Oral Sedation and Anxiety Control Flashcards

1
Q

The dissociation constant has to match the pH of the compartment for the drug to be absorbed.

A

True

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2
Q

Some drugs need these to be broken down.

A

Bile salts or bacteria.

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3
Q

Why do anti-cholinergics delay gastric emptying?

A

Because the stomach is stimulated by the Vagus nerve, which is cholinergic.

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4
Q

These three things cause delayed gastric emptying.

A

Diabetes, Scleroderma, Amyloidosis

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5
Q

The fraction of the drug dose that gets into the systemic circulation.

A

Bioavailability

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6
Q

T/F: You cannot titrate oral sedatives.

A

True

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7
Q

First pass metabolism of a drug occurs in what organ?

A

Liver

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8
Q

Diffusion from high to low concentration.

A

Passive diffusion

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9
Q

These molecules diffuse more readily.

A

Small, non-polar lipid soluble molecules

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10
Q

What is ion-pair transport?

A

Anions bind to Cations to form a neutral complex that can pass the cell membrane by passive diffusion.

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11
Q

These:

  • Reversibly associated with the drug
  • Buffer wide fluctuations in free drug concentration
A

Plasma proteins

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12
Q

If the drug readily binds to these, they will stay in the body longer.

A

Plasma proteins

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13
Q

Obesity and drug distribution

A

Obese people with large lipid stores hold onto the drug longer.

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14
Q

Metabolism of a drug involves this.

A

Conversion from lipid to water soluble.

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15
Q

Where most agents get metabolized.

A

Liver

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16
Q

Phase I reactions in drug metabolism involve what?

A

Oxidation
Reduction
Hydrolysis

17
Q

Phase II reactions in drug metabolism

A

Conjugation

18
Q

The drug is combined with glucuronic acid to form water soluble complexes.

A

Conjugation

19
Q

Most drugs are eliminated through which organ?

A

Kidneys

20
Q

What is this? :

Drug is conjugated with biliary salts, goes through the intestinal tract, and gets recycled and reabsorbed.

A

Enterohepatic cycling

21
Q

What kind of sedation is not recommended for kids under 12?

A

Moderate

22
Q

Types of sedation

A

Mild
Moderate
Deep

23
Q

May need to maintain the airway in this type of sedation.

A

Deep

24
Q

Patients cannot be easily aroused during this type of sedation.

A

Deep

25
Q

Stages of Anesthesia

A

Stage 1, 2, 3, 4

26
Q

Stage 1 Anesthesia

A

Analgesia

27
Q

Stage 2 Anesthesia

A

Delirium/Excitement

28
Q

Stage 3 Anesthesia

A

Surgical Anesthesia

29
Q

Stage 4 Anesthesia

A

Medullary Paralysis

30
Q

Minimally depressed level of consciousness.

Cognition and Coordination are modestly impaired.

Ventilatory and cardiovascular functions are un-impaired.

A

Minimal sedation

31
Q

This type of sedation:

patients respond to verbal commands alone or accompanied by light tactile stimulation.

A

Moderate sedation

32
Q

Drug induced loss of consciousness in which patients are not arousable even by painful stimulation.

A

General Anesthesia

33
Q

Requires a device to maintain a patent airway.

CV function may be impaired.

A

General anesthesia.

34
Q

If lower BP more than this %, can cause brain damage bc not enough pressure to pump blood to the brain.

A

25

35
Q

Oxygenated Hb absorbs _____ light at ____ nm.

A

Infrared; 990

36
Q

You regain full psychological and physical capacity in this stage of recovery.

A

Late

37
Q

You regain full psychomotor function and resume physical activity in this stage of recovery.

A

Intermediate

38
Q

Used as discharge criteria.

A

Aldrete Scoring System

39
Q

Characteristics looked at for the Aldrete System

A
Activity
Respiration
Circulation
Consciousnes
Color