Orthopaedic Implant Mechanics & Materials Flashcards
What are orthopaedic implant devices made from?
Non-biologic materials, usually metals (stainless steel, titanium alloy, cobalt chrome alloy)
What are the 2 general reasons for an implant device?
- provide structural support after injury
2. replace diseased bone
What materials are used in joints for implant devices, and why?
Metal and plastic materials (usually HDP).
Metal to metal contact has been unsuccessful as a bearing surface.
What is the main problem with implant devices and why?
Infection - bacteria is attracted to and adheres to metal and cement surfaces. The immune system works less efficiently in the presence of implants
What are the 5 criteria for a successful orthopaedic implant?
- but not have any short-term and little long-term adverse toxic effects e.g. carcinogenesis
- relieve pain and provide sufficient mobility
- function without failure until it is no longer required
- have a design which predict a guaranteed outcome
- cost-effective
2 main structural requirements for an orthopaedic implant
strength & stability
What structural factors must be considered during implant design?
- strength
- stiffness
- lubrication
- wear
- fatigue
What kinematic factor must be considered during implant design?
Motion - must enable daily living functions, whilst being controlled to enable stability
What are the requirements of an orthopaedic implant that are essential for biocompatability?
- Biological integration - the implant must not react with body tissues at unsafe levels, and body tissues should not corrode the implant at an excessive rate
- Functional integration - the implant shouldn’t affect the function of other body parts
What does the term ‘composite structure’ mean in terms of orthopaedic implants and their structural behaviour?
Most orthopaedic implants attach themselves to bone and form a composite structure.
A composite structure therefore is made up of more than one material.
The structural behaviour of a composite material depends on the mechanical properties of both individual materials.
Describe the difference in shape at the end regions of bones, and explain why?
The end regions are wider - this accommodates for the joint
What type of bone is found in the end regions of bones, and explain why?
Cancellous bone - more porous and flexible, so has desirable shock absorbing qualities
How are the trabeculae arranged in cancellous bone?
Aligned along the directions of greatest stress (the directions depend on the directions of natural load placed on the bone)
What is the composition of the bone directly below articular surfaces, and explain why?
More dense than the cancellous bone below it, in order to provide a dense underlying surface for the joint so it doesn’t deform under loading.
Is the Young’s Modulus for a structural material always constant?
It depends - only if the material is not deformed near or over its elastic limit.
Non-biologic structural materials are isotropic - what does this mean?
The mechanical properties of the material are the same no matter what direction it is loaded.
Bone is anisotropic - what does this mean?
Its Young’s modulus is dependent on the direction it is loaded.
Under what direction of loading is cortical bone stiffest and strongest - longitudinal or transverse?
Longitudinal (for all types of loading - tensile, compressive, shear)
Compare the strength of bone in the diaphysis (shaft of a long bone) to the metaphysis (near the ends of bone)?
Bone strength at the metaphysis is around half of that of the diaphysis.
Under what type of loading is bone strongest and weakest?
Strongest - compressive loading
Weakest - shear loading
Bone is viscoelastic - what does this mean?
The stiffness of bone changes with the rate it is loaded. The faster it is loaded the stiffer it becomes.
Does bone have the same value of maximum stress for different types of loading?
No - it has different values of ultimate stress depending on the type of loading (compressive - strongest, shear - weakest)
In terms of implant design, what ways of loading bone are sought to be avoided?
Avoid shear stresses especially, as well as tensile forces.
Aim to load the bone under compressive forces.
Compare the Young’s modulus of cancellous bone to that of cortical bone?
Cancellous bone has a very variable Young’s modulus - from a maximum of 50% of that of cortical bone to less than 0.5%.
Why is it not desirable to create an implant with such a wide range of stiffness like cancellous bone?
- Increased infection risk with such an increase in surface material
- a more flexible material may not provide adequate firmness for attaching or bonding an artificial joint
Explain the concept of ‘stress shielding’ in terms of artificial implants?
After insertion of implants, parts of the bone which the implant is attached to experience a reduction in loading as the weight is now shared between the bone and the implant.
Due to the bone being able to alter its mechanical properties in response to loading, bone is resorbed where it is not needed.
What are the consequences of stress shielding in orthopaedic implants?
Stress protection and consequential resorption of bone results in a breakdown between implant and bone, and ultimate loosening of the implant.
Replacement of the implant then becomes an issue, as the original bone has been lost due to resorption so fixation is a problem.
What is the most major role of all orthopaedic implants?
Provide structural support
Do all types of implants have the same principals/mechanisms of loading bearing?
Yes, on the most part
What are the 2 main types of load support mechanisms in orthopaedic implants?
- Load transfer
2. Load sharing
Explain the term ‘load transfer’?
Part of the applied load (e.g. body weight) in the bone above is transferred to the plate/stem of implant.
Explain the term ‘load sharing’?
Occurs in a middle region, where there is load sharing between the bone and the plate/stem.
Does load transfer occur along the whole of the bone-implant interface?
No!
Load is transferred only at screw regions (where there is a plate device), and at the end regions of a stem (in a stem implant).
When load transfer is occurring in composite materials, what are the 2 possible outcomes that can occur at the interface?
