optional CIS

Question 1

leading cause of death of infants from 1 mo- 1 yr

Answer 1

SIDS

Question 2

is SIDS a legitimate cause of death

Answer 2

yes

Question 3

what is the most common finding in infants who died from SIDS

Answer 3

astrogliosis of the brainstem

Question 4

sudden death in a child <1 yr old with no signs of SIDS, genetic/congenital disease is typically due to

Answer 4

infection

Question 5

most common tumor of infancy

Answer 5

hemangioma

Question 6

reddish brown cystic lesion measuring 6.2 cm in sacrococcygeal region of 1 mo old
most likely Dx

Answer 6

benign cystic teratoma

not malignant because tend to happen >4 mo old

Question 7

4 y/o with thrombocytopenia and inc WBC
CBC with 20% blasts
most likely Dx?

Answer 7

B cell ALL

Question 8

wilms tumor and metastatic neuroblastoma don’t generate large WBC counts why?

Answer 8

neuroectoderm neoplasms

Question 9

20 mo old boy with distended abdomen, fever and weight loss
proptosis b/l
BP unremarkable
which of the following would be most useful in Dx?

Answer 9

because this is a neuroblastoma

serum catecholamines are most useful to Dx this

Question 10

what is a good prognostic factor for a 20 mo old with metastatic neuroblastoma

Answer 10

TRKA expression

Question 11

The 4S stage neuroblastoma is used for what age groups

Answer 11

only less than 1 yr old

Question 12

7 y/o with small abdominal mass, aniridia, genital anomalies and mentally challenged
PAX6 deletions and WTI assays exhibit mutations
most likely in this child?

Answer 12

Wilms tumor

Question 13

What are the 4 types of wilms tumors

Answer 13

sporadic
WAGR type
Denys Drash
Beck-wiedemann

Question 14

classically and primarily CF was considered to be a disease of the

Answer 14

lower respiratory tract

lungs

Question 15

what do most patients in the US with CF die from

Answer 15

cardiorespiratory disease

recurrent infections

Question 16

gonadoblastomas are most commonly assoc with

Answer 16

denys drash syndrome

Question 17

homicide on a death certificate means what

Answer 17

death was caused by other individual or entity

Question 18

42 y/o obese male heavy smoker
died
proximal atherosclerotic plaques in main coronary aa and concentric ventricular hypertrophy
most likely COD? mechanism?

Answer 18

COD: ASCVD
mech: cardiac arrhythmia

Question 19

if the brain tissue is extruded, lacerated and hemorrhagic than what does that tell you about the weapon

Answer 19

usually high velocity. not normally a handgun

Question 20

what is fixed livor mortis

Answer 20

has not been moved, been there a while

Question 21

how long does rigor mortis take

Answer 21

2-4 hours at room temp

Question 22

what does a green patch in the right lower quadrant of a dead person suggest

Answer 22

bacterial decomposition

Question 23

soot within the gun shot wound suggests what

Answer 23

close range, contact

Question 24

describe exits vs entry in high velocity weapons

Answer 24

exit>entry for high velocity

exit=entry for regular

Question 25

what type of gun is a revolver and semiautomatic

Answer 25

handguns

Question 26

do long barrels or short barrels have higher velocity

Answer 26

longer barrels- higher velocity

Question 27

what are smooth bore weapons

Answer 27

shot guns

Question 28

what is algor mortis

Answer 28

cooling of the body

Question 29

what is livor mortis

Answer 29

no more circulation
remaining vasculature sinks to the bottom
becomes fixed after 3-4 hours

Question 30

what is putrefactive decomp

Answer 30

bacteria reduce body to gas and water

Question 31

what is mummification decomp

Answer 31

very dry climates

body and soft tissue dehydrated

Question 32

what is adipocere formation

Answer 32

body in water for a long period of time
saponification
skin erodes

Question 33

what evidence cannot go in plastic bags? why?

Answer 33

biologic or organic

sun and water can degrade DNA