Ortho Splinting Flashcards
What are osteoblasts derived from?
Mesenchymal cells
What do osteoblasts produce?
- Osteocalcin (which needs Vit D)
- Type I collagen
Osteoblasts are affected by:
- ILs
- Platelet derived growth factor
- Insulin derived growth factor
Describe osteoclasts
- Multinucleated giant cells
- Attach to bone by integrins (decreases acidity, proteolytic digestion)
- Specific receptors for calcitonin (helps regulate resorption)
What do osteoclasts originate from?
Hematopoetic tissue (monocyte progenitors)
What is organic bone matrix composed of?
- Collagen (90% of organic matrix, tensile strength)
- Proteoglycans (inhibit mineralization, partially responsible for compressive strength)
- Non-collagenous proteins (osteocalcin, osteonectin, osteopontin)
What is inorganic bone matrix composed of?
- Calcium Hydroxyapatite (responsible for compressive strength)
- Osteocalcium Phosphate (brushite)
What type of bone makes up 80% of the skeleton?
Cortical bone
Describe cortical bone
- 80% of skeleton
- Haversian canals (nutrient supply)
- Stress oriented formation
Describe cancellous bone
- Trabecular (spongy)
- Higher rate of remodeling
What are the non-collagenous proteins in organic bone matrix?
- Osteocalcin
- Osteonectin
- Osteopontin
Describe immature bone
-Not stress oriented
-Elastic in nature
(embryonic skeleton, fracture healing)
Describe pathologic bone
-Random organization
-Weak
(tumors)
Stages of fracture healing
- Inflammatory (bleeding/hematoma)
- Repair (primary callous at 2 weeks, bridging)
- Remodeling (complete when repopulation of marrow space
When does primary callous occur in fracture healing?
2 weeks
Initial response of fracture healing is to:
Decrease blood flow
How does bone differ in kids?
- Thicker periosteum
- Cambium has increased ability for osteoblast formation
Why shouldn’t a cast be put on the first few hours following a fracture?
Inflammatory response causes bleeding/hematoma and casting it could cause compartment syndrome
What is Wolff’s Law?
- Bone remodeling
- Decreased stress = decreased density
- Piezoelectric charges (compression which stimulates osteoblasts, tensile which stimulates osteoclasts)
Salter Harris Classification
I: transverse through physis II: through physis w/metaphysis fragment III: physis w/epiphysis fragment IV: epiphysis, physis and metaphysis V: crush injury to physis
When does blood flow begin to increase and when does it return to normal after a fracture?
- Begins to increase hours-days after fracture
- Returns to normal 3-5 months