- Interface stresses - occurs when the materials are bonded together.
- Relative movement - occurs when the materials are not bonded together, or the bond has come loose.
Load transfer can occur under which types of loading?
- Compressive loading
2. Shear loading
Explain load transfer under compressive loading when the bottom material is more flexible than the top material?
The bottom material compresses and expands more laterally than the top material.
If the materials are bonded - lateral strain at the interface is the same for both materials, and a shear stress is generated at the interface because one material is trying to expand more than the other.
If the materials are not bonded - sliding occurs
Explain load transfer under compressive loading when the top material is more flexible than the top material?
The top material compresses more than the bottom material.
The highest levels of stress at the interface occur under the region of the applied load.
When shear stresses are generated at interfaces, is the shear stress constant across the whole length of the interface?
No - only at areas where there is load transfer (generally at the ends of the bar). The middle portion is where load sharing occurs, so no shear stresses are generated here.
Why can interface stresses be much higher than theoretical calculations?
- Non-uniformity of contact
2. Non-uniformity of mechanical properties - stiffness, stress concentrations
What is the most common loading type of implant situation to cause osteopenia (bone loss)
Situations where stress shielding occurs i.e. when load transfer occurs in 2 stages (in between is a portion of load sharing).
What factors determine how much load is transferred from bone to plate and vice versa?
It depends how much load is shared in the load sharing region.
This in turn depends on the stiffness of each component.
What 2 factors determine the structural stiffness of a structural component involved in orthopaedic implantation?
- its material stiffness
2. its geometric stiffness
What is the ‘material stiffness’ of a structural component?
Stiffness of the material under an axial or bending load - indicated by Young’s modulus (E)
Stiffness of the material under shear loading - indicated by Shear Modulus (G)
What is the ‘geometric stiffness’ of a structural component?
The force required to produce a unit deflection (k) - concerned with the cross-section of the shape.
What is the formula for calculating stiffness (k) of a structural component?
k = EA / L
What are the geometrical factors that affect the axial stiffness of a structural component?
- cross-sectional shape
- length
(based on the equation for stiffness)
When is it appropriate to use Rigidity as a method for indication of stiffness of a structural component?
When length is not a consideration for indicating stiffness, for example when comparing two intramedullary nails or plates of the same length.
What is the equation for axial rigidity?
R = E x A
where
E = young’s modulus
A = area
What is the equation for bending rigidity?
R = E x I
where
E = young’s modulus
I = second moment of area
What is the second moment of area?
A measure of how resistant a structure is to bending.
The further away a material is from the neutral axis the more rigid it is when bent.
i.e. the higher I, the more rigid the structure.
What is the equation for torsional rigidity?
R = G x J
where
G = shear modulus
J = polar second moment of area
What is the polar second moment of area?
A measure of how resistant a structure is to torsion.
What is the name of the contact area between the implant fixator and bone?
What is the most important quality that this contact area must have?
Bone-implant interface
Must be fixed and free from movement to prevent loosening and ultimate failure
How is fixation between implant and bone achieved?
By different methods, depending on whether the implant is to be removed at a later date.
What is the main use for screws in the fixation of orthopaedic devices?
Mainly for fracture fixation
Why are nuts and bolts rarely used for attaching implants to bone?
Causes more trauma, as needs to be access to bone from both sides (one for the bolt, the other for the nut)
Explain the fixation technique of ‘interference fit’?
Doesn’t have a specific fixation device, and relies on a tight fit between the implant and bone to give enough friction to prevent movement. The inner component is usually slightly larger than the outer component.
What is the consequence of an interference fit being made too tight?
The bone will split
In what fixation situation is ‘interference fit’ used as a method?
Cementless joint replacements
What is the main purpose of using bone cement in fixation?
To act as a filling material between bone and implant, so perfect match is not required. Does not act as an adhesive!
When is bone cement most commonly used?
In stems of joint replacements
Why is bone cement currently used instead of adhesives?
It is too difficult to apply adhesives - the bones are wet and it would be too difficult to prepare the bones prior to application of adhesive
What is ‘biological fixation’?
Materials coated onto the surface of implants which are porous, or mesh-like and therefore encourage bone to grow into this coating and form a lock between the bone and the implant
What are the 2 main methods of biological fixation?
- using beads of the same material as the metallic implant
2. using a ceramic, eg hydroxyapatite (HAp), the main mineral constituent of bone
Explain the method of using metallic beads in biological fixation?
There are small pores between spherical beads which encourage bone to grow into them.
What is a disadvantage of using metallic beads in biological fixation, and what is done to overcome this?
The metal is very exposed, and is susceptible to corrosion, especially crevice corrosion.
The technique is mainly used with titanium stems, as titanium is least corrosive.
Explain the method of using ceramics such as hydroxyapatite in biological fixation?
Hydroxyapatite can be sprayed directly onto the metal implant using a technique called plasma spray coating.
What is a disadvantage of using ceramics in biological fixation?
Only a short term solution - after 1 or 2 years there is loosening, which is thought to be due to some of the coating disappearing.
Define a ‘biomaterial’?
