Oral Surgery & Oral Pathology Flashcards

(155 cards)

1
Q

What are the 2 main forms of Anti-resorptive medications?

How do they differ in:

  • Method of Action?
  • Method of Administration?
  • Half life?
A
  1. Bisphosphonates
  2. RANKL Inhibitors (Denosumab)

Both indicated for: Osteoporosis, Cancer or bone disorders (e.g. Pagets)

Method of Action:
Both inhibit bone resorption by inhibiting osteoclast activity
B = via osteoclast apoptosis
R = via inhibition of RANKL (normally stimulates osteoclast function)

Method of Administration:

  • *B** = Oral (often once a week) or IV (6 monthly or yearly)
  • *R** = Subcutaneous (6 monthly)

Half-life:

  • *B** = Longer half-life (~10 years) & binds to bone
  • *R** = Shorter half-life () & does NOT bind to bone
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2
Q

What are 5 functions of the maxillary antrum?

A
  1. Lighten the skull
  2. Moistens inhaled air
  3. Warms inhaled air
  4. Voice resonance
  5. Immunological function for upper respiratory tract
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3
Q

What is the definition of an abscess?

Its aetiology is bacterium, what are the 3 main routes of entry?

A

A pathological cavity filled with pus and lined by a pyogenic membrane.

Bacterial entry via:

  1. Apical foramen
  2. PDL
  3. Bloodstream (“Anchoresis”)
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4
Q

What are the following flap names?

A
  1. Envelope (One-sided)
  2. Triangular (Two-sided)
  3. Trapezium (Three-sided)
  4. Semi-lunar
  5. Y-Incision
  6. Pedicle
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5
Q

Aspirin:

  1. What is the MOA?
  2. How does its affect differ to other NSAIDs?
  3. What is our OS management for patients taking Aspirin?
A
  1. Anti-platelet, inhibits thromboxane A2 via COX-1 pathway inhibition
  2. Causes IRREVERSIBLE platelet changes (lasting platelet 7-10day lifespan)
  3. Nothing - Don’t interupt/alter medication. Can treat with cautionary measures (e.g. limiting area/earlier in week) & local haemostatic measures
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6
Q

How many times a day are each NOAC usually taken?

According to SDCEP Guidelines, what instructions should be given to the patient (pre/post-op)?

A

Rivaroxaban - ONCE

Apixaban - TWICE

Dabigatran - TWICE

Edoxaban - ONCE

Once a day?
Morning = Delay morning dose & take 4hr after haemostasis
Evening = Take evening dose as normal (as long as 4hr after haemostasis)

Twice a day? MISS morning dose & take evening dose as normal (as long as 4hr after haemostasis)

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7
Q

What is the management for a patient with Acute Osteomyelitis? (6)

A
  1. URGENT OM/OS referal
  2. Empirical antibiotics (broad-spec antibiotics, e.g. Benzylpenicillin, Clindamycin and Metronidazole)
    * N.B. Clindamycin has good bony penetration but risk of C. difficle → severe diarrhoae*
  3. Pus sample taken
  4. Specific target antibiotics
  5. Debridement
  6. Long-term antibiotics 2+ weeks (Out Patient Antimicrobial Therapy, OPAT)
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8
Q

SDCEP says INR within 72hr is acceptable if patient has stable INR history - specifically, what does this mean?

A

A patient who does not require weekly INR checks & hasnt had any INR readings above 4 in the last 2 months

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9
Q

The first stage of infection spread is Cellulitis, what is this and what would be observed?

(Think appearance & bacterium present)

A

Cellulitis = Infection spread to connective tissue → Soft tissue oedema

  • Redness
  • Shiny
  • Fluctuant (but this depends on amount of fluid present)
  • Non-suppurative
  • Usually streptococcus
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10
Q

What are the 5 aims of surgical extraction?

(THINK: Why raise flap? Why remove bone? Why suture?)

A
  1. Remove tooth (duh)
  2. Improve vision
  3. Create application point for elevation
  4. Minimise trauma
  5. Promote healing (via debridement and sutures)
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11
Q

In taking a good post-XLA pain history what should you ask?

What probing questions may you ask about symptoms?

A

SOCRATES (duh)

  • When did the pain start (how many days after XLA)?
  • Is it getting worse?
  • Is there any foul smell/taste? - Dry socket or pus
  • Is there limited mouth opening
  • Is there any swelling
  • Systemic features - Fever, temporature or malaise?
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12
Q

What are the 6 main stages involved in surgical tooth extraction?

A
  1. Plan access (flap design)
  2. Raise mucoperiosteal flap
  3. +/- Bone removal
  4. +/- Sectioning of tooth - Start at furcation and go to burs depth (avoid drilling through whole tooth, may cause lingual nerve damage - use space created for elevation_
  5. Debridement/Irrigation - Saline +/- haemostatic agent
  6. Wound closure with sutures
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13
Q

What are 5 signs of Mandibular fracture?

A

“Mandibles Open Now Tallulah Says”

  1. Mobility
  2. Occlusion change
  3. Numbness of lower lip (IAN)
  4. Trismus
  5. Sublingual haematoma (blood seen under tongue)
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14
Q

What is the definition of MRONJ?

Following this, what are the 4 diagnostic features that must be met?

A

MRONJ (Medication-Related Osteoonecrosis of the Jaw)

Severe adverse reaction to anti-resorptive or anti-angiogenic drugs → Exposed bone or bone that can be probed through an intra or extra-oral fistula in the maxillo-facial region which has persisted over 8 weeks in a patient with history of taking the above drugs and NO history of radiotherapy or obvious metastatic jaw disease.

Diagnostic Criteria:

  1. Currently or previously taking anti-resorptive or anti-angiogenic medication
  2. Exposed bone or bone that can be probed through intra or extra-oral fistula - persisting over 8 weeks
  3. No history of radiotherapy
  4. No obvious metastatic jaw disease
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15
Q

What are the gross characteristics of a benign oral lesion?

(e.g. size/shape) - 6

A
  • Encapsulated
  • Rounded
  • Small (smaller than malignancies)
  • Slowed growth
  • Rare ulceration or bleeding
  • Can produce hormones (e.g. in endocrine tissues)
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16
Q

What are 7 indications for removal of cysts or benign soft tissue lesions?

A
  1. Pain
  2. Infection
  3. Altered function
  4. Pressure on adjacent structures
  5. Weakening of adjacent structures
  6. Continuous growth
  7. Poor aesthetics
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17
Q

What are 4 radiographic signs that show close proximity of 3rd molar to ID nerve (/linked with ID nerve damage)?

A
  1. Interruption or Loss of white tramline (most common)
  2. Darkening of the root (“Banding”)
  3. Diversion of ID canal
  4. Narrowing of canal
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18
Q

What is the difference between primary & secondary haemostasis?

How can both be adversely affected?

A

PRIMARY = Platelet aggregation

  1. Failure in Platelet production (“Thrombocytopenia)
    * Bone marrow failure, Congenital disorders or Megakaryocyte depression (e.g. via chemotherapy, infections or drugs - alcohol/heparin/thiazide diuretics)*
  2. Failure in Platelet function
    * Von Willebrand’s Disease (reduced/defective vWF) or drugs - NSAIDs (via COX-1)/ Clopidogrel (via ADP)*
  3. Failure in Platelet survival
    * Autoimmune, HIV-associated, Malaria, Lymphocytic leukaemia or Drugs - Aspirin/Cytotoxics/Valproate*

SECONDARY = Coagulation pathway into fibrin clot

  1. CONGENITAL (Haemophilia A/B or vWD)
  2. ACQUIRED (Anti-coagulant medications, Vit K deficiency, Liver disease or Large volume blood transfusions)
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19
Q

What are the different drugs that are implicated in MRONJ (4)?

How can they be placed into 2 main catagories?

A
  • *1) Anti-resorptive**
  • Inhibit bone resorption (impaired osteoclast function)*
  • Bisphosphonates
    E.g. Zoledronate (IV) or Alendronate (Oral)
  • RANK-L inhibitor
    E.g. Denosumab (subcutaneous)
  • *2) Anti-angiogenic**
  • Inhibit blood vessel formation (angiogenesis)*
  • VEGF Inhibitor
    E.g. Bevacizumab (IV)
  • Tyrosine Kinase Inhibitor
    E.g. Sunitinib (Oral)
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20
Q

What is Osteomyelitis?

What are the 5 risk factors?

