Organ Transplant

Question 1

________ is the only absolute contraindication to organ donation

Answer 1

A positive HIV status

Question 2

Transplant rejection can happen in 3 ways:

Answer 2

hyperacute, acute, and chronic rejection

Question 3

Hyperacute rejection is a ______that occurs within minutes of reestablishing blood supply to the organ

Answer 3

vascular thrombosis

Question 4

Cause of hyperacute rejection

Answer 4

preformed antibodies

Question 5

How to prevent hyperacute rejection

Answer 5

It is prevented by ABO matching and lymphocytotoxic crossmatch, and thus it is not seen clinically.

Question 6

__________ occurs after the first 5 days, and usually within the first 3 months

Answer 6

Acute rejection (most common)

Question 7

Thus, the first goal when liver function deteriorates posttransplant (rising g-glutamyltransferase [GGT], alkaline phosphatase, and bilirubin) is____________

Answer 7

to rule out biliary obstruction by U/S and vascular thrombosis by Doppler

Question 8

The first line of therapy for acute rejection is

_______

Answer 8

steroid boluses.

Question 9

If unsuccessful with steroids, ________have been used though their high toxicity is a problem. Newer anti-thymocyte serum is tolerated better

Answer 9

antilymphocyte agents (OKT3)

Question 10

__________ is seen years after the transplant, with gradual, insidious loss of organ
function. It is poorly understood and irreversible.

Answer 10

Chronic rejection