A non-biological material, which is used in the body normally to repair/replace failed body parts
It is important that a biomaterial has a high biocompatability - what does this mean?
Interacts well with the body.
What are the 2 main factors which affect biocompatibility?
- body fluids interaction with the material - usually corrosion, which ultimately leads to failure
- effect of the material on body tissues - tends to cause abnormal changes, like allergy, ulceration or cancer.
Define corrosion?
Progressive unwanted removal of a material by an electrochemical process.
Occurs when 2 solid materials which conduct electricity (electrodes) are placed in a liquid which conducts electricity (electrolyte). An electric current flows from one metal to the other through the liquid, allowing a chemical reaction to take place between the electrode and the electrolyte –> galvanic corrosion.
How does corrosion occur in orthopaedic implants?
Implants are electrodes because they are either metal, or some other conductive material (like carbon in carbon fibre reinforced plastics).
Body tissues act as electrolytes, as they contain salts which are very corrosive.
The corrosion causes loss of the implant material, which will cause high stress concentrations and ultimate fatigue failure of the implant.
When is a corrosion reaction most severe - when two metal electrodes are the same or different?
Different
Under what circumstances can an implant made of one alloy behave as two electrodes and lead to corrosion?
If there is a non-homogenous region within the component, which can arise if there is inclusion of impurities in the metal, or a non-uniform distribution of alloy material.
What is the main step taken to reduce corrosion of metal implant?
Mixing metals together to form alloys, rather than using pure metals (apart from titanium, which is corrosion resistant in its pure form).
What are the only 3 alloys used in implants?
Stainless steel alloys
Cobalt chrome alloys
Titatanium alloys
Why are metal alloys and titanium metal good for resisting corrosion?
They form a thin passivation layer composed of metal oxide which forms as a product of corrosion, but acts to seal the underlying material from further corrosion.
What is ‘fretting corrosion’?
Corrosion which occurs as the result of abrasion between materials in contact, which removes the protective metal oxide layer.
In what situation does fretting corrosion occur?
It occurs when there is repetitive rubbing of materials which are not meant to have any movement between them
e.g. between screws and plates, and in interference fits
What is ‘crevice corrosion’?
Corrosion which occurs in crevices between implants, where body fluids get trapped and loses its oxygen supply. As a result there is a build-up of acid which corrodes the implant
What areas are prone to crevice corrosion?
Edges of bone plates and between screws and plates
What are the 2 methods used on metal implants to improve corrosion resistance?
- Nitric acid immersion
2. Titanium nitride coating
What is a recent development in metal corrosion resistance of implants?
The effect of niobium reducing corrosion on 316L stainless steel.
Give 7 adverse effects of implanted materials on the human body?
- Growth of a thin fibrous layer between the implant and body tissue.
- results due to micromotion
- means bone and implant are not fixed together - Local infection.
- presence of foreign material suppress’s body’s ability to fight infection - Body sensitisation to metals.
- Inflammation in regions where corrosion has occurred.
- metal oxide layer is lost and there is contact between metal particles and body tissues. - Tissue necrosis in regions of bone cement.
- Immune reaction due to wear particles from surfaces of joint replacements.
- leads to cell-mediated bone resorption (poorly understood) - Tumours at implant site (long-term)
What is the most common type of stainless steel used for implants?
316L grade stainless steel - a low carbon steel (0.3% carbon)
Why is a low-carbon steel preferred for implants?
To reduce sensitisation of tissues and therefore make it more resistant to corrosion.
What are the main elements making up 316L grade stainless steel?
Iron Chromium Nickel Molybdenum Manganese Silicon, Sulphur, Phosphorus (very small amounts)
Is 316L grade stainless steel completely corrosion resistant?
No - can corrode and crack and high stress and is prone to corrosion resistance
What type of implants is 316L grade steel most suitable for?
Temporary implants, like in fracture fixation (screws and plates)
How are 316L grade stainless steel implants usually made, and why is this method chosen?
They are forged - heated metal is forced into shape by hammering.
Used because it makes the metal up to 4 times stronger than steel produced by casting.
What is a disadvantage of forging 316L grade stainless steel?
Steel becomes less ductile, so has a lower fatigue strength.
Why are cobalt chrome alloys preferred to stainless steel for permanent implants?
They have better corrosion resistance, although they are not as strong
What was the original cobalt chrome alloy used in orthopaedics? What is its composition?
Stellite 21
- 65% cobalt
- 30% chromium
- 6% molybdenum
What is a disadvantage of cobalt chrome alloys? What has been done in an attempt to overcome this?
They are not as strong as stainless steel
- other alloys with superior strength (MP35N) have been tried, but they don’t have as good corrosion resistance.
Despite cobalt chrome alloys being less strong than stainless steel alloys, why are they preferred for large permanent implants?
The replacement part is large enough to provide sufficient strength.
Why are stainless steel alloys preferred to cobalt chrome alloys for temporary fixtures, like fracture fixation plates?
The cross-sections of the implants are very small, and cobalt chrome alloys are not strong enough to support.
In pure titanium implants, what process is carried out before implantation?
Anodisation (increasing the thickness of the anti-corrosion layer on the surface)
What mechanical properties of titanium make it the most suitable for use in implants?
