Oral Medicine Flashcards
what does ICOP stand for
international classification of orofacial pain
what are the 2 main systems used in orofacial pain classification
- international classification of headache disorders 2018
- international classification of orofacial pain 2020
what 5 categories are within orofacial pain attributed to disorders of dentoalveolar and anatomically related structures
- tooth related pain
- pain from periodontium
- pain from oromucosa
- pain from salivary glands
- pain from bone
what type of pain do groups 2 and 3 of ICOP include
TMJ pain/ disorders
which nerves are of significance in orofacial pain attributed to lesion or disease of the cranial nerves
- trigeminal
- glossopharyngeal
what two categories are within pain attributed to lesion or disease of the trigeminal nerve in ICOP
- trigeminal neuralgia
- painful trigeminal neuropathies
what two categories are within pain attributed to lesion or disease of the glossopharygeal nerve
- glossopharyngeal neuralgia
- painful glossopharygeal neuropathies
what is the most widely accepted classification of orofacial pain
ICHD3
what 4 categories are within orofacial pains resembling presentations of primary headaches
- migraine
- tension headache (TTH)
- trigeminal autonomic cephalalgias (TACs)
- other primary headache disorders
what 3 categories come under idiopathic orofacial pain
- burning mouth syndrome
- persistent idiopathic facial pain
- persistent idiopathic dentoalveolar pain
what is an innocuous stimulus
something that wouldnt normally give rise to pain
what is trigeminal neuralgia
recurrent unilateral pains, abrupt in onset and termination
does trigeminal neuralgia always have a cause?
no, may develop on its own or as a result of another diagnosed condition
what may come along with the short sharp pains of trigeminal neuralgia
continuous moderate pain in the distribution of the affected nerve(s)
how long will trigeminal neuralgia pain last
a few seconds - 2 mins
what does the pain of trigeminal neuralgia feel like
severe, sharp
what is the pain of trigeminal neuralgia caused by
innocuous stimulus
give an example of innocuous stimulus
yawning
what is the final part of diagnosing trigeminal neuralgia
not better accounted for by any of the other ICHD-3 diagnosis’
what is the incidence of trigeminal neuralgia
4-13:100,000
what age does trigeminal neuraligia often affect
50-60
what age group is trigeminal neuralgia very uncommon in
less than 40
what would be suspicious of if a ot under 40 has trigeminal neuralgia
underlying disease process
what gender does trigeminal neuralgia affect more
female
what are the risk factors for trigeminal neuralgia
stroke
hypertension
is trigeminal neuralgia usually bilteral or unilateral
unilateral
which side of the face does trigeminal neuralgia affect more commonly
right
what would you suspect if a pt has bilateral trigeminal neuralgia
underlying disease process
what % of trigeminal neuralgia affects the opthalmic division
<5%
what % of trigeminal neuralgia is related to dental Tx or disease
22%
what might dental Tx or disease cause trigeminal neuralgia
sensitisation of the nerve
what % of pts consult a dentist first for trigeminal neuralgia
27%
what % of pts have pain free periods in trigeminal neuralgia
73%
what % of pts have a provoking factor in trigeminal neuralgia
96%
what is often a relieving factor for pts with trigeminal neuralgia
warmth and rest
what is the refractory period in trigeminal neuralgia
time after the pain where the trigger will no longer illicit a response
why is lachrymation an associated factor of trigeminal neuralgia
as pain so severe
what other conditions may be associated with trigeminal neuralgia
depression and anxiety
if the pain of trigeminal neuralgia is so bad, what may you be concerned about for your pt
suicide risk
what are the 3 classifications of trigeminal neuralgia
- classical trigeminal neuralgia
- secondary trigeminal neuralgia
- idiopathic trigeminal neuralgia
what is classical trigeminal neuralgia
develops without apparant cause other than neurovascular compression
what does compression of the nerve in trigeminal neuralgia cause that results in pain
demyelination of the nerve
where will morphological changes occur in classical trigeminal neuralgia
trigeminal nerve root
where is the trigeminal nerve root