A

Osteomyelitis = Inflammation of the medullary bone due to mixed bacterial Infection

  1. Radiotherapy
  2. Trauma
  3. Bisphosphonates
  4. Bone diseases (e.g. Pagets or Osteoporosis)
  5. Immunodeficiency (including malnutrition, systemic corticostroids , DM & age extremeties)
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21
Q

What is a “Guardsman’s Fracture”?

A

Fracture of the right and left mandibular condyle

Also presents with chin laceration from impact

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22
Q

What are some signs & symptoms of MRONJ?

A

May be ASYMPTOMATIC (MRONJ Stage 1) - AAOMS (2014)

Signs:

  • Exposed, necrotic bone
  • Gingival swelling
  • Secondary Infection (+/- suppuration)
  • Pain (persistent)
  • Absent or delayed healing
  • Pathological #

Symptoms:

  • Gingival tenderness
  • Halitosis
  • Parasethesia
  • Pathological #
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23
Q

How might clinical features of an abscess differ if the origin was periapical vs. periodontal?

A
  • Periapical associated with non-vital tooth
  • Periapical = history of trauma and/or caries
  • Periapical = not well localised pain but TIQ painful to touch
  • Periodontal = MOBILE tooth which is TTP
  • Periodontal = Vital (or non)
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24
Q

What is the difference between acute and chronic periodontitis?

(Consider symptoms, clinical findings and radiographs)