Less dense (lighter) and half as stiff than stainless steel or cobalt chrome alloys.
Higher fatigue strength than stainless steel.
What part of a joint replacement is titanium not used for and why?
The bearings in joint replacements - has a low wear resistance.
What are fibre-reinforced plastics?
Composite materials used in fracture fixation, which use very stiff, high strength, but brittle fibres embedded in a flexible resin material.
What is the main advantage to using fibre-reinforced plastics in orthopaedic implants?
Have a very high strength, but a very low stiffness, so are very mechanically compatible to bone.
When did the first attempts at joint replacement begin?
In the 19th century, when prolonged anaesthesia became possible.
Why did the first attempts at joint replacements fail?
There was only an attempt to replace the surfaces of joints - which couldn’t support the large load placed on them. The materials used incl. gold and leather caused high infection and rejection rates.
What was the first recorded successful hip replacement?
A “Thompson” hemi-arthroplasty:
Replaced the femoral head with steel. Had a long stem driven down into the femoral canal (“press fit”)
Explain the work by McKee and Farrar in the 1950s in the UK?
Were among the first to carry out a “total arthroplasty”.
Developed a metal acetabulum which had small projections on its outer surface.
This was “press fitted” together with a Thompson like femoral stem.
Why did the work by McKee and Farrar ultimately fail?
They developed a metal-on-metal total arthroplasty, which had high levels of friction as a result. There were excessive shear forces transferred to the bone prosthesis which caused loosening.
In the 1950’s, what were the Judet brothers from France known for?
They were the first to use polymethylmethacrylate (PMMA) in an arthroplasty. This plastic was used to make a femoral head, which was held in place with a small peg in the femur.
What is the importance of John Charnley in hip joint replacement?
He was the first to develop a low friction total joint arthroplasty in the early 60s.
What were the most important contributions to joint replacement design by Jon Charnley?
- Designed a smaller femoral head:
- reduce bearing friction and loosening - Introduced the use of bone cement (first was PMMA) between bone and prosthesis:
- help to distribute load - Introduced high-density polyethylene (HDP) as a bearing material:
- lower friction bearing - Produced a system of instrumentation to match his prosthesis
List the 5 performance criteria for an orthopaedic implant?
- Tolerated within the body and provide no short-term and little long-term adverse effects.
- Give pain relief and allow return of normal daily activities.
- Adequate life-span, ideally out-living the patient.
- Should be insertable by a competent surgeon of average ability such that a predictable outcome can be reasonably guaranteed.
- Should be of acceptable cost.
To what extent do hip arthroplasty’s meet this performance criterion:
tolerated within the body and provide no short-term and little long-term adverse effects?
Most hip joints are made from cobalt chrome or titanium, which are fairly corrosion resistant.
HDP provides a good bearing surface, but it does give undesirable tissue reaction when fragmented.
To what extent do hip arthroplasty’s meet this performance criterion:
give pain relief and allow the return of normal daily activities?
There is no actual cure or long-term pain relief that is suitable without causing a high risk of side effects, therefore hip replacement is the most effective way of relieving pain and restoring function.
What type and range of motion are required from the hip in order to be able to stand, walk and sit down?
- slight extension
- min flexion of 30 degrees
- abduction when weight bearing
- rotate when in full extension
To what extent do hip arthroplasty’s meet this performance criterion:
have adequate life-span, ideally out-living the patient?
Generally - 90% will last 10 years.
To what extent do hip arthroplasty’s meet this performance criterion:
should be insertable by a competent surgeon of average ability such that a predictable outcome can be reasonably guaranteed?
An advantage with hip arthroplasty is that only an approximate reciprocal shape is needed as the remaining space is filled with PMMA to act as a filler between bone and prosthesis, meaning that this op is well within the ability of the surgeon.
To what extent do hip arthroplasty’s meet this performance criterion:
Should be of acceptable cost?
Raw material costs are low, as are manufacturing costs.
However, the product is a low volume production item and labour intensive, but not over-expensive.
Why is it important to determine the forces acting on the normal hip structure in designing a hip prosthetic implant?
Knowing the forces allows for the stresses to be calculated, which can then be used in the design process of the prosthesis.
What are the 2 main contributors to force in a joint?
- External loads
2. Muscle forces acting at the joint
What are the 2 main experimental methods of estimating stress?
- Strain gauges (experimental method)
2. Finite Element Analysis (computerised method)
The Finite Element Analysis has mostly replaced experimental methods in estimating stresses. What is involved in this method?
Creation of a 2D or 3D model of the structure made up of small elements. Loads are then applied to the model and the computer calculates the stresses.
What are the advantages of using the Finite Element Analysis in calculating stresses?
Ease of calculation of stresses.
Designs can be compared.
Regions of high stress can be easily identified.
Give 2 reasons why it is so difficult to determine accurately the stresses in the components of a replacement hip?
- Joint loading varies according to the physical activity being undertaken.
- magnitude varies greatly because the hip has a wide range of movement. - The magnitude of muscle forces for different activities cannot be determined accurately.
- if more than one muscle is active, there are more unknown forces than equations to solve them.
