Ortho Flashcards
what is multiple myeloma?
- malignancy of plasma cells
- accumulation in bone marrow
- Ig secretion in the blood or urine + associated tissue / end organ damage
what type of cell is a myeloma plasma cell?
post-germinal centre plasma B cell
what type of protein may be secreted in the urine by myeloma plasma cells?
bence jones proteins
- deposition of theses in distal tubules in kidney causes kidney disease
summarise management of a patient with multiple myeloma:
Non-pharam
- MDT
- annual influenza vaccine + one off pneumococcal vaccine
Pharma
- analgesia (avoid NSAIDS due to renal impairment)
- chemo
- corticosteroid
- bisphosphonates
- thromboprophylaxis
Other
- blood transfusion
- local radiotherapy
- stem cell transplantation
what is pancytopenia?
condition in which a person’s body has too few red blood cells, white blood cells, and platelets
an injury involving the anatomical snuff box is most likely to damage the?
radial artery
this nerve can be compressed when passing through the cubital fossa.
can cause
- numbness and tinging in the 4th and 5th fingers.
ulnar nerve
patient with an anterior shoulder dislocation may hold their arm:
- externally rotated
- slightly abducted
patient with posterior dislocation of shoulder may hold their arm?
- internally rotated
- slightly adducted
the spine of scapula is found at what vertebral level:
T3
the most inferior aspect of scapula is found at what vertebral level:
T7
the most superior aspect of iliac crest is found at what vertebral level:
L4
the posterior superior iliac spine is found at what vertebral level:
S2`
what is Pagets disease?
- accelerated rate of bone turnover
- subsequent rapid new bone formation
- bone does not have normal matrix and is disorganised
what is the pharmacological mainstay of treatment for Pagets disease:
bisphosphonates
- inhibit osteoclast activity , cause osteoclast apoptosis
example
- Zoledronic acid (IV infusion)
- alendronate (oral)