced calcium Low phosphate High Alk Phos High PTH Low vitamin D \+/- anaemia
What are the radiological features of osteomalacia?
Coarsened trabelculae
Osteopenia
Pseudofractures of low density with sclerotic border
Give 3 risk factors for the development of osteomalacia
Dark skin >65 House bound or institutionalised Pregnancy Obesity Routine covering of face and body Poverty Vegetarianism Alcoholism Family history
What is osteomalacia?
Inadequate mineralisation of bone matrix due to vitamin D deficiency
What are the main symptoms of osteomalacia?
Persistent fatigue
Bone pain and tenderness
Proximal myopathy
Costochondral swelling
How is osteomalacia managed?
Dietary advice and increased sunlight exposure Treat any underlying condition Analgesia Calciferol Vit D supplements Monitor calcium, vit d and PTH
What is the difference between the diaphysis, metaphysis and epiphysis?
Diaphysis = shaft of long bone Metaphysis = area of spongy bone adjacent to epiphysis Epiphysis = place of secondary ossification and bone growth
Where does haemopoiesis take place in adults?
In interstitium of short bones and metaphyseal ends of some long bones
Name a bone which develops by intramembranous ossification?
Clavicle
Where is hyaline cartilage found?
Articular surfaces
Where is white fibro-cartilage found?
Midline structures eg intervertebral discs and symphyses