A
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25
Name 8 conditions that might affect the maxillary antrum?
1. Cleft palate 2. Acute/Chronic Sinusitis 3. Cyst 4. Tumour 5. Paget's Disease 6. Fibrous Dysplasia 7. Iatrogenic - Oral Antrum Communication/Fisulae or Antral fracture
26
What are the 3 main methods of infection spread? Which is the most common?
1. Direct (most common) 2. Lymophatics 3. Blood Infection spread follows pathway of LEAST resistance (E.g. Periodontal abscess = Through periodontal pocket Periapical abscess = Through thinnest cortical plate)
27
What are some _systemic_ haemostatic measures which may be used in hospital (under haematologist guidance) if a patient fails to stop bleeding?
1. Transexamic acid (anti-fibrinolytic) 2. Desmopressin (vasopressin analogue - stimulates release of CF8, vWF & tPA) 3. Fresh frozen plasma (with Clotting Factors) 4. Platelet transfusion 5. Antidotes: Vitamin K (Warfarin) or Andexanet alfa (Xa NOACs)
28
1. What is the normal lifespan of a platelet? 2. What cell are they produced from? 3. What is the normal level of platelets? 4. What level must platelets be above for (invasive) dental treatment to be carried out? (Guidelines?)
1. 7-10 days 2. Megakaryocytes (& activated by surface contact with damaged epithelium) 3. 150-400 x109/L 4. 50 x109/L (British Society for Standards in Haematology, 2013)
29
What are the 6 main principles of flap design in surgical extraction?
1. Maintain blood supply (BROADER at BASE) 2. Avoid vital structures 3. Suture over bone 4. Preserve papillae 5. Maintain ability to extend 6. Maintain ability to close site
30
When draining an abscess in the submandibular space, what are 4 structures you should watch out for? How can these be avoided (where should you put your incision)?
1. Facial artery 2. Facial vein 3. Facial nerve 4. Hypoglossal Horizontal incision (parellel to lower border of mandible) made 2 fingers width below lower border of mandible
31
How would you manage a patient who's about to start taking anti-resorptive or anti-angiogenic medication?
* Pt education on MRONJ risk, dont discourage drug use * Low incidence (0.01-0.1% in Osteoporosis & ~1% Cancer pts)* * Thorough dental assessment: - XLA poor prognosis unrestorable teeth - OHI, Smoking/Alcohol cessation & Stabilisation - Adjust/replace ill-fitting dentures * **If XLA, allow complete healing before initiation of therapy, ideally ~4weeks. (UKCB, 2019)*** * High Risk prevention: - OHI, FV, Duraphat, F m/w, Smoking cessation & reduced recall
32
What are 8 indications of removal of 3rd molars? According to what guidelines?
NICE - Guidance on Extraction of Wisdom Teeth 1. Unrestorable caries 2. Untreatable pulpal/periapical pathology 3. Pericoronitis (1 severe or multiple episodes) 4. Abscess / Cellulitis / Osteomyelitis 5. Cyst / Tumour (disease of tooth follicle) 6. Internal or External resorption (of TIQ or adj. tooth) 7. Tooth in line of jaw surgery 8. Fracture of tooth
33
What are 5 virulence factors for bacterium (e.g. in abscess formation)?
1. Number of bacterium 2. Invasion mechanisms 3. Evasion of host defence (e.g. capsules and proteases) 4. Toxins and Enzymes (e.g. endotoxin, collagenase, hyaluronidase and fibrinolysin) 5. Time & Hose response (acute/chronic)
34
According to SDCEP, what places a pt at "high risk" of MRONJ? (4)
1. Treatment need - Cancer pt 2. Previous MRONJ 3. Bisphosphonate use over 5 years 4. Concurrent Bisphosphonate/Denosumab use with Systemic Glucocortocoids N.B. Denosumab use over 9 months ago = No risk Denosumab use within 9 months (no SG use) = Low risk
35
What are the 4 management goals for a patient with MRONJ?
1. Prioritise oncology treatment (delay tx) 2. Maintain QoL (extirpate \> XLA) 3. Control pain + infection (analgesics and antimicrobials) 4. Prevent extension or formation of new osteonecrotic lesion
36
Describe how the position of a MAXILLARY POSTERIOR infection in relation to the BUCCINATOR muscle would affect the direction of spread?
ABOVE → Buccal Space BELOW → Buccal Sulcus
37
For MRONJ, what are the vague dates/duration of treatment that puts a pt at higher risk if having: 1. IV bisphosphonates? 2. Oral bisphosphonates?
IV = 3+ infusions or 1 year Oral = 4+ YEARS
38
What are 12 intra/peri-operative complications during extraction?
1. Needle stick injury 2. Wrong tooth XLA 3. Damage to adjacent teeth or soft tissues 4. OAC or displacement of root(s) into sinus 5. Fractured tooth/apex (retained root) 6. Swallowing/Inhalation of tooth fragment 7. Fractured mandible 8. Fractured tuberosity 9. Fractured alveolar bone 10. Haemorrhage 11. Lip burn (from drill)
39
Describe how the position of a MANDIBULAR ANTERIOR infection in relation to the MENTALIS MUSCLE would affect direction of spread?
ABOVE Mentalis → Labial sulcus BELOW Mentalis → Submental (Causes swellings in these areas)
40
What are the clinical features you would observe/smell in a patient with Dry Socket? (4) What would be the presenting pain history?
1. _Empty_ socket with visible _exposed bone_ 2. Erythematous and tender surrounding gingivae 3. Throbbing pain 4. Foul smelling odour PAIN: Pain starting 2-3 days post-extraction and getting progressively worse
41
What is meant by "empirical" antibiotics in treatment of dental abscesses? Give examples.
Antibiotics prescribed first "Empirical" = Observation alone E.g. * Penicillins (Penicillin V or Amoxycillin) * Nitroimidazoles (Metronidazole) * Pt with penicillin allergies = Erythromycin, Clindamycin or Tetracyclin Pus sample obtained and sent to labs. More specific antibiotic can then be prescribed to target bacterium present.
42
A patient comes in with an abscess/spreading infection, in what cases would you refer them to hospital? (5)
* Obstructed airway (e.g. Ludwig's Angina) * Rapidly spreading infection * Systemic signs: Pyrexic, raised BP, raised WBCs, malaise and toxic appearance * Immunocompromised/Diabetic pt * Severe trismus
43
Describe how the position of a MANDIBULAR POSTERIOR infection in relation to: 1. MYLOHYOID 2. BUCCINATOR would affect direction of spread?
**1) MYLOHYOID** ABOVE → Sublingual BELOW → Submandibular *Mylohyoid runs low anteriorly + higher posteriorly; so posterior infections more likely to have submandibular spread* **2) BUCCINATOR** ABOVE → Buccal sulcus BELOW → Buccal space *This is VICE VERSA for Maxillary posterior teeth!*
44
What are 8 post-operative complications following tooth extraction?
1. Pain / Bruising / Swelling 2. Bleeding - Reactionary (loss of clot in first 48 hours) or Secondary (infection or bleeding disorder) 3. Infection (+ spread) 4. Dry socket 5. Osteomyelitis 6. Nerve damage 7. Haematoma 8. TMJ injury
45
What is a coronectomy? What happens? When may it be indicated or contra-indicated?
"Intentional Partial Odontectomy" * Crown sectioned at CEJ * Decorination of crown * Drill 2-4mm below crestal bone (root surface lies here and we want no enamel left in situ) Indication: 3rd molar removal where close ID canal proximity Contra-indication: Caries or Mobile roots
46
For patients at increased bleeding risk, what pre-op & peri-op procedures can be adhered to?
_Pre-op:_ * Thorough medical history (are medications for limited time or lifetime? may be able to delay tx) * Ask about patients previous extraction/bleeding experiences * Plan treatment for earlier in day & week _Peri-op:_ * Consider limiting initial treatment area & assessing bleeding * Make as atraumatic as possible
47
What dental measures should be put in place for patients after undergoing cancer therapy?
# * Enhanced prevention & reduced recall * Awareness of increased risk of: Xerostomia, Caries, Perio, Infections, Trismus, ORN/MRONJ or Osteomyelitis * Choose flouride-releasing restorations where possible * Avoid XLA if possible * Avoid denture wear if possible (if not, make atraumatic, advise good hygiene & can incorporate Nystatin into soft lining material Awareness of neutropenic/thrombocytopenic risk - Avoid treatment & liase with oncologist if - Platelets below 60,000/mm3 - Neutrophils below 2000/mm3
48
IMP EXAM Q ## Footnote What are 10 risk factors for Dry Socket?
1. Traumatic extraction (e.g. surgical) 2. Mandibular extraction (less vascular) 3. Previous dry socket experience 4. Smoker 5. Female 6. Oral Contraceptive Pill 7. Poor OH 8. Periodontal disease 9. Excessive vasoconstricter (e.g. LA → reduced blood supply) 10. Bone disorders (e.g. Pagets)
49
If a patient is deemed to require/benefit from antibiotic prophylaxis for IE risk, which (2) antibiotics could be prescribed? What instructions (pre-op & post-op) are given to the patient?
1. Amoxicillin (3g) Oral Powder Sachet (1hr pre-op) 2. Clindamycin (2x 300mg) Oral Capsules (1hr pre-op) *Alternatives can be given IV or Oral Suspension if pt cannot swallow* _Pre-op:_ ​ Pt to bring ABx & take in the practice 1hr pre-op (can be taken at home if no previous adverse reactions to prophylaxis) _Post-op:_ Warn of risk of c. difficile (seek medical attention if severe diarrhoea)
50
What is the OS managment for patients taking Warfarin?
DO NOT STOP TAKING WARFARIN * Assess patients INR ideally within 24hr of surgery (at least 72hr if patient has stable INR range 2.5-3.5 +/-0.5) * If patient's INR is below 4; treat without interupting * Consider: Limiting/staging treatment area, early appt day/week & local measures (5) * If patient's INR is above 4; delay treatment or refer to secondary care if urgent
