Organic Anki Cards

Question 1

Excess water added to ethanal. Why is reaction slower than other reaction?

Answer 1

C in C=O is less delta positive/ less e deficient
As CH3 attatched is electron donating or CH3 has inductive effect therefore higher Ea

Question 2

Why does cisplatin cause hair loss?

Answer 2

Prevents replication of healthy cells by bonding into healthy DNA leading to unwanted side effects.
Side effects can be minimised by giving in small doses

Question 3

How do zwitterions form?

Answer 3

When amino acid reaches isoelectric point when Ph has overall charge of zero.
Zwitterions= amphoteric

Question 4

2 properties of zwitterions

Answer 4

White solids with high mpts
Soluble in water

Question 5

Tertiary structure

Answer 5

Interaction between side groups influence shape
H bonds- OH in serine
Ionic bond- between NH3+ and COO- ie. Lysine and aspartic acid
Disulphide bonds- 2cysteine groups

Question 6

Hydrolysis of protein conditions

Answer 6

6moldm-3 HCL
110°
Reflux for 24hr

Question 7

Why dicarboxyliv acids can be distinguished from 2 diols by high resolution mass spec using electrospray ionisation?

Answer 7

Precise masses are different.

Question 8

Hard to find antibiotics specific to enzyme?

Answer 8

Active sites= chiral molecules therefore stereospecific therefore only one enantiomer will fit

Question 9

Why lysine leaves column after alanine

Answer 9

Lysine has double positive charge
And has greater attraction/ affinity to stationary phase