Origins of German outbreak strain of E.coli

Question 1

What is common pathogenicity feature of enterohemorrhagic E.coli?

Answer 1

enterocyte effacement pathogenicity island

Question 2

What is common virulence feature for Enteroaggregative E.coli?

Answer 2

AggR transcription factor

promotes expression of virulence genes such as AAF (aggregative adherence fimbriae)

Question 3

What was uncommon about the EA strain of german outbreak 2011?

Answer 3

Was EA strain - confirmed by 3rd gen seq

but encoded for Shiga toxin 2 (not common 2 EA)

Question 4

What central African strain was the outbreak strain thought to be similar to?

Answer 4

55989 strain

similar symptoms but did not produce shiga toxin

Question 5

What other strain was comparatively sequenced along with outbreak strain and central African isolates?

Answer 5

TY2482

Question 6

whats the good sentence you should try and memorise to make yourself sound smart about the severity of this outbreak

Answer 6

This case is an extreme example of lateral transfer leading to an accretion in synergistic virulence factors

Question 7

whos the best

Answer 7

I am the best

Question 8

whos gonna pass the exam

Answer 8

me