51
What is the main flap design for removal of third molars? (2)
Envelope (1-sided) or Triangular (2-sided)
52
What are the 3 main special investigations done when suspected Osteomyelitis? (What would you see on the radiograph - 4/5)
**1) Radiograph (PA/Sectional OPG)** * "Moth-eaten" bone appearance * Loss of trabecular pattern * "Rarefying osteitis" - Poorly defined radiolucency * CHRONIC ⇒ Periosteal reaction (new bone formed) & Irregular radiopacities (bony sequestra) **2) Pus sample** (& used to target antibiotic therapy) **3) Blood Tests -** Raised WBCs and CRP FGDP (2020) - "+/- CBCT or MRI to rule out bone tumours"
53
What is the most common site for OM & why? What are 5 clinical features in Osteomyelitis? Which are more likely in Chronic OM?
Mandible = Most common site (less vascular) ACUTE: "Male patient with multiple dental infections" 1. Throbbing pain (more rapid onset & severe in Acute OM) 2. Swelling (soft & becomes more hard due new bone formation) 3. Paraesthesia of lip/chin (compression of CN Viii) 4. Systemic signs: Lymphadenopathy, Pyrexia or Malaise 5. CHRONIC ⇒ Localised necrotic bone +/- suppuration or bony sequestra
54
What are the 3 stages of abscess infection spread?
STAGE 1: **CELLULITIS** *Oedema as infection spreads to connective tissue* * *Red & shiny* * *Fluctuant (but varied firmness dependent on amount of fluid present* * *Often non-suppurative (except at source)* * *Often Streptococci seen* STAGE 2: **SUPPURATIVE ("PUS-PRODUCING")** *Pus produced from _centre_ of lesion Dependent on: Gravity, Muscle activity and Pressure* STAGE 3: **GANGRENE**
55
What is the management of Dry Socket?
1. Reassure (right tooth taken out, non-serious and will resolve) 2. Irrigate with saline (or CHX) under LA * SDCEP (2013) Management of acute dental problems - "No evidence in favour of CHX use, not recommended"* 3. Place Alvogyl (*LA, Iodine & Eugenol)* or ZOE dressing 4. Pt Advice - Good OH, avoid smoking and adequate analgesia 5. Review appt (after few days and can be done over the phone)
56
What are the 4 NOACs? What clotting factor do they affect & how can their anti-coagulant effect be measured? How often are they taken? What is their onset (all same) & half life
1. RIVAROXABAN (OD) - Factor Xa (meausured by PT) & 5-13hr half life 2. APIXABAN (BD) - Factor Xa (measured by anti-Xa assay) & ~12hr half life 3. DABIGATRAN (BD) - Factor II (measured by aPTT) & ~13hr half life 4. EDOXABAN (OD) - Factor Xa All have short onset (2-4hr)
57
What are the advantages (3) and disadvantages (6) of Enucleation?
ADVANTAGES: 1. Complete cyst lining obtained for histology 2. Cavity closed - Reduced infection risk 3. Little aftercare needed DISADVANTAGES: 1. Cavity clot may become infected 2. Haemorrhage risk 3. Large cyst removal → Weakened jaw 4. Potential damage to adjacent structures or apicies of vital teeth 5. Primary closure prevents visual inspection of cyst cavity 6. Incomplete removal → Recurrence
58
What differences exist between Acute and Chronic Osteomyelitis for: 1. prevalence? 2. pain/clinical presentation? 3. management?
CHRONIC osteomyelitis is more common! _Clinical presentation:_ * Acute = Dull, throbbing pain Chronic = LESS painful and LONGER LASTING * Chronic = Localised necrotic bone +/- suppuration & sequestra _Management:_ * OS/OM referral (urgent for acute) * Empirical antibiotics, take pus swap and target antibiotics * Debridement * Long term (2+ weeks ) out patient antibiotics (OPAT) Chronic [Above] and: Debridement, Corticotomy +/- Antibiotic bead placement (e.g. Gentamicin)
59
What are 6 blood tests that may be done in hospital if a patient fails to stop bleeding?
1. Full Blood Count - platelets? anaemia? 2. Prothrombin time (PT) - extrinsic pathway 3. Activated partial prothrombin time (aPPT) - intrinsic pathway 4. Specific clotting factor assays 5. Liver & kidney function tests 6. INR (for patients on Warfarin)
60
What are 3 considerations for removal of 3rd molars which are NOT covered in NICE guidelines?
1. Distal caries in 7's (mesially impacted 8's) 2. GA - If pt undergoing GA and 8's likely to later become symptomatic 3. Non-functional 8's → Over-eruption and trauma
61
What are 7 causes of a dental abscess ? (Think about routes of entry)
1. Caries 2. Non-vital tooth 3. Trauma 4. Deep periodontal pockets (via lateral canals) 5. Blood stream ("Anchoresis") 6. Extension of periapical infection from adjacent teeth
62
What preventative measures should be put in place for a patient about to undergo cancer therapy? What guidelines are useful for this?
RCS/BSDOH - "The Oral Management of Oncology Patients Requiring Radiotherapy, Chemotherapy and/or Bone Marrow Transplantation" * Full dental check: Stabilisation, Restorations & XLA poor prognosis teeth (ideally 3wk before cancer therapy commences, at least 10 days) * Enhanced provention (DBOH) & reduced recall * Educate pt on side effects of radio/chemo therapy (mucositis, xerostomia, increased infection & caries risk) * Denture OH (ideally dont wear, if worn ensure no trauma, cleaned & removed at night) * Dietary advice *alongside dietician* (pt may be prescribed a high calorific diet, ensure dietary advice does not conflict with this - can advise use of straws/water or mw between food intake)
63
What is meant by a "POLO" 3rd molar? What might be a good treatment option for its removal?
Mandibular 3rd molar that perforates ID nerve Ideally leave (asymptomatic) but coronectomy if must be removed
64
Rarely, dental infections can spread to fascial planes - what are 5 potential areas of spread? (PIMP C)
1. Prevertebral fascia 2. Investing layer of deep cervical fascia 3. Mediastinum → Pericarditis 4. Pretracheal fascia 5. Carotid sheath
65
What is infective endocarditis? What patients are at increased risk & of those who belong to a sub-catagory group who should be under special consideration for antibiotic prophylaxis?
IE = Infection of endocardium (heart lining), often valves Rare! 1 in 10,000 _Increased risk:_ * Acquired valvular heart disease with stenosis or regurgitation * Hypertrophic Cardiomyopathy * **_Previous infective endocarditis_** * **_Prosthetic heart valve_** * **_Congenital heart defect - Cyanotic CHD or CHD with prosthetic valve replacement_** ***_Bold & underlined = special consideration group_*** *Liase with patients cardiologist regarding need/type of ABx prophylaxis*
66
What are the bacterial/immunological (3) and anatomical (3) factors that affect the spread of infection?
_Bacterial/Immunological:_ * Number + virulence of bacterium * Host defence (e.g. immunocompromised) * Failure to drain pus (increased infection) _Anatomical:_ * Source of infection * Point of pus drainage through bone * Natural barriers to spread (e.g. mucous membranes)
67
Osteoradionecrosis has similar features to Chronic Osteomyelitis (e.g. localised sclerotic bone, extra/intra oral fistula)... except...? (2)
1. Healing is slower or non-existent 2. NO periosteal reaction (no new bone growth) → Higher pathological fracture risk (& less R/O seen radiographically)
68
What is the safest antibiotic to take alongisde Warfarin? Which 3 should be avoided?
AVOID: Metronidazole, Erythromycin & Clarithromycin Best = Clindamycin (Can consider Amoxicillin, but monitor INR 24hr after starting antibiotic - SDCEP)
69
What are the 1. Local (5) 2. Systemic (6) risk factors for impaired socket healing post-XLA?
**1) LOCAL** * Inflammation * Foreign body presence (including dressings!) * Bony fragment * Remaining tooth tissue * Radiation exposure **2) SYSTEMIC** * Medications (Bisphosphonates, Corticosteroids, OCP and Immunosuppressants) * Smoking * Diabetes * Malignancy * Nutritional deficiencies * Vascular diseases
70
What staging can be used for ORN (Osteoradionecrosis)? (HINT: 3 stages)
**"Notani" Staging:** STAGE 1 = ORN confined to alveolar bone STAGE 2 = ORN limited to alveolar bone and/or mandible (above level of mandibular canal) STAGE 3 = ORN extends to mandible UNDER level of mandibular canal and/or skin fistula and/or pathological fracture
71
How can you get valid conset from the patient before extraction? What should you warn them of (general risks)? What is meant by 2-stage consent?
Valid consent = Voluntary, Competent patient & Informed (of benefits vs. risks and all tx options in easy to understand terminology) _Risks:_ * Post-op bleeding, bruising, swelling and pain * Infection * Damage to adjacent teeth * Trismus * Surgical +/- sutures * Upper = OAC and Fractured maxillary tuberosity * Lower = Dry socket and Paraesthesia of lip/chin/tongue _2-Stage Consent:_ 1st = Information given, discussed and consent signed 2nd = Consent reconfirmed before treatment (copy of consent form to be given to patient)
72
What is Dry Socket? * Alternative name * Aetiology
(Also known as "Localised Alveolar Osteitis") _Aetiology:_ INFLAMMATION due to **absence of blood clot** * Failure to form * Dislodged/lost * Excessive fibrinolytic activity Bacterial colonisation → Further clot lysis Regional inflammation prevents infection spread beyond socket
73
What are the 4 main methods of surgical cyst removal?
