Option D Flashcards
What are nutrients?
Chemical substances in foods that are used in the (human) body
What are essential nutrients?
- Cannot be synthesised by the body
- Must be taken in by diet
What can be used for energy?
(In aerobic cell respiration)
- Carbohydrates
- Lipids
- Amino acids
(If energy in diet is insufficient)
- Glycogen + fat reserves
Measuring energy content (equation)
temp rise (c) x water volume (ml) x 4.2J
/ mass of food (g)
Measuring energy content (other)
Burning the food in a food calorimeter which traps heat from combustion (more efficiently)
What is there a correlation between for CHD?
High levels of cholesterol (in blood plasma) and an increased risk of CHD
Note: lowering cholesterol may not reduce risk of CHD
Vitamin D Deficiency (consequences)
- Not enough calcium is absorbed from food (in the gut)
- Same as calcium deficiency symptoms (eg. Osteomalacia)
What is osteomalacia and its consequences?
- Inadequate bone mineralisation (due to calcium salts not being deposited or reabsorbed)
- Bones become softened
Note: In children, it’s called rickets
How is vitamin D synthesised and stored?
- Contained in oily fish, eggs, milk, butter, cheese, and liver
- Can be synthesised in the skin (by UV light)
- Liver can store vitamin D in liver (for winter)
How is cholera caused?
- (Disease) Caused by infection of the gut w/ the bacterium ‘Vibrio cholerae)
- Releases toxin which binds to receptor on intestinal cells -> brought into cell (endocytosis)
- When in cell: triggers release of Cl- and HCO3- ions (from cell into intestine)
- Water leaves cell by osmosis (leads to watery diarrhoea)
- Water taken from blood into cells to replace the lost fluid (leads to dehydration)
Vitamin C deficiency (in mammals)
AKA ascorbic acid
- Needed for the synthesis of collagen fibres (in many body tissues + blood vessel walls)
- Scurvy = deficiency of vitamin C
- Essential nutrients for humans
How is stomach acid secreted?
Proton pump (H+/K+ ATPase) in parietal cells in stomach epithelium
- Pumps exchange protons from cytoplasm with potassium ions from the stomach
How is tyrosine synthesised?
Phenylalanine –(phenylalanine hydroxylase)—-> tyrosine
- Phenylalanine is an essential nutrient
What is phenylketonuria (PKU)?
Disease caused by too much phenylalanine in blood (due to lack of phenylalanine hydroxylase)
- Caused by mutation of gene coding for the enzyme
- Recessive allele
what are the consequences and treatment of PKU?
- Diet with low levels of phenylalanine (Eat small amounts of meat, fish, nuts, cheese, and beans) AND (maybe) tyrosine supplements
- Causes reduction in head + brain growth in newborns
What causes stomach ulcers?
Partial digestion of the stomach lining by the enzyme pepsin + hydrochloric acid (in gastric juice)
How are digestive juices secreted?
Exocrine gland: secrete through duct onto surface of the body or into the lumen of the gut
Endocrine gland: ductless, sectete hormones directly into the blood
- Only exocrine glands secrete digestive juices
What does gastric juice do?
- Secreted by cells in epithelium that lines the stomach
- Hydrogen ions are secreted by the parietal cells -> makes contents of stomach acidic
- Helps w/pathogen control + assist w/some hydrolysis reactions
How is the secretion of gastric juice controlled?
- By nerves AND hormones
Nervous mechanism:
1. Sight + smell of food triggers response by which gastric juice is secreted by the stomach
2. When food enters stomach -> distension (detected by stretch receptors)
3. Signals sent to brain to release digestive hormones
Hormonal mechanism:
1. Gastrin is secreted into bloodstream + stimulates release of stomach acids
2. If stomach pH is too low (becomes acidic) gastrin secretion is inhibited
3. When digested food passes into small intestine, digestive hormones are released
What are the functions of the liver?
Detoxification: hepatocytes absorb toxic substances from blood + convert them by chemical reactions into non-toxic or less toxic substances
Breakdown of erythrocytes: kupffer cells in the walls of sinusoids absorb + break down damaged red blood cells + recycle them
Cholesterol to bile salts: converted by hepatocytes
Production of plasma proteins: rough ER (of hepatocytes) produce 90% of proteins in blood plasma
Nutrient storage + regulation
How does blood flow through the liver?
Hepatic portal vein = deoxygenated (already flowed through stomach/intestine walls)
Hepatic portal vein - divides into sinusoids
Hepatic artery = oxygenated blood (from aorta)
Hepatic artery - branches into capillaries (join sinusoids)
What are the features/structures of sinusoids?
- Wider than normal capillaries
- Wall = single layer of thin cells
- Pores + gaps between cells = allow blood flow in sinusoids to be in close contact to hepatocytes
What is juandice?
- Skin and eyes become yellow
- Caused by accumulation of bilirubin in blood plasma
- Caused by things such as hepatitis, liver cancer, and gallstones
- In infants: can cause brain damge that leads to deafness + cerebralpalsy
-In adults: itchiness
What is the role of lipoproteins?
- Transports cholesterol
- Low density lipoproteins (LDL) = bad – carries cholesterol from liver to body tissue
- High density lipproteins (HDL) = good – collects cholesterol from body tissue + takes to liver for removal from the blood