Which type of activity generally generates the largest joint reaction force in the hip: walking ascending stairs descending stairs rising from a chair
ascending stairs (around 7.2x BW)
Which type of activity generally generates the smallest joint reaction force in the hip: walking ascending stairs descending stairs rising from a chair
rising from a chair (around 3x BW)
What is meant by an indeterminate structure?
When it is not possible to calculate forces because there are more unknown forces than equations to solve them (like in the hip joint if more than one muscle is active).
What activity can be used to help analyse stresses in hip prostheses?
Standing on one leg - some muscles are not active at all (so their force values are 0), leaving the abductor muscles to be calculated.
It also generates high bending stresses.
What types of stresses arise in the hip joint?
- Compressive stresses
- Bending stresses
- Hoop stresses due to bending
- Torsional stresses
- Stresses in the acetabulum
How does compressive stress in the femur arise?
How is it calculated?
The hip joint force has a component which causes a compressive force in the femur, giving rise to a compressive stress.
Compressive stress = F/A,
where F = compressive force, A = cross-sectional area
What happens to compressive stresses in the femur when a prosthesis is present?
The compressive force from the stem is transferred to the femur as a shear force.
What is the consequence of a stem-bone bond not being sufficiently strong enough?
The prosthesis will loosen and sink into the medullary cavity.
How are compressive stresses in a hip prosthesis stem calculated?
F/A
where F = compressive load at any section
A = area of that cross-section
Is the compressive load taken by a hip prosthesis stem uniform along its length?
No, it varies (due to load transfer and stress shielding)
What methods are utilised to prevent a hip prosthesis stem from sinking distally into the medullary canal?
- tapering the stem
- using a collar at the proximal stem
- fixing the bone to the stem, using bone ingrowth or adhesion
- using a cement strong enough to withstand shear forces
What methods are utilised to reduce interface shear stresses in a hip prosthesis by converting shear loads to compressive loads?
- using a collar at the proximal stem
- tapering the stem
What methods are utilised to avoid fracture of the hip prosthesis stem?
- use a stem with a large enough cross-section to resist the stresses
- use a high-strength material for the stem
What method is utilised to prevent excess stress shielding in a hip prosthesis?
Careful selection of the rigidity of the stem under axial loading.
What causes a bending stress in the femur?
The direction of the joint force vector is not along the neutral axis, so the femur is subjected a bending moment and therefore also a bending stress.
What is the equation for calculating bending stress?
Bending stress = My / I
where
M = the applied bending moment
y = the distance from the neutral axis to the section of interest
I = second moment of area
Draw a normal femur showing the main forces acting on the bone and how they contribute to producing a bending stress in the bone?
(diagram - draw)
The force required by the abductor muscles is around 2BW. This creates a bending moment, which produces tension on the lateral side of the femur and medial compression.
Draw a femur with an implanted stem to illustrate the main forces acting and how they contribute to produce an bending stress in the stem?
(diagram - draw)
To keep the stem in static equilibrium, the applied load due to the joint force must be balanced by reaction forces due to contact between the stem and the femur.
The proximal area on the medial side of the femur provides one main contact point and the lateral distal side provides another, which counteracts the tendency for the stem to rotate due to the bending action of the joint force.
The max bending moment (M) occurs in the proximal stem, and equals joint force (J) x d. Moving down the stem, the moment decreases to zero at the distal end.
How does the presence of a femoral stem affect the magnitude of the bending stresses in the femur?
Reduces the stresses in the proximal end of the femur as the stem takes some of the bending load from the bone
List the important design features of a femoral stem that are important to ensure the stem does not fail under a bending load?
- design it with a large enough second moment of area
- design its shape to limit the magnitude of the bending moment due to the joint force
List the important design features of a femoral stem that are important to prevent the stem loosening under a bending load?
- provide a good enough strong bond between bone and stem or cement
- provide a good press fit
List the important design features of a femoral stem that are important to minimise stress shielding of the bone under bending loads?
- select a suitable rigidity for the stem
Describe what is meant by a ‘hoop stress’?
A hoop stress is also known as a circumferential stress, which is generated under the act of a bending load.
It results from radial stresses, which are stresses that directed out radially from a central point. Hoop stresses in the bone are primary tensile stresses that act in a direction that tend to split the bone.
Where are radial stresses greatest?
points of bone-stem contact at the proximal and distal ends
It has been shown that radial stresses are:
a) proportional
b) inversely proportional
to the square of the length of contact of the stem with the bone?
What does this mean for radial stresses in stems of short length?
Inversely proportional.
Stems of short length are prone to high radial stresses on the bone.
Give 2 examples of how hoop stresses occur?
- if the stem is too short
- if there isn’t a good fit of the stem in the medullary cavity
How do torsional stresses within the femur occur?
When the ankle is restrained and the upper body is rotated, the femur experiences a torsional load like the lower leg and knee.
Give 4 examples of how shear stresses in stems can be converted into compressive stresses?
- use non-circular stems
- high shear strength of cement (if used)
- good bonding at interfaces
- surface treatments of the stem to improve interface bonding
Why is it desirable to use non-circular sections for the stem of a femoral component?
To reduce the rotational shear stress.
Why does the normal acetabulum have a high bending strength?