1. **Enucleation** 2. **Marsupialisation** 3. Excision (Ellipse-shaped incision and excisional biopsy) 4. Curettage (raising flap and Mitchell trimmer curettage)
74
**_WARFARIN_** 1. What is the MOA? 2. What are some indications for its use? (6) 3. What are some side effects of its use? (5) 4. How is it monitored? What is the normal range? 5. What is the overdose antidote?
1. Anti-coagulant: Vitamin K antagnoist - Inhibits Vit K-dependent clotting factors **(2,7,9&10)** 2. Treatment or Prophylaxis for: Stroke, Atrial Fibrillation, DVT, Pulmonary Embolism, Coronary Heart Disease or Prosthetic Valve/Stent placement 3. Rashes, alopecia, bruising, liver disorders/jaundice or GI upset 4. INR (International Normalised Ratio) Normal range: 2.5-3.5 (+/-0.5) 5. Vitamin K (IV)
75
What are some acute (ST) & chronic (LT) oral side effects of radiotherapy?
ACUTE * Mucositits ACUTE & CHRONIC * Xerostomia * Dysguseia (loss or change in taste) * Dysphagia * Increased bleeding risk (thrombocytopenia) * Increased infection risk (neutropenia) CHRONIC * Radiation caries * Increased risk of ORN or Osteomyelitis
76
What is the definition of "Osteoradionecrosis"?
A _non-healing_ region of _devitalised_ bone in a _previously radiated_ field, which persists for a _minimum of 3 months_ in the absence of a reoccuring malignancy. Radiation ⇒ Reduced vascularity & Osteocyte damage Increased radiation dose (above 60Gy) = Increased risk
77
A patient at high risk MRONJ has come in for an extraction, what is your management?
* Consider alternatives for XLA (e.g. extirpate) * If XLA remains most appropriate option: - Education patient on risks & benefitd (valid consent) - Consider referral to secondary care (e.g. high risk cancer pt or medically complex) - XLA *can* be carried out in primary care _Extraction:_ * Avoid surgical * XLA one sextant at a time and monitor healing * CHX mouthwash before AND after XLA (2 wks) * DO NOT prescribe antibiotics * Safety net patient (contact if signs/symptoms) * Review healing at 8 weeks
78
If a dento-alveolar abscess is left untreated, what will happen? What are the 3 general routes of biological pus drainage?
Untreated → Abscess enlargement and spontaneous pus drainage (through pathway of least resistance) 1. Through sinus tract, into oral cavity or facial skin 2. Through root canal or PDL 3. Through cancellous bone and cortex perforation Spontaneous drainage incomplete and does not address cause → Chronic/Reoccuring Abscess
79
In cryotherapy, what happens at: 1. -20°C? 2. -50°C?
1. Partial destruction 2. COMPLETE destruction
80
According to NICE/SDCEP guidance on ABx prophylaxis for Infective Endocarditis, what counts as an "invasive dental procedure"?
* Sub-gingival scaling/restorations/matrix placement * 6PPC * PMC/SSCs * Abscess drainage * Endodontics (before apical stop established) * Extractions * MOS * Implants N.B. Removal of sutures, trauma to lips/mucosa & exfoliation of primary teeth all NOT included
81
If a patient comes in with uncontrollable post-op bleeding, what should your management be?
* Clean pt & reassure (looks worse as blood mixes with saliva) * Assess site under good lighting & suction to determine origin * Check underlying causes: MH/FH, past XLA experience, nature of surgery & take patients BP/pulse * Local haemostatic measures (8): Pressure gauze, LA (vasoconstrictor), Pack (surgicel), Suture, Tranexamic acid m/w, Diathermy, Bone wax or Suck-down splint * Sit patient up and wait 15mins for bleeding to cease - If bleeding persists send pt to hospital for further investigations & treatment * POIG - Paracetamol (avoid NSAIDs/alcohol/smoking) & emergency out of hours contact
82
What is the difference between Enucleation and Marsupialisation?
**Enucleation =** Complete removal of lesion with in-tact lining (e.g. smaller cysts) **Marsupialisation =** 2 stage process 1. Marsupialisation - Incision (create largest possible window) and suture cyst lining to mucosal wall 2. Cyst decompression - Return once regressed in size and remove (e.g. larger cyst or close to vital structures )
83
What are the 2 main groups of medications causing increased bleeding in patients? (Give some examples)
1. Anti-coagulants Warfarin, Heparin, NOACs (Rivaroxaban, Apixaban, Dabigatran & Edoxaban) 2. Anti-platelets NSAIDs (Aspirin), Clopidogrel & Dipyridamole
84
Low Molecular Weight Heparin: 1. What is the MOA? 2. What is the administration? 3. What are 3 indications for use? 4. What should our OS management be?
1. Anti-coagulant (anti-thrombin) 2. Sub-cutaneous injection 3. Pregnancy (needing anti-coagulation), Thrombosis in cancer pt or Kidney Dialysis 4. Liase with medical professional & delay treatment if taken for limited time
85
What special investigations do you need for Dry Socket?
NONE - Clinical history and observation enough for diagnosis No radiographs needed - if pt presents again in pain take radiograph (LCPA) to investigate alternative diagnoses.
86
What are 4 indications of CBCT in dentistry? Why is it not routinely used?
1. Trauma 2. TMJD 3. Large bony lesions (e.g. cysts) where soft tissue doesnt need to be visualised (would use US/MRI) 4. 3rd molar surgery - Where conventional OPG radiograph not sufficient to show relationship to ID nerve Not routinely used as x10 more radiation vs. OPG
87
How might your OS assessment/management change for a patient with: 1. Acute DVT? 2. Coronary Stents? 3. Prosthetic Heart Valves?
1. May be taking higher NOAC dose in first 1-3weeks of treatment, if possible delay until standard dose started 2. Increased risk of thrombolytic events, do NOT alter medication unless under written guidance from their cardiologist. Often on dual anti-platelet therapy for 12months, followed by mono AP therapy for life 3. ABOVE & considered increased risk of Infective Endocarditis - Assess need for antibiotic prophylaxis with cardiologist
88
What is Ludwig's Angina? How does the patient present? How is it treated?
_Bilateral_ infection of the Sublingual, Submental AND Submandibular space _Presentation:_ * Fever (38.5°C) * Raised floor of mouth +/- deviated uvula * Difficulty swallowing, speaking or breathing (Dysphagia, Dysarthria or Dyspnoea) * May have had recent 3rd molar removal _Treatment:_ MEDICAL EMERGENCY - URGENT referral to A&E * Drainage * IV antibiotics * +/- Tracheostomy (airway management)
89
What are the local (6) and systemic (3) signs of an Acute Periapical Abscess? Will you see radiographical changes?
_LOCAL_ 1. Pain (often poorly localised but TIQ may be painful and _mobile_ if follows pericapical periodontitis) 2. Swelling 3. Redness 4. Heat 5. Trismus (loss of function) 6. Lymphadenopathy _SYSTEMIC:_ * Fever * Elevated pulse * Elevated WBC, Serum Proteins (e.g. CRP) and ESR Radiographical signs vary - May be too soon to see changes (acute inflammation would take a few days to resorb bone)
90
What is the antidote for: 1. Warfarin overdose? 2. NOAC (Rivaroxaban, Apixaban & Edoxaban) overdose?
1. Vitamin K 2. Andexanet alfa (very recent!)
91
Is the bacterium within an abscess: Mono-microbial or Polymicrobial? Endogenous or Exogenous? What bacteria are most often present?
Poly-microbial - Work syngeristiclly (together) Endogenous Bacteria present: * Obligate/Strict Anaerobes (most common) - *Fusobacterium, Prevotella, Porphymonas (esp. P. gingivalis)* * ​Facultative Anaerobes - *Streptococci*
92
What 4 signs might you see in a patient with a Zygomatic fracture?
1. Flattening + numbness of cheekbone 2. "Step deformity" on A-P palpation behind pt 3. Eyes - Diplopia, Restricted eye movement + Subconjunctival haemorrhage 4. Limited mandible opening (temporalis often affected)
93
What are 3 *_alternative_* techniques for cyst/benign lesion removal?
1. Laser 2. Diathermy (current) 3. Cryotherapy (cold liquid nitrogen at -196ºC)
94
What are 5 special tests you might want to take on a patient with a suspected dental abscess?
1. Radiographs (incl. CT and US) 2. Temperature 3. FBC - CRP 4. Pulse and BP 5. Blood glucose (poorly controlled diabetic = increased infection risk)
95
What are the EIGHT (?!) potential pathways of Mandibular infection spread?
1. Submental 2. Sublingual 3. Submandibular 4. Submasseteric 5. Buccal 6. Lateral Pharngeal 7. Peritonsillar 8. Pterygomandibular
96
What should you consider/do: 1. BEFORE 2. DURING 3. AFTER draining pus from an abscess?
1. BEFORE = Consider anatomical sites to avoid (e.g. Greater Palatine Artery in Palate and Facial artery/vein/nerve + Hypoglossal nerve in Submandibular space) 2. Breakdown/disturb locules in cavity with finger or sinus forceps 3. Keep drainage site open to allow further drainage
97
What are 3 indications for "special consideration" regarding antibiotic prophylaxis for Infective Endocarditis risk? What are the next measures for these patients?
1. Previous IE 2. Prosthetic valve replacement 3. Congenital Heart Disease - Cyanotic or involving prosthetic replacements Contact patient's cardiologist regarding heightened IE risk to assess need for ABx prophylaxis
98
What are the different management options for pericoronitis? (Can catagorise in 3 main groups)
1. Symptoms: Analgesia, 0.2% CHX Mouthwash and Debridement under Operculum (with LA) 2. Adjacent tooth: Extract or Smooth cusps if causing trauma 3. TIQ: Extract
