Organelles Flashcards
Centrosome
centrally located microtubule organizing center. Contains a pair of centrioles that separate to form spindle poles during mitosis.
Cytoskeleton
organizes the cell structure, shape and arrangement of subcellular organelles. Consists of 3 major components: microtubules, thin filaments (actin), and intermediate filaments.
Cytoplasm
everything inside the plasma membrane excluding the nucleus
Cytosol
fluid surrounding the organelles
Endoplasmic reticulum
Network of membranous tubules that extend from the nuclear envelope throughout the cell. Major site of protein and membrane lipid synthesis. Regions with ribosomes attached to the cytosolic surface are called rough ER and regions without are smooth ER
Endosomes
series of organelles that sort endocytosed materials sending them to lysosomes or back to the plasma membrane
Golgi apparatus
consists of a stack of flattened sacs that can be divided into 3 compartments; cis golgi network, medical golgi stacks, and trans golgi network. Proteins and lipids synthesized in the ER are delivered to the golgi stack where they’re modified, sorted , and packaged for secretion or delivery to lysosomes or the plasma membrane
Lysosomes
low pH organelle containing digestive enzymes that work best at low pH. responsible for digesting worn out or unwanted organelles as well as macromolecules and particles taken into the cell by endocytosis. The digestion products are typically re-used by the cell.
Mitochondria
powerhouse of the cel generating most of the ATP required by mammalian cells via fuel oxidation and oxidative phosphorylation. Contains two membranes separating the mitochondrial matrix from the cytosol. Inner membrane is extensively folded to form cristae containing the electron-transport chain and ATP synthase. Contains its own small circular DNA in the matrix compartment that encodes a handful of proteins.
Nucleus
typically the largest and most prominent organelle in the cell. Surrounded by a double membrane (nuclear envelope) containing nuclear pores that control passage of macromolecules into and out of the organelle. Contains DNA in the form of chromosomes, and is the site of DNA replication and transcription.
Nucleolus
substructure within the nucleus responsible for the transcription of processing of rRNAs and for assembly of ribosomal subunits.
Peroxisomes
small organelles containing enzymes involved in the oxidative reactions that break down lipids and destroy toxic molecules. Reactions produce toxic hydrogen peroxide which can be used in oxidative reactions or degraded.
Plasma membrance
Separates the cell interior from the exterior and acts as a permeability barrier. Composed of a lipid bilayer containing embedded proteins. Many of the lipids and proteins in the membrane contain covalently attached carbohydrate chains on the outer surface.
Proteasomes
cylindrical protein degradation machines located in the cytoplasm responsible for most of the protein turnover in the eukaryotic cell. Proteins destined for degradation are tagged with ubiquitin and fed into the cylinder where proteases chop them up into short peptides that are then released into the cytosol.
Riobosomes
particles composed of RNA and protein, responsible for catalyzing the synthesis of proteins