posterior cranial fossa
how can you demonstrate the compression of nerves in classical trigeminal neuralgia
MRI
surgery
what usually cause the compression in classical trigeminal neuralgia
blood vessel
where is the area of most vulnerability for classical trigeminal neuralgia
root entry zone
why is the root entry zone the area of most vulnerability for classical trigeminal neuralgia
where the peripheral and central myelins of schwann cells and astrocytes meet
describe the symptoms of classical trigeminal neuralgia
classical trigeminal neuralgia with persistent background facial pain
what is secondary trigeminal neuralgis caused by
underlying disease
what will a clinical exam of a pt with secondary trigeminal neuralgia show
significant sensory changes
what distinguishes secondary from classical trigeminal neuralgia
a diagnosis of underlying disease known to cause neuralgia
name 2 diseases known to cause secondary trigeminal neuralgia
MS
space occupying lesion eg tumour
what age group do secondary trigeminal neuralgia belong to
<30
is secondary trigeminal neuralgia bilateral or unilateral
bilateral
what imaging should be taken for trigeminal neuralgia
MRI
what is idiopathic trigeminal neuralgia
trigeminal neuralgia with no tests showing significant abnormalities
how is idiopathic trigeminal neuralgia often diagnosed
neither classical or secondary trigeminal neuralgia has been confirmed by any tests
what must an exam for trigeminal neuralgia include
cranial nerve exam –> CNV
what areas are imaged in an MRI for trigeminal neuralgia
head and internal auditory meatus
what is the diagnosis of facial pain reliant on
pain history
who should the GDP liaise with for trigeminal neuralgia
GP
oral med
when should there be urgent referral to a specialist oral med
- sensory/ motor deficits
- deafness/ ear problems
- optic neuritis
- history of malignancy
- bilateral TN pain
- systemic symptoms - fever, weight loss
- presentation in pts <30
what is the first line pharmacological Tx for trigeminal neuralgia
carbamazepine
can GDPs prescribe carbamazepine
yes
what can pts contraindicated/ not tolerant of carbamazepine take for trigeminal neuralgia
oxycarbazepine
what is the brand name for carbamazepine
tegretol
what type of drug is carbamazepine
anticonvulsant
what is carbamazepine liscensed for
bipolar and epilepsy
how does carbamazepine work
binds to voltage dependant Na channels inhibiting action potential
where is carbamazepine metabolised
liver
what enzymes metabolise carbamazepine
CYP3A4
why is the enzyme that metabolises carbamazepine important?
interactions with drugs that are metabolised by the same systems
what causes reduction of efficacy sometimes seen after the first few weeks of carbamazepine Tx
induces its own metabolism
what % of carbamazepine is excreted in the urine
70
what ethnicity of pts should carbamazepine not be prescribed to
han chinese/ thai origin
why can carbamazepine not be prescribed to han chinese/ thai pts
increased likelihood of steven johnsons syndrome
what testing is required to rule out steven johnsons syndrome
testing for HLAB*1502 allele
what does prescription of carbamazepine to steven johnson syndrome pts result in
extensive mucosal and skin ulceration and blistering
what can carbamazepine cause in pregnant pts
congenital malformations
what are 3 interacting drugs with carbamazepine
- st johns wort
- alcohol
- grapefruit
what advice must pts taking carbamazepine be given
how to recognise disorders of liver, skin and bone marrow
what is required if the pt on carbamazepine develops rash, fever, mouth ulcers, bruising or bleeding
immediate medical attention
what oral relevant side affect is there of carbamazepine
dry mouth
why are baseline blood tests taken for carbamazepine
potential effects on bone marrow, liver and renal function
what is the dose prescribed for carbamazepine
100mg x2 day for 1-3 days
what is the therapeutic range per day for carbamazepine
800-1200mg
what should be done once a trigeminal neuralgia pt taking carbamazepine is pain free for 4 weeks
trial dose reduction of carbamazepine
how often should monitoring blood tests be taken for pts on carbamazepine
weekly for first 4 weeks
then 1-3 monthly
what happens if a blood test for a pt on carbamazepine show abnormality
stop or dose reduction of carbamazepine