Due to its structure - it is a sandwich of cancellous bone in between two layers of cortical bone, one of which is covered with articular cartilage and forms the joint bearing surface.
Therefore it a lightweight but with good rigidity.
List 5 important design factors for an acetabulum replacement?
- size and conformity of joint replacement surfaces
- affects contact areas, which affects contact stresses - ways to maintain the subchondral cortical bone
- if this broken, the cancellous bone, which isn’t normally loaded, takes most of the load - stiffness and thickness of the cup
- whether or not to use a cup with a metal backing plate
- the technique used to fix the cup to the remaining acetabular bone.
What is bone cement made from?
Polymethyl methacrylate (PMMA) - a polymer
What is the benefit of coating a prosthesis component with PMMA during manufacturing?
The cement filler adheres better to the implant during surgery, and forms a stronger bond therefore a greater resistance to shear forces.
Give two advantages of using cement in a hip replacement?
- The surfaces between bone and implant do not need to be an exact fit, as the gaps can be filled with cement.
- Cement fills in all the gaps between bone and prosthesis, preventing areas of high stress concentrations.
List 3 problems with PMMA cement?
- As the cement polymer sets, the temperatures are high enough to destroy body tissue next to the cement, to a depth of a few cm.
- There is always some monomer left after the chemical reaction, which is very toxic and these small fragments cause intense inflammatory reactions.
- Cement is a filler, and doesn’t chemically bond to bone or stem, so any tensile loading parts the cement from the bone and stem, ultimately leading to cement fatigue failure.
Why is a non-bonded interface undesirable?
- Still a significant amount of abrasive wear as bone rubs against metal.
- There will still be a layer of fibrous tissue forming between the bone and the interface, unless the bonding is absolutely perfect, which is hard to achieve with a press fit.
- There is still a small amount of motion between the surfaces, which causes wear particles to be released into tissue.
List 3 ways to improve the integrity of the cement interfaces with bone and metal stems?
- Roughen the stem surface or coat with beads -
improve interlocking of cement to the prosthesis. - Coat the prosthesis with PMMA -
bonds to the inserted cement to give an intimate fit. - Combine PMMA surface coating with a cement that bone can bond to -
cement containing hydroxyapatite.
Explain briefly the mechanism of load transfer from the stem to the femur, with particular reference to the regions of high interface shear stresses?
Load is transferred from stem to bone as a shear force.
Shear stress is highest at the ends of the stem (where load transfer occurs). The magnitude of shear stress is dependent on the magnitude of the shear force, which in turn depends on how much load is transferred to the bone proximally and distally e.g. the great the proximal load transfer from stem to bone, the greater the proximal shear stress.
Explain the influence of stem rigidity on the magnitude of the proximal interface shear stresses?
Using a stiffer stem reduces the proximal shear stress (because less load is transferred from the stem to the bone proximally), however this increases stress shielding of the bone.
It also increases distal shear stress, because more load will be transferred to the bone distally.
What is an ‘isoelastic stem’?
Why can they not be used in hip prostheses?
A stem with the same stiffness as bone.
They are good for stress shielding, however they increase the shear stress too much at the proximal end of load transfer, and can be high enough to cause failure of bonding at the interface.
What is the magnitude of stresses in cement dependent on?
Its thickness and its stiffness.
What risks are associated with using a cement layer that is too thin?
- very high cement stresses
2. bone resorption at the proximal femur (due to cement debris causing an adverse tissue reaction)
What is considered to be the optimal thickness for a cement layer?
3-7mm proximally, 2mm distally
What effect does the use of a proximal collar have on load transfer from the stem to the femur?
Allows compressive load transfer from the stem to the bone, reducing stress shielding and lowering the stresses in the cement in the proximal medial region.
What is the main argument against using a collar in femoral stems?
The collar-calcar contact area acts a pivot, about which the stem can rotate.
This means the distal end of the stem is prone to high stress concentrations.
Cementless stems are now surface coated - usually with hydroxyapatite. What is the main advantage of completely coating the surface of a stem, as opposed to just partial coating?
- Helps bone ingrowth and potentially eliminates metal debris from bone-metal abrasion.
- Gives opportunity for the bone to bond to a larger area.
Cementless stems are now surface coated - usually with hydroxyapatite. What is the main disadvantage of completely coating the surface of a stem, as opposed to just partial coating?
Fully coated stems promote stress shielding of the bone.
How does a ‘tapered wedge’ stem help proximal load transfer?
Allows transfer of a significant amount of load in compression, rather than shear.
Name the 2 ways that the neck of a femoral stem can be modified in order to reduce the bending moment at the stem?
What effect do these modifications have on the hip joint force?
- Reduce the length of the neck of the stem
- Increase the angle between the long axis and the axis of the neck
- These increase the hip joint force, giving rise to greater wear and acetabular stresses.
Which of the following affect the frictional force on a bearing:
a) contact load
b) contact area
c) material properties of the surface to which the load is applied
d) material properties of both surfaces?
contact load and material properties of both surfaces
Why is high-density polyethylene (HDP) used as a bearing surface in replacement joints, when there are other polymers which have a much lower coefficient of friction?
