Optimizing Obesity Treatment Using Medication Combinations

Question 1

Where does topiramate act on the brain?

Answer 1

GABAergic receptors

Question 2

What parts of the brain do Naltrexone interact with

Answer 2

POMC/CART

Question 3

What parts of the brain do bupropion interact with

Answer 3

VTA

Question 4

What parts of the brain do phentermine interact with

Answer 4

VTA

Question 5

What parts of the brain do liraglutide interact with

Answer 5

POMC/CART

Question 6

Choice of obesity medications for binge eating

Answer 6

lisdexamphetamine

phentermine/topiramate (qysmia)

Question 7

Choice of obesity medications for depression

Answer 7

bupropion

naltrexone/bupropion

Question 8

Choice of obesity medications for anxiety

Answer 8

topiramate

Question 9

Choice of obesity medications for “sugar addiction”

Answer 9

naltrexone

topiramate (soda)

naltrexone/bupropion

phentermine/topiramate

Question 10

Choice of obesity medications for “fat addiction”

Answer 10

naltrexone/bupropion

orlistate

Question 11

Choice of obesity medications for ADHD

Answer 11

bupropion

lisdexamphetamine

Question 12

Choice of obesity medications for volume eater

Answer 12

liraglutide

Question 13

Choice of obesity medications for compulsive behaviors

Answer 13

bupropion

Question 14

Choice of obesity medications for low metabolic rate

Answer 14

phentermine

phentermine/topiramate

Question 15

Which two medication combinations should i never use

Answer 15

contrave and qsymia

Question 16

Reasons to choose phentermine

Answer 16

inexpensive, time tested

Question 17

Reasons to not choose phentermine

Answer 17

stimulant side effects - anxiety, irritability

schedule 4 controlled substance

known cardiac dz

Question 18

reasons to choose topiramate

Answer 18

double benefits for migraines, sz, binge eating, bipolar

may help insomnia, reduce soda intake excessive carb intake

inexpensive

Question 19

reasons to NOT choose topomax

Answer 19

cognitive, word finding difficulty

teratogenic effect (planning to be preggers)

Question 20

reasons to choose qsymia

Answer 20

double benfits for migraines, sz, binge eating, bipolar

may help insomnia, reduce soda intake, escessive carb intake

highly effective

Question 21

reasons to NOT choose qsymia

Answer 21

stimulant effect

teratogenic effect

expensive

hx of kidney stones or glaucoma

Question 22

reasons to choose saxenda

Answer 22

double benefits for DM

Improves HTN, cardiovascular risk

lack of central effects

highly effective

Question 23

reasons to NOT choose saxenda

Answer 23

gastroparesis

history MTC

history of pancreatitis

expensive

Question 24

reasons to choose contrave

Answer 24

double benefits ETOH and smoking cessation

helps iwth depression

DM improvement

helps with excessive cravings, hedonistic food drive

Question 25

reasons to NOT choose contrave

Answer 25

stimulant side effects nausea (naltrexone) expensive hx of sz uncontrolled HTN active bullemia less effective

Question 26

reasons to choose orlistate

Answer 26

hyperTG no central side effects

Question 27

reasons to NOT choose orlistat

Answer 27

less effective GI side effect profile B12 deficiency

Question 28

reasons to choose metformin

Answer 28

double benefit for PCOS, DM, atypical antipsych meds can be used in pregnancy inexpensive

Question 29

reasons to NOT choose metformin

Answer 29

GI side effect profile B12 deficiency