oral disease Flashcards
what is a cyst. why a radicular cyst might occur
a pathological cavity having fluid or semi-fluid contents, which has not been created by the accumulation of pus.
- not an abscess
-radicular= sequelae of periapical periodontitis
the 3 types of radicular cysts
Periapical= least common
Lateral= if lots of accessory canals
Residual- non-vital tooth has been extracted, cyst has not been treated and is left behind
signs and symptoms of a radicular cysts
-found at apex of non-vital tooth.
* Most common around the upper 2s
Presentation: Asymptomatic (if grossly carious), Pain ± Swelling, Tooth mobility / displacement
-Labial mucosa slightly bluish – compressible/ fluid filled qualities
-Has thinned labial plate of maxilla
-compressible
how cysts look on radiograph
- Site - apex of non-vital tooth. Or at extraction site
- Size - variable
- Shape – round & unilocular (just one cavity)
- Outline - well defined, corticated (got a clear white line around it) would be a tumour if not well defined outline
- Radiodensity - uniformly radiolucent
- Effects - buccal expansion (seen clinically), antral halo, root resorption (20%) & tooth displacement
-potential root resorption, loss of interradicular bone
what is an astral halo and cause
resorption of antral floor in maxilla as a cyst has remodelled the floor and pushed it up.
what is the structure and histopathology of a cyst
-Most are Lined by non-keratinised stratified squamous epithelium. And hyaline bodies
-wall made of inflamed fibrous tissue with cholesterol clefts (breakdown products of blood/lipid) and haemosiderin (breakdown of blood)
-lumen filled with dead cells
how a cyst forms
-Hertwig’s root sheath breaks down to form epithelial rests of Malassez
-Proliferation of cell rests of Malassez, stimulated by inflammatory mediators
-At apex of tooth, rests begin to develop and form islands of epithelium
-Over time, as things epithelialize, cells in centre will break down due to lack of blood supply
-Accumulation of dead cells – forms a cavity
-Hypertonic – will draw water across into cavity (osmosis) enlarges
-Enlarges by unicentric blooming
-Wall has the capacity to produce bone resorbing factors as it contains inflammatory cells – resorbing factors released allow cyst to grow
-Not neoplastic – will eventually stop growing (no unlimited growth potential)
can cysts heal
yes. Orthograde root filling with good coronal seal should allow healing, if not it is a true cyst as these are not joined to the apical Forman
what is the difference between periapical abscess and radicular cyst and periodical granuloma
abscess = no epithelium lining. filled with pus
cyst = lined by epithelium
granuloma - simple chronic inflammation at apex
difference between apical true and pocket cysts. which respond to RCT
Pocket cyst – will heal after cleaning root canal, with good irrigation, as joined to apical foramen
True cyst – cyst not joined up to apical foramen. So not healed by RCT
Type of biopsy needed for cancer and a cyst
cancer= incisional biopsy
cyst= fine needle aspiration
how stroke and Bell’s palsy (facial nerve) symtpoms differs in the forehead
stroke= forehead sparing- can wrinkle forehead
cranial nerve palsy =paralysed so unable to wrinkle
what does periodic acid Schiff, ziehl hellion and elastic van gleson help stain
- fungal
- acid fast (eg. TB)
- blood vessels
which tooth is most likely to cause orbital cellulitis
upper canine
what to do if someone comes in with Ludwig’s angina
ring local A&E who will have to incubate them
what is median rhomboid glossitis and causes
- a secondary form of candidosis
- symmetrical shaped area in midline of tongue
- Chronic infection
- Atrophy of the filiform papillae
- Associated with smoking & inhaled steroids
Actions of fluoride. what enzymes it inhibits
1-Reduces demineralisation: incorporated into outer layers, and in pits/ fissures. It can replace OH in calcium hydroxyapatite to make fluorapatite which is more stable and less acid-soluble
2-Promotes remineralisation: speeds up crystal precipitation, even at low pH, forming HA to mineralise the enamel.
3-Inhibits cariogenic bacteria: low plaque pH converts F to hydrofluoric acid which is taken up by bacteria. F ions released inside the cell which decrease microbial growth, metabolism and acid production by inhibiting enzymes. - inhibits pyruvate kinase and other enzymes to inhibit glycolysis so reduction in nutrients and reduction in lactic acid production
- inhibits ATP-ase proton pumps so less acidogenic
- Inhibits urease so bacteria less acidoduric
what is the critical pH in the mouth
-Solubility and therefore demineralization increases at low pH, below 5.5 (the critical pH).
- Calcium and phosphate are withdrawn from the enamel and into solution if pH is below this
How caries is caused
-bacteria metabolise free sugars in diet and produces lactic acid which demineralises minerals and disintegrates the organic material.
-Areas of the enamel can wear away creating a cavity.
-The bacteria and acid can reach the dentine which is softer and less resistant to acid. Dentine has tiny tubes that communicate with the pulp causing sensitivity.
- Bacteria can then make their way to the pulp which can become inflamed in response to the infection. The nerves become pressed, causing pain
-Primary teeth have thinner enamel & dentine so caries progresses more quickly.
-Posterior teeth have lots of grooves & multiple roots that collect food, and are harder to reach and clean so more prone to caries
What is IRMER and IRR. their aims, who they protect
-IRMER (2017)= ionising radiation medical exposure regulations. Protecting patients. Ensures good governance. Individuals are informed prior to exposure of the risks of any ionising radiation exposures they receive. Correct written protocols and documentation for procedures. Correct justification of exposures.
-IRR= Protecting staff and general public. Ensure staff follow local rules, code of practice, use warning lights, under close supervision.
Who sets the safe radiation doses
International Comission on Radiological Protection (ICRP)
What is a RPS and RPA
Radiation protection Advisor:
Is a medical professional that does routine checks, helps create local rules and helps with all aspects of radiation protection. checks the installation of radiation equipment
-Radiation protection supervisor:
- Is a named member of the practise who provide instructions to the radiology team and ensures local rules are followed
What are deterministic and non-deterministic effects of radiation
-deterministic= determined by dose. Effects include skin erythema (4Sv), cataracts, fatal death (50Sv)
-non-determinisitic= not determined by dose. No threshold dose value. occur by chance. There is no safe dose for even smallest amounts of radiation. no level of radiation where risk of cancer is zero
Different ways radiation can affect DNA, directly and indirectly
-Direct: Causes ionization which either can be repaired and survives, unable to repair causing cell death, mutate and cause cell death, or mutate and cause cancer where cell division does not stop
-Indirect: Interacts with water molecule causing it to split, causing free radical and causes unwanted reactions
Difference between absorbed dose, equivalent dose and effective dose of radiation. their units
-Absorbed= energy per unit mass of tissue (grey per m2 or DAP. How much hits the skin)
-Equivalent= considers radiation weighing. For X-rays you multiply by 1
-Effective dose (uSv)= more useful, considers type of tissue being radiated and how radiosensitive they are. Each tissue has specific values (eg. thyroid high so higher effective dose in mandible region)
How to calculate effective dose
equivalent dose x tissue weighting factor
=uSv