Oral Sedation and Anxiety Control Flashcards
The dissociation constant has to match the pH of the compartment for the drug to be absorbed.
True
Some drugs need these to be broken down.
Bile salts or bacteria.
Why do anti-cholinergics delay gastric emptying?
Because the stomach is stimulated by the Vagus nerve, which is cholinergic.
These three things cause delayed gastric emptying.
Diabetes, Scleroderma, Amyloidosis
The fraction of the drug dose that gets into the systemic circulation.
Bioavailability
T/F: You cannot titrate oral sedatives.
True
First pass metabolism of a drug occurs in what organ?
Liver
Diffusion from high to low concentration.
Passive diffusion
These molecules diffuse more readily.
Small, non-polar lipid soluble molecules
What is ion-pair transport?
Anions bind to Cations to form a neutral complex that can pass the cell membrane by passive diffusion.
These:
- Reversibly associated with the drug
- Buffer wide fluctuations in free drug concentration
Plasma proteins
If the drug readily binds to these, they will stay in the body longer.
Plasma proteins
Obesity and drug distribution
Obese people with large lipid stores hold onto the drug longer.
Metabolism of a drug involves this.
Conversion from lipid to water soluble.
Where most agents get metabolized.
Liver