Optic atrophy

Question 1

Optic atrophy on fundoscopy

Answer 1

pale, well demarcated disc

sually bilateral and causes a gradual loss of visio

Question 2

acquired cause of optic atrophy ?

Answer 2

multiple sclerosis

papilloedema (longstanding)

raised intraocular pressure (e.g. glaucoma, tumour)

retinal damage (e.g. choroiditis, retinitis pigmentosa)

ischaemia

toxins: tobacco amblyopia, quinine, methanol, arsenic, lead

nutritional: vitamin B1, B2, B6 and B12 deficiency

Question 3

Congenital causes of optic atrophy ?

Answer 3

Friedreich’s ataxia

mitochondrial disorders e.g. Leber’s optic atrophy

DIDMOAD - the association of cranial Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness (also known as Wolfram’s syndrome)