99
What are the 4 potential pathways of MAXILLARY infection spread?
1. Canine 2. Buccal 3. Palatal 4. Lateral Pharyngeal (N.B. Buccal + Lateral Pharyngeal also in Mandibular spread)
100
What are the post-operative instructions for a patient after extraction? (7)
* LA wears off in few hours - Will get pain, take prophylactic pain relief * Soft diet (avoid hot foods esp with LA) * Avoid spitting/rinsing for first 24 hours * After, salt water rinses * Bite on gauze if bleeding/oozing * If serious bleeding & pain (lasting more than few days) - A&E or contact emergency number given * NO SMOKING
101
According to NICE/SDCEP guidance, what is the "routine management" of a patient who might be at higher risk of IE but does NOT require ABx prophylaxis?
* Explain IE (rare infection of heart lining, 1:10,000) * Dental procedures no longer believed to be main cause, invasive dental tx can increase risk but can also be caused by everyday brushing/flossing/chewing (good OH imperitive) * Explain risks & benefits of antibiotic prophylaxis (why not routinely used) * Prevention of IE: Good OH, regular recall & avoid non-medical risk factors (piercings/tattoos) * Educate patient on IE symptoms to seek treatment for (fever, malaise, weight loss, breathlessness or muscle/joint pain) * Ensure any dental infections are promply investigated & treated
102
What should be considered when offering ABx prophylaxis for Infective Endocarditis risk? (5)
* Cardiologist opinion * Patient consent * Medical History: Current medications & Allergies * Previous prescriptions (pt can take the same ABx for repeat invasive procedures over a short period of time BUT if taken ABx course within 6wks ago for infection, should consider different ABx class) * Ability to swallow
103
What are 3 signs in a patient with an orbital fracture?
1. **Enophthalmos** (sinking of eye into sockey 2. Diplopia 3. Restricted eye movement 4. Subconjunctival haemorrhage ("Hanging drop" sign seen radiographically)
104
What is the difference between: 1. PRIMARY haemostasis? 2. REACTIONARY haemostasis? 3. SECONDARY haemostasis? (think: when? why? how is it managed?)
1. **PRIMARY HAEMOSTASIS** During & immediately post-op Due to ST/vessel trauma, inflammation or infection Often controlled with local haemostatic measures 2. **REACTIONARY HAEMOSTASIS** Up to 24hr post-op Vasoconstrictor wearing off, loss of blood clot, anti-coagulant/platelet medication or underlying bleeding disorders Local haemostatic measures & may require systemic intervention 3. **SECONDARY HAEMOSTASIS** 7-10 DAYS post-op Mainly due to INFECTION Local haemostatic measures & ABx to manage infection
105
**_WARFARIN INTERACTIONS_** 1. What medications potentiate its anti-coagulation effect? 2. What medications antagonise its anti-coagulation effect?
POTENTIATE: * Metronidazole * Azole antifungals (e.g. Miconazole/Fluconazole) * Omeprazole * NSAIDs * Erythromycin/ Clarithromycin * Glucagon * _Acute_ alcohol intake ANTAGONISE: * Carbamazepine * Barbiturates * Rifampicin * St Johns Wort * Phenytoin * _Chronic_ alcohol intake
106
What are 3 indications (conditions) for use of Bisphonates?
1. Osteoporosis 2. Paget's Disease 3. Cancers - Multiple myeloma or Metastatic Bone Cancer
107
What anatomical **muscle(s)** affect the spread of infection for: 1. Mandibular incisors? 2. Mandibular pre-molars? 3. Mandibular molars? 4. Maxillary canines? 5. Maxillary molars?
1. Mentalis 2. Mylohyoid 3. Mylohyoid (lingual) AND Buccinator (buccal) 4. Strap muscles 5. Buccinator (and Antrum/Maxillary sinus)
108
**AAOMS (2014) Position Paper:** What is the staging of MRONJ & associated treatment? (0-3)
**_STAGE 0_** No visible exposed necrotic bone. Non-specific symptoms or clinical & radiological features *TREATMENT: - Symptomatic management (Analgesia & ABx) - Consider other differentials (e.g. Osteomyelitis or F-O Dysplasia) - Close review* **_STAGE 1_** Exposed necrotic bone (or probable through I/O fistulae) Asymptomatic. No signs of infection. *TREATMENT: - CHX (0.12%) mouthwash - Pt education & 3-monthly review* **_STAGE 2_** Exposed necrotic bone (or probable through I/O fistulae) Symptomatic. Signs of Infection. *TREATMENT: - CHX (0.12%) mouthwash - Symptomatic management (Analgesia & ABx\*)* - *Debridement* **_STAGE 3_** [As Above] & one or more of the following: - Exposed necrotic bone extending beyond alveolar bone - Extra-oral fisulae - Pathological # - OAC/ONC - Parasthesia *TREATMENT: [As Above] & Resectioning (+/- immediate plate or obturator replacement)* *\* Penicillin or Metronidazole given as empirical ABX. Swab taken which can be used to target ABx treatment.*
109
What are the main empirical antibiotics of choice for Acute Osteomyelitis? (3)
BROAD-SPEC ANTIBIOTICS E.g. * Benzylpenicillin * Clindamycin * Metronidazole *N.B. Clindamycin is good for bony penetration but risk of C.difficle bacterial infection → severe diarrhoea (cease meds)*
110
What is the: 1. OLD (3) 2. NEW (2) treatment for Osteoradionecrosis? Outline the preventative strategies for a pt about to undergo H&N radiation therapy.
1. OLD = Antibiotics, Hyperbaric Oxygen Therapy and Surgery 2. NEW = Pentoxifylline *(anti-fibrosis)* and Tocopherol (Vit. E) *(anti-oxidant)* Also: Pt education & Conservative tx (OHI, analgesia, trauma relief & CHX m/w) **Prevention RCS & BSDOH (2018) "Oral Management of Oncology Pts requiring Radiotherapy, Chemotherapy and/or Bone Marrow Transplantation"** * Full dental assessment: - Stabilisation - Relieve dental trauma - Extraction of poor prognosis teeth (at least 10 days before starting tx, ideally 3+ weeks) * High risk Prevention - Fluoride (TP, FV, m/w) - Dietary advice alongside dietician - Reduced recall * Education on acute & chronic side effects of radiotherapy
111
Do you prescribe antibiotics for: 1. Dry Socket? 2. Osteomyelitis? 3. Osteoradionecrosis? 4. MRONJ?
1. NO - This is primarily inflammation! 2. Yes (Empirical ABs them targetted ABs based on pus sample and 2 week course, OPAT) 3. Yes, if infection present (But new tx = Pentoxifylline & Tocopherol) 4. No evidence for use
112
What are 8 local haemostatic measures that can be used to manage bleeding?
1. Pressure with (saline-soaked) gauze 2. LA (adrenaline vasoconstrictor) 3. Pack socket with oxidised cellulose (surgicel) 4. Suturing 5. Transexamic acid mouthwash (5% QDS) *- N.B. Not recommended by SDCEP* 6. Bone wax 7. Diathermy (of vessel) 8. Suck down splint (more often for fractures)
113
What is pericoronitis? What type(s) can be considered for 3rd molar extraction?
Soft tissue inflammation related to crown of partially erupted tooth, where presence of an overlying operculum makes difficult to clean. (Build up of plaque, streptococci and anaerobic bacterium) Considered for XLA if: 1 severe episode or multiple reoccuring episodes
114
A patient presents with mucositis related to onset of chemo/radiotherapy: What is it & how does it present? When does it present? How can it be managed?
Mucositis = Acute inflammation of mucosa May present as: Ulceration, erythema & white/yellow sloughing. Patients may complain of pain on eating/swallowing/speaking. Often presents 1-2wks following cancer therapy onset. Pt should be reassured - healing is often complete 2-3wk following cessation of therapy. Management: Reassurance (above), OHI, topical agents (e.g. difflam, CHX mouthwash, lidocaine gel/ mouthwash), mucosal shields during radiotherapy & zinc supplements
115
What are the 3 main treatment principles/stage for dental abscesses? How does each differ for GDP & OMFS?
**1) Drain Pus (Aspiration, Intra/Extra Oral Drainage)** * **GDP =** Intra-oral drainage (LA) * **OMFS** = Intra OR Extra-oral drainage (LA or GA) **2) Remove Cause/Source of Infection** * **GDP** = Extirpation or Extraction * **OMFS** = Extraction * *3) Consider Antibiotics** * (If incomplete drainage, severe infection (spread/fever) or MH concern, e.g. diabetic)* * **GDP =** Oral empirical Antibiotics (e.g. Penicillin or Metronidazole) * **OMFS** = IV antibiotics (empirical initially, thenm can give more specific after lab results from sample)
116
What is the OS management of patients on NOACs? How would this change if it was an emergency?
RIVAROXABAN/EDOXABAN (taken OD - morning or evening) * DELAY morning dose & take 4hrs after hameostasis * Take evening dose as normal (given 4hr post-haemostasis) APIXABAN/DABIGATRAN (taken BD) = MISS morning dose & take evening dose as normal SDCEP: "In emergencies where the patient has taken their morning NOAC dose, advisable to try and delay treatment to later in the day if possible to reduce anticoagulant effect"
117
What is SDCEPs stance on Tranexamic acid?
* TA is NOT included in BNF Dental Preparations list and so cannot be prescribed on the NHS * TA not available as m/w and so must be prescribed & prepared off licence * "Based on this guidance, not advised _primary care practitioners_ prescribe TA but can be used in addition to local haemostatic measures if presecribed by medical practicioner"
118
What are the 4 para-nasal sinus'? Which is the largest?
Frontal, Ethmoid, Sphenoid & Maxillary Maxillary = largest (3x3x2.5cm) Pryamid-shaped (base on lateral nasal wall & apex in zygomatic process)
119
What arteries & nerves are associated with the maxillary antrum?
