Organic synthesis Flashcards
1
Q
Route from alcohol to carboxylic acid
A
Heat in Reflux with acidified potassium dichromate
2
Q
Haloalkane to amine
A
You don’t go directly to amine due to further substitution
Haloalkane to nitrile: KCN (ethanol) & heat
Nitrile to amine: H2, Ni, 200•c or LiAlH4
3
Q
Alkane to haloalkane
A
Halogen (X2)
Uv light
Nucleophilic substitution
4
Q
Alkene to alcohol
Alcohol to alkene
A
Alkene to alcohol:
Concentrated H3PO4 & high T and P
Alcohol to alkene:
Conc H2SO4
180•c
5
Q
Amine to amide
A
Acyl chloride/ acid anhydride
6
Q
Haloalkane to alcohol
A
NaOH(aq)
Warm nucleophilic substitution
7
Q
Alcohol to ester
A
Carboxylic acid, conc H2SO4
Or acyl chloride
Or acid anhydride
