Organ Failure

Question 1

Drugs avoided in renal failure

Answer 1

Abx - tetracycline, nitrofurantoin
NSAIDs
Lithium
Metformin - risk of lactic acidosis

Question 2

Drugs which can accumulate in chronic kidney disease - need dose adjustment

Answer 2

Most Abx - penicillins, cephalosporins, vancomycin, gentamicin, streptomycin
Methotrexate
Digoxin, atenolol
Sulphonylureas
Furosemide
Opioids

Question 3

Drugs that worsen heart failure - avoid!

Answer 3

Thiazolidinediones e.g., pioglitazone - fluid retention
Verapamil
NSAIDs - low dose aspirin acceptable
Glucocorticoids
Class I anti arrhythmics e.g., flecainide