where can oxcarbazepine be prescribed
secondary care - not GDP
name 4 second line pharmacological Tx for trigeminal neuralgia
- lamotrigine
- baclofen
- gabapentin
- pregabalin
what additional management to pharmacological Tx can be given to pts with trigeminal neuralgia
- lidocaine nasal spray
- lidocaine ointment
- lidocaine as infil to trigger point
what dose of lidocaine nasal spray can be given to TN pts
10mg
when would lidocaine nasal spray be given to TN pts
for maxillary pain
where would lidocaine ointment be applied for TN pts
trigger point
what can a lidocaine infiltration to the trigger point of TN pts also be used as, as well as pain relief
diagnostic tool
what national support groups may be useful for TN pts
- trigeminal neuralgia association UK
what can be recommended to the pt if medication doesnt work to manage trigeminal neuralgia
surgery
when is surgery particularly relevant to trigeminal neuralgia
- medical management ineffective
- medication not tolerated
- medication contra-indicated
name 3 indications for surgery to managed trigeminal neuralgia
- short/no pain free period
- complications
- adverse affect on quality of life
what is done in surgical management of trigeminal neuralgia
palliative destruction at level of the grasserion ganglion
how is destruction of the grasserion ganglion done in surgery for trigeminal neuralgia
- radiofrequency thermocoagulation
- glycerol rhizolysis
- balloon compression
- steriotactic radiosurgery - gamma knife
what surgery is usually used in classical trigeminal neuralgia
microvascular decompression
what 3 surgeries can be used in trigeminal neuralgia
- microvascualr decompression
- partial sensory rhizotomy
- internal neurolysis
what surgery is done for trigeminal neuralgia if there is no neurovascular compression
neuroabalative procedure
what is the role of the GDP in trigeminal neuralgia
- diagnosis
- exclusion of dental pathology
- initiate medical treatment with GMP
- referral
what category does glossopharyngeal neuralgia come under
painful lesions fo the cranial nerves
what other distribution of nerve can glossopharyngeal neuralgia be felt?
vagus
where is pain often experienced in glossopharyngeal neuralgia
- ear
- base of the tongue
- tonsillar fossa
- beneath angle of mandible
what is glossopharyngeal neuralgia commonly provoked by
swallowing, talking and coughing
what divisions are there of glossopharyngeal neuralgia
- classical
- secondary
- idiopathic
what investigation would be done for glossopharyngeal neuralgia
MRI
what systemic management is there for glossopharyngeal neuralgia
carbamazepine
what other category of conditions is grouped in with glossopharyngeal neuralgia and trigeminal neuralgia under painful lesions of the cranial nerves
painful trigeminal neuropathies
name the 3 categories of painful trigeminal neuropathies
- painful trigeminal neuropathy attributed to the herpes zoster virus
- trigeminal post-herpetic neuralgia
- painful post-traumatic trigeminal neuropathy
what is allodynia
pain in response to a stimulus which would not normally cause pain
what is hyperalgesia
increased response to a stimulus which would normally cause pain
what is hypoalgesia
reduction in response to a stimulus which would normally cause pain
what is hyperesthesia
increased cutaneous/mucosal sensitivity to a stimulus
what is dysesthesia
unpleasant/ abnormal sensation affecting the skin or mucosa
what is pain in painful trigeminal neuropathies indicative of
neural damage
how does the primary pain in painful trigeminal neuropathies feel
continuous burning/squeezing
what may occur along with the primary pain in painful trigeminal neuropathies
brief pain that isnt the predominant pain type
how do the allodynic areas in painful trigeminal neuropathies differ from the trigger zones in trigeminal neuralgia
allodynic areas are much larger
what is painful trigeminal neuropathies attributed to the herpes zoster virus
unilateral facial pain of less than 3 months to one or more branches of the trigeminal nerve and associated symptoms of herpes zoster virus
what is acute herpes zoster
shingles
what is post herpetic painful trigeminal neuropathy
unilateral pain for more than 3 months caused by the herpes zoster virus
how can pts avoid shingles
vaccines
who can get the herpes zoster vaccine
70-79 year olds