It is one of the least toxic and best wearing as a bearing surface.
What are the two types of wear that occur between bearing surfaces?
Adhesive wear and Abrasive wear
When does adhesive wear occur between bearing surfaces?
The two bearing surfaces stick together when they are pressed together, and the softer one is torn off by the harder one.
Bearing surfaces should be made of materials with low levels of adhesion.
When does abrasive wear occur between bearing surfaces?
When surfaces are not perfectly smooth, therefore highly polished surfaces are very important
What are the 3 factors which affect the amount of wear that takes place in a bearing?
v = c.N.s / p
where
v = volume of wear
c = constant (the coefficient of wear)
N = applied load of the bearing surfaces
s = the distance of the bearing slides
p = the hardness of the surface being worn
What is HDP’s main disadvantage as a bearing material?
HDP wear fragments can migrate considerably within an implant, which can cause intense inflammatory tissue reactions and is associated with aseptic loosening.
Give 2 reasons why small diameter heads are used in hip replacements?
- They reduce cup-bone interface shear stresses, which lessens the risk of loosening.
- They produce less volume wear of HDP than large diameter heads
What are the 2 main disadvantages of using a small diameter head in hip replacements?
- The rate of depth of wear is greater than what it would be for a larger head because contact area is less.
- There is an increased likelihood of dislocation in post-op period because there is increased likelihood of neck impingement on the edge of the cup
What is the acetabular component usually made of?
HDP, +/- a metal backing between it and its interface with cement or bone.
Give some important features in the design of modern acetabular cups?
- size of femoral head and acetabular cup
- HDP may or may not be lined with a metal backing plate
- thickness of the HDP layer
- outer dimension of the acetabulum
Give 3 acetabular design features that affect the contact pressure at the bearing surface of the hip joint?
- diameter of the cup
- the radial clearance
- thickness of HDP
Why is there a minimum recommended thickness to the HDP cup?
This means the point contact load between the femoral head and the cup is spread out over a greater area and avoids excessive contact stress on the HDP.
What is the advantage of using an acetabular component with a metal backing plate?
Holds the plastic in place and reduces its tendency to creep and distort, avoiding high contact stresses on the HDP.
What are the 3 steps that lead to acetabular component loosening due to HDP fragments?
- HDP fragments come into contact with bone
- Tissue reaction to the HDP leads to bone resorption.
- The HDP migrates further along the interface, causing further resorption.
The knee joint has a surface which does not provide much stability. What does the joint rely on for stability?
- ligaments
- integrity of the posterior joint capsule
- musculature
List the names of the 4 principal knee ligaments?
Anterior cruciate ligament (ACL)
Posterior cruciate ligament (PCL)
Medial collateral ligament (MCL)
Lateral collateral ligament (LCL)
What is the origin and insertion of the ACL?
What is its main stabilising role?
Origin - the anterior intercondylar region of the tibia
Insertion - posterior femur, in the intercondylar fossa.
Resists anterior subluxation of the tibia over the femur.
What is the origin and insertion of the PCL?
What is its main stabilising role?
Origin - the posterior intercondylar region of the tibia
Insertion - anterior femur, in the intercondylar fossa
Resists posterior subluxation of the tibia onto the femur.
What is the origin and insertion of the LCL?
What is its main stabilising role?
Origin - lateral femoral condyle
Insertion - lateral fibular head
Resists adduction of the joint
What is the origin and insertion of the MCL?
What is its main stabilising role?
Origin - medial femoral condyle
Insertion - medial tibia surface
Resists abduction of the joint
The four ligaments of the knee act together to provide what 2 general stabilsing roles?
- limit distraction of the knee
- limit long axis rotation of the joint
What is the posterior capsule of the knee joint?
What is its role?
a band of tendinous material running across the posterior surface of the knee.
resists hyperextension
How can the LCL and the MCL contribute to knee instability?
- the LCL is longer than the MCL.
- the MCL and the LCL can both become lax.
In terms of knee joint motion, how do the lengths of the ligaments change with flexion/extension?
They don’t! The ligaments move nearly isometrically.
Describe how the axis of rotation of the knee changes with flexion?
The vertical line which passes through the centre of rotation moves horizontally.
As the knee flexes, the centre of rotation moves posteriorly, as does the point of surface contact of the femur and tibia.
The centre of rotation in the knee joint is also known as…?
Instantaneous centre of rotation. - it changes at every instant of motion.
The cruciate ligaments are responsible for the four-bar linkage mechanism the knee joint. What is this?
This constrains the motion of the femur on the tibia so that there is a combination of rolling and sliding motion.
Explain how the cruciate ligaments act as a four-bar linkage mechanism?
The rolling distance required by the knee joint to reach its maximum flexion of 140 degrees is considerably high (>55 mm).
However, the range of rolling motion actually achieved by the knee is constrained within around 20mm (the distance the instantaneous centre of rotation moves from extension to full flexion).
This limit to the rolling distance is provided by the cruciate ligaments, and has the effect of controlling the position of the most posterior point of the centre of rotation, to allow the knee to fully flex without rolling up against the posterior capsule.
Why is the joint reaction force at the knee much greater than body weight?
