Oral Liquid

Question 0

Semipolqr solvents may induce certain degree of _______ in Nonpolar molecules and may improve their _____ in polar solvents

Answer 0

Polarity

Miscibility

Question 1

Hydrocarbon and lipids cannot reduce attraction between ion of electrolyte and is said to have low ________

Answer 1

Dielectric constant

Question 2

Compendial requirement for water used in solvent preparation is ______, as required by USP

Answer 2

Purified water

Question 3

List 4 example of semi polar solvents

Answer 3

Ethanol
Glycol
Ketone
Ether

Question 4

The second most common solvent used in oral liquid dosage form is ______

Answer 4

Alcohol

Question 5

Both propylene glycol and Glycerin are alcohol solvent, they are _____, _____ and _____ liquid

Answer 5

Clear colorless viscous

Question 6

Glycerin is a ______ alcohol without the _______ activity of ethanol

Answer 6

Tirol

CNS depressant

Question 7

What solvent has humectant and preservative properties and is similar to ethanol in its solubilizing properties?p

Answer 7

Glycerin

Question 8

Both glycerin and propylene glycol has _____ and _____ properties, and they both have no ____ activities

Answer 8

Humectant
Preservative
CNS

Question 9

_____ is a polymer, it can range weight and physically can range from liquid to waxy.

Answer 9

PEG 400 NF

Question 10

Pharmaceutical solution are almost always unsaturated or saturated?

Answer 10

Unsaturated

Question 11

When heating drugs to increase the speed of dissolution, do not use concentration higher than the solubility at ______

Answer 11

Room temperature

Question 12

Define cosolvent systems

Answer 12

The mixing of solvent of different polarities to form a solvent system of optimum polarity to dissolve the solute

Question 13

The solvents in a cosolvent system must be _____ with on another

Answer 13

Miscible

Question 14

The more soluble the drug, the _____ it’s dissolution rate

Answer 14

Faster

Question 15

The solubility of a poorly soluble acidic substance is increased as the ____ of the medium is _____

Answer 15

PH

Increased

Question 16

One advantage of oral solution is that the active ingredient does not need to undergo ______, therefore _______ is faster than capsule and tablet

Answer 16

Dissolution

Therapeutic response

Question 17

One disadvantages of oral dosage form is its active ingredient are usually more susceptible to _______ , particularly ______ , than solid dosage form

Answer 17

Chemical degradation

Hydrolysis

Question 18

Elixirs, spirits and tincture are example of ______ solution

Answer 18

Hydroalcoholic

Question 19

Tap water may have _______, metal content which lead to less stability

Answer 19

Captopril

Question 20

Compressed tablet may be made by three basic methods

Answer 20

Wet granulation
Dry granulation
Direct compression

Question 21

Some granular chemicals, like potassium chloride possess free-flowing and adhesive properties that enable them to be compressed without any need for granulation, therefore _______ method is used

Answer 21

Direct compression

Question 22

Syrups have low _______ for water soluble drug, it is often best dissolved in ____ quantity of water

Answer 22

Initial solvent capacity

Small

Question 23

_______ inhibit oxidation by binding metal ions include did odium edetate and eidetic acid

Answer 23

Chelation agent

Question 24

Ascorbic acid, sodium metabisulfite, alpha-tocopherol are example of what?

Answer 24

Antioxidant

Question 25

Oxidation is a free radical process that leads to ______

Answer 25

Drug degradation

Question 26

Sucrose sorbitol mannitol are example of

Answer 26

Sweetning agent

Question 27

Syrup has strong _____ bonding

Answer 27

Hydrogen

Question 28

Aromatic water are clear saturated aqueous solution of _____ or other aromatic substance, an example is ___

Answer 28

Volatile oil

Peppermint water

Question 29

Aromatic water should be stored in _________ bottle to reduce violatlization and degradation from sunlight

Answer 29

Tight, light resistant

Question 30

Because elixir are hydroalcholic, they can dissolve either _____ ______

Answer 30

Alcohol soluble or water soluble drug

Question 31

Elixir are usually less ____ and less _____ than syrup

Answer 31

Sweet

Viscous

Question 32

Elixir alcohol content range from ___

Answer 32

5 to 40%

Question 33

Tincture has no _____ substance and is an alcoholic extract of ___ material

Answer 33

Volatile

Plant or animal

Question 34

Oral solution can support microbial growth if ______ is present

Answer 34

Sucrose

Question 35

Preservation can be accomplished in ____ alcohol, _______ surcrose or low temp

Answer 35

15-18

65-85