_Arteries:_ * Greater Palatine * Facial * Maxillary _Nerves:_ * Superior Alveolar * Anterior Palatine * Infra-orbital
120
What is the difference between an OAC & OAF?
OAC (Oro-Antral Communication) = **full thickness** open communication between oral cavity & maxillary sinus; often following XLA upper molars (esp. 2nd molars) OAF (Oro-Antral Fistulae) = An OAC which has **epitheliazed** over time; NOT present immediately after XLA
121
What are 7 factors pre-disposing a patient to an OAC?
1. Close proximity/relationship between tooth & antrum 2. Excessive apical force used in XLA 3. Surgery performed in close proximity to sinus (e.g. cyst removal) 4. Submerged teeth 5. Larger antrum 6. PA Bone loss (destruction of peri-apical bone) 7. Hypercementosis
122
What are the _signs_ (6) & _symptoms_ (3) of an OAC? (N.B. Some immediate & some delayed)
_Signs:_ 1. Direct expection under good lighting - Hole evident 2. Bone/antral lining on extracted tooth roots 3. Blood 'bubbling' at socket 4. Hollow sound on suction of socket 5. Whistling noise from socket 6. Radiographs showing antral floor defect (not always visible & not needed for acute diagnoses) _Symptoms:_ 1. Air entry into mouth on holding nose 2. Regurgitation of fluids/foods into nose 3. Symptoms of sinusitis if untreated (dull pain worse on bending forwards +/- purulent discharge S*tudies have suggested in untreated larger OACs, 50% develop sinusitis within 2 days & 90% within 2 weeks*
123
What is the management & POIG/POAR for a patient with OAC? (POAR = Post-Operative Antral Regime)
[Ideally prevention: consent for risk & elective surgical?] **Small OAC?** (\<2mm) = Horizontal mattress suture & review for spontaneous closure. **Large OAC?** (\>5mm**)** = Surgical site closure: Buccal advancement, Buccal fat-pad advancement, Palatal rotational/"Pedicle" or Tongue flaps * _Consider:_ - construction of suck-down acrylic plate/ essex splint to protect area for first 2 weeks - surgicel placement (but may provoke inflammatory foreign body response)* *- Autogenous/ Allogenous/ Xenografts* **_POIG/POAR:_** * AVOID: Nose blowing, use of straws, sneezing with mouth closed, smoking, use of wind instruments, swimming/snorkelling, airplanes or blowing balloons/mattresses for 2-3weeks * Soft diet & avoid trauma to area * NSAID analgesia * Steam inhalations (Karvol/Olbas oil) * Nasal decongestants (0.5% Ephedrine) for 7 days * Antibiotics *(FGDP 2020- Antimicrobial Prescibing in Dentistry)* - Phenoxymethylpenicillin - 500mg QDS for 5 days - Doxycycline - 200mg OD (1day) then 100mg OD (4days) - Clarithromycin - 500mg BD for 5 days * Anti-septic or Saline rinses * Safety net the patient: contact details & red-flags (sinusitis, swelling, epistaxis)
124
What antibiotics could be prescribed for an OAC/OAF? (Quote guidelines)
_FGDP (2020) Antimicrobial Prescribing in Dentistry_ 1st Line: **Pentoxymethylpenicillin - 500mg QDS for 5 days** 2nd Line: * **Doxycycline - 200mg OD (1 day) & 100mg OD (4 days)** * **Clarithromycin - 500mg BD for 5 days**
125
What is an OAF? What are the signs & symptoms?
**Oroantral Fistulae =** **_Epithelialised_** communication between oral cavity & maxillary sinus (epithelialisation begins to occur a few days following OAC formation) *OAF could be caused by: Non-healing OAC, draining infection, trauma or malignancy* _Signs:_ * Visible fistula * Antral mucosa may prolapse into mouth ('antral polyp') * Whistling sound on talking/breathing * Fogging of dental mirror placement at site * Radiographic: Fluid in sinus & tear in antral lining _Symptoms:_ * Fluid/food regurgitation * Epistaxis * Chronic sinusitis (may be asymptomatic or dull throbbing pain +/- nasal discharge)
126
What is the treatment/management of an OAF? What are the complicating factors in its management?
_Complicating factors:_ * Clean antrum required before surgery (often given ABx before) * OAF tissue friability (two epithelialised edges wont heal) so fistulae tract must be exised _Management:_ * Pre-op ABx * Exision of fistulae tract * Surgical closure: Buccal advancement flap/Buccal fat pad/Palatal flap * POIG/POAG (as with OAC) \* POIG/POAR: * AVOID: Nose blowing, sneezing with mouth closed, use of straws, use of wind instruments or blowing balloons/mattresses * Soft diet & avoid trauma to area * NSAID analgesia * Steam inhalations (Karvol/Olbas) * Nasal decongestants (0.5% Ephedrine - 7 days) * ABx * Anti-septic mouthrinse * Safety net for complications & contact
127
What are 5 pre-disposing factors for maxillary tuberosity fracture? How would you diagnose it?
1. Lone standing maxillary molars 2. Excessive force 3. Hypercementosis 4. Bulbous or splayed roots 5. Large antrum Visualy & Tactile diagnosis: * Would feel/see movement of the tooth AND bone together * +/- Palatal tear * +/- Fracture sound
128
What is the management for a: 1) SMALL 2) LARGE fracture of the maxillary tuberosity?
1) SMALL FRACTURE * Raise buccal flap (visualisation) & dissect tooth from bone * Extract tooth & close site (buccal flap) to avoid OAC * POIG/POAR 2) LARGE FRACTURE * STOP... DO NOT EXTRACT * Splint to neighbouring tooth & leave for 6-8 weeks * Consider placing patient on ABx * Reassess and extract under elective surgical
129
What is the management of displaced roots/teeth? (minimally invasive → most invasive)
* Suction retrieval (careful not to displace further apically) * Radiographic visualisation (parallax or CBCT) *if not visualised here, consider Chest X-ray for possible aspiration* * Close OAC & refer to OS * POIG/POAR OS: - Beneath antral lining?Buccal mucoperiosteal flap & careful bone removal - Above antral lining? Cadwell-Luc Surgery or Intra-nasal Antrosomy
130
BDJ Article: What are 8 factors influencing the success of surgical management of OAFs?
1. Size of lesion 2. Previous surgery 3. Pre-existing sinus pathology 4. Experience of operator 5. Surgical techniquer used 6. OH 7. Smoking 8. Medical status
131
What is Sinusitis? What are the main aetiological causes? (3) What are the 2 main types and how do they differ in presentation?
Inflammation of the paranasal sinus _Aetiology:_ * Infection - Viral (Influenza, Common Cold, Measles), Bacterial (Whooping cough or severe dental infection spead) or Fungal (rare) * Decreased drainage (e.g. obstruction) * Iatrogenic penetrating injury (e.g. displaced tooth) **1) ACUTE** Constant, throbbing pain with exacerbated tenderness on leaning forwards Facial swelling, cheek oedema, teeth may be TTP (but are vital) Systemic: Pyrexia, malaise, lymphadenopathy **2) CHRONIC** (persistant inflammation, usually lasting at least 3 months) Asymptomatic or nagging pain (less severe than acute)
132
What are the 2 main techniques used to surgically close an OAC? How do they differ in advantages/disadvantages?
1) BUCCAL ADVANCEMENT FLAP Advantages: Most common, high success rate Disadvantages: Decreased buccal sulcus depth, Future prosthetic issues & post-op pain/swelling 2) BUCCAL FAT PAD FLAP Advantages: Quick, good blood supply, buccal sulcus depth unaffected & high success rate Disadvantages: Reduced mouth opening, partial necrosis & post-op pain/swelling
133
What are 4 drugs NOT prescribed as anti-coagulants or anti-platelets which can still effect clotting (& why)?
1. Cytotoxics (e.g. Penicillamine, Hydrochloroquine, Azthioprine, Methotrexate) - Reduce platelet numbers and/or impair liver function (production of clotting factors) 2. NSAIDs - Impair platelt function 3. Carbamazepine - Can affect liver & bone marrow platelet production (most at risk when first started medication or following dose adjustment) 4. SSRIs (e.g. Citalopram, Fluoexetine, Sertraline) - Potential to impair platelet aggregation & may increase bleeding time when used with anti-platelets
134
What are 4 signs/symptoms shared in both Acute & Chronic Sinusitis?
* Dull, throbbing pain in midface - may be worse on leaning forwards (more severe in acute) * Mucopurulent nasal discharge * Lack of transillumination * Radiographic opacity
135
What are 8 signs/symptoms of Acute Sinusitis? What are the main principles of its management?
_Signs/Symptoms:_ * Dull, constant throbbing pain in midface - especially on leaning forward * Facial swelling/ cheek oedema * Mucopurulent discharge * Teeth TTP but vital * Loss or altered smell/taste * Systemic: Pyrexia, Malaise & Lymphadenopathy * Lack of transillumination * Radiographic opacity _Management:_ ***ARABS:*** **_A_**nalgesia **_R_**eassure (if secondary to viral infection often self-limiting) **_A_**nti-biotics *(only if persistant or severe symptoms)* **_B_**ed-rest/fluids **_S_**team inhalation (& Nasal decongestants - 0.5% Ephedrine max 7 day use) If unresponsive/severe, may require surgical management: Antral wash-outs or Intra-nasal Antrostomy
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According to SDCEP, when should antibiotics be prescribed for Sinusitis? (2) What antibiotics are recommended?
1. Severe systemic symptoms 2. Persistent symptoms and/or mucopurulent discharge lasting at least 7 days _Antibiotics:_ * Amoxicillin 500mg TDS for 7days * Doxycyclin 200mg OD for 1 day & 100mg OD for 6 days
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What are 6 signs/symptoms of Chronic Sinusitis? What is the management? How does this differ to Acute?
