Oral meds CDE

Question 1

Metformin adverse reaction

Answer 1

Lactic acidosis in renal insufficiency
GI upset
B12 deficiency

Question 2

Metformin mechanism of action

Answer 2

Inhibit hepatic glucose release
Increase peripheral glucose uptake
Increase glycolysis

Question 3

Sulfonylureas (name a few)

Answer 3

Glimepiride
Glipizide
Glyboride

Question 4

Sulfonylureas mechanism of action

Answer 4

Close ATP-sensitive K channels ,initiating chain of events that results in insulin release

Question 5

Sulfonylureas adverse event

Answer 5

Hypoglycemia
Possible increase in CV risk and mortality

Question 6

Meglitinides ( name a few)

Answer 6

Nateglinide
Repaglinide
Mitiglinide

Question 7

Meglitinides mechanism of action

Answer 7

Similar to sulfanylureas
Directly stimulate release of insulin from pancreatic beta cells

Question 8

Meglitinides adverse event

Answer 8

Hypoglycemia

Question 9

Meglitinides key info

Answer 9

Good choice for pts with erratic eating pattern
Good for pts with low renal function

Question 10

DPP4 inhibitors mechanism of action

Answer 10

Inhibit DPP4 therefore potentiating GLP1
Increasing insulin release and inhibits glucagon release

Question 11

DPP4 inhibitors AE

Answer 11

UTI
Respiratory infections
(Liptin makes you PP4 more times)

Question 12

DPP4 inhibitors ( name a few)

Answer 12

Sitagliptin
Saxagliptin
Linagliptin
Alogliptin

Question 13

GLP1 Agonists

Answer 13

Increase GLP1 reaction leading to increased production of insulin and inhibits glucagon release

Question 14

GLP1 Agonists (name a few)

Answer 14

Semaglutide (rybelsus) (oral once a day)

Exenatide ( Bydureon) (injection 1x week)

Semaglutide ( ozempic) (injection x1 week)

Dulaglutide (trulicity) (injection x1 week)

Liraglutide (victoza) (injection x1 week)

Question 15

GLP1 Agonists AE

Answer 15

Pancreatitis
Contraindicated with thyroid cancer hx