The external forces are mostly compressive, and the contacting femoral/tibial surfaces have the combined effects of:
- gravitational forces,
- contracting forces of the muscles and
- the balancing loads of the ligaments.
Explain why the medial knee compartment is more heavily loaded during activities such as walking?
As well as a vertical component of GRF which acts compressively, there is also a horizontal component.
During gait the horizontal component is directed medially to the knee, creating an adduction moment which must be balanced by muscles and ligaments.
At a low magnitude of horizontal GRF, the quadriceps acting via the patellar tendon can hold the joint together.
At higher magnitudes, the hamstrings are also used which increases the joint reaction force. They dont have the strength to maintain contact at both condylar surfaces.
There is loss of contact from the lateral side, and the load is then taken by the medial condyle. Stability is now relied upon from the LCL to balance the moment.
What 2 adverse effects could a high contact force in the medial compartment of the knee have on a joint replacement?
1) the tibial component needs to be able to transfer medial compartment loads to the bone without causing stresses that could cause the bone to fail.
2) If the LCL is absent or can’t be retained during surgery, then the knee prosthesis has to provide all lateral stability (usually in form of a hinge).
Nearly all knee replacements are made of which materials?
Femoral component - cobalt chrome
Tibial component - HDP
Compare the results of knee to hip in terms of longevity without failure?
Knee replacements now have almost the same results as those for hip replacements - this has happened in the last 10-15 years.
90-95% ten year survival rate
List the 3 important functional kinematic requirements of a knee prosthesis?
- Should extend to 180 degrees so that person can stand without effort by quadriceps.
- Should flex to 90 degrees.
- Should permit slight axial rotation to maintain natural ligament tension throughout flexion/extension.
Why is the femur cut at about 7 degrees for proper alignment of the femoral component?
The 2 bearing surfaces in the knee must be cut parallel.
The femur has to be cut at an angle to compensate for the natural angulation of the femur relative to the tibia. (see diagram on pg 9)
What must happen to the posterior capsule of the knee in a knee replacement, and why is this done?
Must be dissected off the back of the femur.
To allow the replacement knee to fully extend.
Why must the collateral ligaments be balanced in equal tension in a knee replacement?
To keep the joint cuts in parallel and prevent any excess medial or lateral opening of the joint.
Compare the cost of hip and knee replacement?
Knee costs around 5x more than hip replacement.
Define the term ‘constraint’ in the context of knee replacements?
Refers to the relationship between the tibial and femoral bearing surface geometries.
The more constrained they are, the less freedom of movement they have to slide and rotate.
What is a ‘fully constrained’ knee prosthesis?
a replacement with linked prostheses, like a hinge between the tibial and femoral component.
What is an ‘unconstrained’ knee prosthesis?
a surface replacement - tibial or femoral.
What is a ‘semi-constrained’ knee prosthesis?
a prosthesis with a constraining mechanism only active in certain degrees of extension
Why is it not helpful to describe modern knee replacements in terms of constraint?
All replacements have some degree of constraint in their movement, and most modern knee replacements fall in to the semi-constrained category.
When is it suitable for a hinged knee prosthesis to be used?
When there are no ligaments intact - the hinge constrains the knee to a single axis of motion so ligaments are not required.
What is the main problem with hinged prostheses?
Prone to loosening - there is no give under lateral loading and rotational loading.
If the PCL is not to be retained in knee replacement, what design consideration for the prosthesis must be taken into account?
Since the PCL controls the rolling motion of the tibia, a mechanism must be built into the prosthesis to enable the femur to rotate on the tibial plateau without sliding too posterior.
What are the advantages to retaining the PCL in knee arthroplasty?
1) provides some antero-posterior stability and proprioceptive activity
2) walking on stairs is more stable
What are the disadvantages to retaining the PCL in knee arthroplasty?
1) Prevents a free surgical dissection of the posterior capsule, which therefore may limit full extension
2) Encourages the femoral component to slide over the tibial bearing which can cause wearing
What are the advantages to removing the PCL in knee arthroplasty?
1) allows for more congruent joint surfaces, which reduces HDP wear.
2) allows for any deformity correction
Why does a replacement knee need to have a fairly flat tibial plateau when the PCL is retained?
A flat tibial plateau helps provides a kinematic design that allows the PCL to function properly.
In a PCL retaining prosthesis, what are the consequences if the PCL is too loose?
Allows forward movement of the femur on the tibia so the rolling back motion no longer works
In a PCL retaining prosthesis, what are the consequences if the PCL is too tight?
1) restricted flexion, and excessive rolling back of the femur on the tibia.
2) compression of the joint surfaces, leading to contact stresses.
What are the main problems with high density polyethylene (HDP) material in knee arthroplasty?
1) its wear debris has an adverse effect on bone tissue, leading to resorption
2) oxidises over time leading to increase in density which causes increased stiffness
3) greater stiffness increases joint contact stresses, leading to wear
4) prone to fatigue failure under loading
What is the purpose of using stems and pegs on femoral and tibial components of a knee prosthesis?
To maintain a large area of contact to prevent loads producing stresses large enough to loosen the interface
- long stems constrain the motion of the prosthesis to do this.