_Signs/ Symptoms:_ * Asymptomatic or dull 'nagging' pain * Mucopurulent discharge * Nasal obstruction * Thickened antral mucosa * Loss of transillumination * Radiographic opacity * Halitosis * Loss/ altered smell & taste _Management:_ ***ARABS:*** Analgesia, Reassure (non-dental), Anti-biotics (not routine), Bed-rest & fluids, Steam inhalation Surgery: Antral washouts, Intra-nasal antrostomy, Cadwell-Luc or FESS (Functional Endoscopic Sinus Surgery) Vs Acute: May not respond to local measures as well & avoid nasal decongestants for chronic as may worsen
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What are 4 predisposing factors for Acute Sinusitis?
1. Poor drainage 2. Deviated septum 3. Virulent infection 4. Immunocompromised/Dehabilitated patient
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Why do lesions that are normally radio-lucent (e.g. cysts) appear radio-opaque in the maxillary sinus?
As theyre surrounded by less dense air
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What are two classifications for impacted wisdom teeth?
1. **Winter's Classification (8)** Using Winter's Lines, assess if application point is mesial/distal and above or below the 'amber' line (bone level) or 'white' line (occlusal plane) ***Mesio-angular, Disto-angular, Vertical, Horizontal, Inverted, Buccal-oblique, Lingual-oblique or Transverse*** 2. **Pell & Gregory Classification** Class: A-C (height of impacted tooth) & I-III (space available between distal border of 7 & anterior border of the ramus for the 8s eruption)
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What is the ASA Classification?
ASA 1 = Normal, healthy patient ASA 2 = Mild systemic disease (includes smoker, drinker & obesity!) ASA 3 = Severe systemic disease (includes uncontrolled DM) ASA 4 = Severe systemic disease, constant threat to life ASA 5 = Moribund patient, not expected to survive without surgery ASA 6 = Clinically brain-dead
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What is the general appearance of a mucocele? What are the 3 main types & how do they differ in aetiology/appearance/histology?
_Clinical Presentation_ * Blue-ish, translucent swelling * Fluctuant * Sessile (fixed) * Painless * May burst to release "salty" mucous _Types:_ 1. Mucous Extravasation Cyst - Related to trauma so often on lower lip - No epithelial lining (seen histologically alongside inflammatory cells) 2. Mucous Retention Cyst - Related to saliva retention, not often on lower lip and more common in older pt (\>50y) - Epithelial lined (seen histologically & NO inflammatory infiltrate) 3. Ranula - (Often MEC) affecting SM/SL gland in FoM (uniform ~2-3mm) - "Plunging Ranula" if extends through Mylohyoid
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What are the 3 main treatment options for a mucocele?
1. No tx & monitor (may spontaneously resolve) 2. Surgical excision or marsupialisation 3. Cryotherapy (if reoccurance)
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What are 8 types of Ondontogenic Cysts? Which 3 are the most common?
_Inflammatory:_ 1. Radicular Cyst *(most common, 65%)* 2. Residual Cyst 3. Paradental Cyst _Developmentary:_ 1. Dentigerous Cyst (Follicular/Eruption) - *25%* 2. Odontogenic Keratocyst - *5%* 3. Lateral Periodontal Cyst 4. Gingival Cyst of the Adults 5. Glandular Odontogenic Cyst
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What are the GENERAL: 1. Clinical features 2. Special Investigations 3. Treatments For all Odontogenic cysts?
**_Clinical Features:_** * Painless swelling (may become painful if secondary infection) * Egg-shell crackling (breaking of overlying periosteal bone) or Fluctuance (ST or perforated bone) * Displacement or mobility of teeth **_Special Investigations:_** 1. Sensibility tests (Radicular cysts associated with non-vital teeth) 2. Radiographs (often: well-defined, well-corticated radiolucencies) ​ 3. Biopsy - Aspiration (OKC - White-yellow semifluid & low soluble protein level \<4g/100mL) - Incisional Biopsy (larger lesion) - Excisional Biopsy (smaller lesion) **_Treatments:_** Enucleation or Marsupialisation (RCT considered for small Radicular Cysts & Eruption cysts may spontaneously resolve)
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What are 8 Non-Odontogenic Cysts? (Epithlial & Non-Epithelial)
_Epithelial:_ 1. Naso-Palatine 2. Naso-Labial 3. Median Palatine 4. Mucous Retention Cyst _Non-Epithelial:_ 1. Solitary Bone Cyst 2. Aneurysmal Bone Cyst 3. Mucous Extravasation Cyst *(N.B. Bone Cysts most often associated with children/adolescents)*
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What are the general clinical features of a Mucocele? (6) What are the 3 main types & how do they differ? What are the 3 main treatment options?
_Mucocele Clinical Features:_ Swelling (salivary gland cyst): * Blue-ish * Translucent * Fluctuant * Sessile * Painless * May burst to release "salty" mucous 1. **Mucous Extravasation Cyst** Associated with trauma (often on lower lip), NOT epithlieal lined Histology: No epithelium, mucous & inflammatory cell infiltrate 2. **Mucous Retention Cyst** Associated with saliva retention (often older pt \>50y & not commonly found on lower lip) Histology: Epithelial lined, mucous & NO inflammatory infiltrate 3. **Ranula / "Plunging Ranula"** Often **MEC** of SL/SM gland on FoM (unilateral, 2-3cm) **"PR****"** if extends through mylohyoid _Treatment Options:_ 1. No treatment/ Monitor (can spontaneously resolve) 2. Surgical: Excision or Marsupialisation 3. Cryotherapy (e.g. if recurrence)
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When assessing radiograph of potential cyst/tumour - What should be described?
Radiolucency or/and Radiopacity: 1. Site (& any association with unerupted teeth - e.g. Dentigerous/OKC) 2. Size 3. Shape (cysts often oval or round) 4. Margin (cysts often well-defined & well-corticated) 5. Locularity -Uni/Multi 6. Effect on adjacent structures (e.g. root resorption or displacement)
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What are the specific clinical, radiographical & histological features for a Radicular Cyst?
_Clinical Features:_ Associated with NON-VITAL tooth (apex or laterally) _Radiographic Features:_ * Well-defined & Well-corticated R/L * Round or Ovoid * Unilocular * Associated with apex of non-vital tooth, growth continuous with lamina dura of TIQ * LT ⇒ Root Resorption or Displacement _Histological Features:_ * Non-keratinised SS Epithelium * **Acute & Chronic Inflammatory Infiltrate** * **Cholesterol Clefts** (in cell wall & lumen) * Mucous Metaplasia * Lumen: Pink serous exudate, Inflammatory cells, Desquamated epithelial cells & Cholesterol Clefts * May see GP/Amalgam if root-filled *
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What are the specific Clinical, Radiographical & Histological features of a Dentigerous Cyst?
_Clinical Features:_ Associated with UNERUPTED tooth (often 8s or 3s) _Radiographic Features:_ * Well-defined & well-corticated radiolucency * Unilocular (or pseudo multilocular) * Unerupted TIQ lies centrally with cyst attached at CEJ * Follicular space \> 3mm (if less, consider if enlarged follicle) _Histological Features:_ * Non-keratinised SS Epithelium * **Flat Basement Membrane (uniform, 2-5 cells thick)** * **"Blue myxoid" Cell wall** * **Mucous Metaplasia** * Lumen: Pink serous exudate & Cholesterol Clefts
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What are the specific Clinical, Radiographic & Histological features of an Odontogenic Keratocyst?
_Clinical Features:_ * Associated with unerupted tooth * Aspiriation ⇒ White/Cream semi-fluid & Low protein level (\<4g/100mL) * Multiple Cysts - Gorlin Goltz Syndrome * High (60%) recurrence rate! *(diffiucult removal & daughter cells)* _Radiographical Features:_ * Well-defined & Well-corrugated (**"scalloped"**) radiolucency * Multi-locular (or uni) * Common: Angle of Mandible or Ramus _Histological Features:_ * **Keratinised & Corrugated** SS Epithelium * **Flat Basement Membrane** * **Daughter Cell**s (in cyst wall) * **Prominant Basal Cells** (dark stain & reverse nuclear polarity)
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What is the incidence of MRONJ? (HINT: By treatment need & rate increases for post-extraction)
``` Cancer pt (Anti-Angiogenics or Anti-Resorptives) = ~1% **(2.9% after XLA)** ``` ``` Osteoporosis Pt (Anti-Resorptive) = 0.01-0.1% **(1.5% after XLA)** ```
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According to AAOMS (2014 Position Paper), what are the MRONJ treatment goals? (4)
* Prioritise oncology * Preserve Quality of Life through: - Pt education & reassuremetn - Control pain & secondary infection - Prevent lesion extension & new necrosis
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What are 4 risk factors for ORN?
1. Radiation dosage (above 60Gy) 2. Large dose fraction & high frequency of fractions 3. Trauma to area of irraduation 4. Immunocompromised pt
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What are some clinical features of ORN?
If sterile, necrotic bone may remain asymptomatic. _Infected:_ * Pain (deep-seated/throbbing) * Necrotic bone * Suppuration * Bony sequestra * LT ⇒ Pathological # risk